Function
Plays a major role in controlling sexual phenotype (PubMed:18245372). Terminal global regulator in a well-characterized cascade of sex-determining genes (By similarity). Promotes female development (By similarity). Interacts with tra-2 to promote spermatogenesis (PubMed:11250902). Promotes spermatogenesis through the Tip60 HAT complex and by regulating the expression of genes, such as fog-3, required for male development (PubMed:24098152). Association with chromatin and at the fog-3 promoter requires wdr-5.1, and may also require wdr-5.2 (By similarity). With trr-1, activates the fog-3 gene to determine sperm/oocyte cell fate (PubMed:24098152). In hermaphrodites, binds to an intronic regulatory site in the ceh-30 gene, preventing ceh-30 transcription and thereby preventing survival of the CEM (cephalic male) sensory neurons (By similarity).
Sequence
MMAPSTEDPETVVEAQRRGSFSKKNGNGWTKPGLANGSESKHMEPVTGTNALMAAIDADDQETKLKDPLEKEASTYKSATDRFFQSSHPPSHQTVENPIKLEPPTSSGVTQNGSPVTNSLVPEAAQPLQTVAESSEPTAASAEPTDASSAESSTITVTPVVPVVKFTNQTTPNGSTVATSVGQNVRLTINGKRVGRPPGTFKRPPNNPTTNTSHGEETDSEASTDLICRWKDCMLKFANLKGLVEHVQEKHVQSTEQEHHAWRCEWEGCDRNETFKALYMLIVHVRRHTGEKPNKCEYPGCGKEYSRLENLKTHRRTHTGEKPYKCEFSDCEKAFSNASDRAKHQNRTHSNLKPYSCQIGGCQKSYTDPSSLRKHIKAVHGDEEYEKAKKSRPPNYSNRRRPDHRMPPPTSAMSHPYLAPPHVLPPVAAPGVHQQNFINLALAQHHHNQRAQFIANNAALMDPNGSGAAQAAAAAQAAQAQQAQMYQAQAMQQHQFAAQMQQQAVMQVHMQQAALQQAQVAIIQNNLLSTQGIMNQFPMMSPLLTPRAPGNVMSLLQQQQVTPPTPTMMQLTPHTPITPITPITPLTPMGATTGPMFSMPNIMMTTPVRMDIPTSVPAAVPVAPVAPVAPVAPAAPVAPPASSLAEATEPRFRLLRQHMEGAEVAPVLAPQQPLEEDDDMTDDEESGNVAPAVIRNGDGPDDRNSGTGSSSPRSSASSGSGTLEVAGSVAQNGNRSSSTGERGMRSFLIADILQMAHDFQNGRIITDALHKAIFDTSDVTAMFHIYRTFECVCEYLQFTFSAGERLPTWPEVRTIHEYYHSDYDRTRFHASETVRRRDNLFWRFVNYCNSDLPIGGRPILSVSYDEGFEESIDQGSNFGTIPQQLISRMAAEAFDDEDDGFDDAFDIPGLRLGGVEVLIQQQRHRVRRAALKQAQIDYPTAEEDLGYVGGGFGQEDDDHHSYAIYEQQKTVAFVDLSEKPKVEVLTDEDFMEQFKAAEARCQARLAIEPMVKVARTVINGKVVEYTESQLFSPPVSRRTIYSMLKQFPEHQENLLKFITLHVDKCELENVIPSREYMSDMESSFFAHHRIVRAALRARGEITEAEEAEYQQSSNLMYNQDFAALMFPELDESHDDFLNDLPISSRRRSSDSDSKEAPSMKKPRSF