Protein
Tetratricopeptide repeat-containing protein trd-1
Organism
Caenorhabditis elegans
Function
Developmental protein required for cell fate determination in both the germline and seam cells of the developing epidermis. Specifically, involved in sex determination and may function in parallel or downstream of other sex determination factors, including tra-2 and fem-3, to promote oogenesis in its role in the regulation of the switch from spermatogenesis to oogenesis in the gonads. Also implicated in the mitosis to meiosis switch in distal tip cells.
Similarity
Belongs to the TTC27 family.
Sequence
MIPADIIASIAGLVNEKDIEKITSEYQDNIWEFVESLVTHVLASNHVGYSDYNTSSFISEELARQKLSCGLNIPNAVSKSLWALHLAHEHVEKLKDLSDIPPIGYRVILEFYLVWQQLLIDPEETIRTEIEPIMEKLRVLIAEENDAFTSEDRCQIQLEMAAVRFQFYEYDKADNLIKSASEECQLNMDLSGMMGKRTRFQQRDIAQLVLIHKDPSTTGTPLPPDSDIPQSLDMNDDTLLEQVAITEQGARVDGRTLNACQLSCLLWIARHESATHRHDVLVHERCSPVLDTVIAARRYWSIQAAALLARAELERGRVRQVDRSCTQSELVVKLQQGVDDPVLIKDRLLRTSYILASGLTPFWQSSVLLAGILNSLGCTSEALLILEKLEMWDGVIDCYKQLGQMDKAETLIRRLIEQKPNDSMLHVYLGDITRNLEYFTKAIELSDDRNARAHRSLGHLLLMDKKFEEAYKHLRRSLELQPIQLGTWFNAGYCAWKLENFKESTQCYHRCVSLQPDHFEAWNNLSAAYIRHGQKPKAWKLLQEALKYNYEHPNVWENYMLLSVDVGEFSQAIQAYHRLLDMNKRGADDEVLELIAQTLLRREAEISMDESEDKAQNEAENRKEKEEMIKLLARISANHQTLSPKTLRVYALLKKPSVLSSETRTEFEKYVRLLEKSLAAANGKLTWPKEEKLALEVVETAVRLAEDRLELAKFIASDTSVKEASAKVRLSLRGILTRLDKDSGSRVSGDETEKLQEIVEVAKSLLDSVAI