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tra-1

Gene
tra-1
Protein
Sex-determining transformer protein 1
Organism
Caenorhabditis briggsae
Length
1165 amino acids
Function
Plays a major role in controlling sexual phenotype (PubMed:18245372). Terminal global regulator in a well-characterized cascade of sex-determining genes (By similarity). Promotes female development (By similarity). Interacts with tra-2 to promote spermatogenesis (PubMed:11250902). Promotes spermatogenesis through the Tip60 HAT complex and by regulating the expression of genes, such as fog-3, required for male development (PubMed:24098152). Association with chromatin and at the fog-3 promoter requires wdr-5.1, and may also require wdr-5.2 (By similarity). With trr-1, activates the fog-3 gene to determine sperm/oocyte cell fate (PubMed:24098152). In hermaphrodites, binds to an intronic regulatory site in the ceh-30 gene, preventing ceh-30 transcription and thereby preventing survival of the CEM (cephalic male) sensory neurons (By similarity).
Similarity
Belongs to the GLI C2H2-type zinc-finger protein family.
Mass
128.954 kDa
Sequence
MMAPSTEDPETVVEAQRRGSFSKKNGNGWTKPGLANGSESKHMEPVTGTNALMAAIDADDQETKLKDPLEKEASTYKSATDRFFQSSHPPSHQTVENPIKLEPPTSSGVTQNGSPVTNSLVPEAAQPLQTVAESSEPTAASAEPTDASSAESSTITVTPVVPVVKFTNQTTPNGSTVATSVGQNVRLTINGKRVGRPPGTFKRPPNNPTTNTSHGEETDSEASTDLICRWKDCMLKFANLKGLVEHVQEKHVQSTEQEHHAWRCEWEGCDRNETFKALYMLIVHVRRHTGEKPNKCEYPGCGKEYSRLENLKTHRRTHTGEKPYKCEFSDCEKAFSNASDRAKHQNRTHSNLKPYSCQIGGCQKSYTDPSSLRKHIKAVHGDEEYEKAKKSRPPNYSNRRRPDHRMPPPTSAMSHPYLAPPHVLPPVAAPGVHQQNFINLALAQHHHNQRAQFIANNAALMDPNGSGAAQAAAAAQAAQAQQAQMYQAQAMQQHQFAAQMQQQAVMQVHMQQAALQQAQVAIIQNNLLSTQGIMNQFPMMSPLLTPRAPGNVMSLLQQQQVTPPTPTMMQLTPHTPITPITPITPLTPMGATTGPMFSMPNIMMTTPVRMDIPTSVPAAVPVAPVAPVAPVAPAAPVAPPASSLAEATEPRFRLLRQHMEGAEVAPVLAPQQPLEEDDDMTDDEESGNVAPAVIRNGDGPDDRNSGTGSSSPRSSASSGSGTLEVAGSVAQNGNRSSSTGERGMRSFLIADILQMAHDFQNGRIITDALHKAIFDTSDVTAMFHIYRTFECVCEYLQFTFSAGERLPTWPEVRTIHEYYHSDYDRTRFHASETVRRRDNLFWRFVNYCNSDLPIGGRPILSVSYDEGFEESIDQGSNFGTIPQQLISRMAAEAFDDEDDGFDDAFDIPGLRLGGVEVLIQQQRHRVRRAALKQAQIDYPTAEEDLGYVGGGFGQEDDDHHSYAIYEQQKTVAFVDLSEKPKVEVLTDEDFMEQFKAAEARCQARLAIEPMVKVARTVINGKVVEYTESQLFSPPVSRRTIYSMLKQFPEHQENLLKFITLHVDKCELENVIPSREYMSDMESSFFAHHRIVRAALRARGEITEAEEAEYQQSSNLMYNQDFAALMFPELDESHDDFLNDLPISSRRRSSDSDSKEAPSMKKPRSF

Gene
tra-1
Protein
Sex-determining transformer protein 1
Organism
Caenorhabditis elegans
Length
1110 amino acids
Function
Plays a major role in controlling sexual phenotype (PubMed:1339311). Terminal global regulator in a well-characterized cascade of sex-determining genes (PubMed:8367286). Promotes female development (PubMed:11124807). Interacts with tra-2 to promote spermatogenesis (PubMed:11250902). Promotes spermatogenesis through the Tip60 HAT complex and by regulating the expression of genes, such as fog-3, required for male development (By similarity). Association with chromatin and at the fog-3 promoter requires wdr-5.1, and may also require wdr-5.2 (PubMed:24682813). With trr-1, activates the fog-3 gene to determine sperm/oocyte cell fate (By similarity). In hermaphrodites, binds to an intronic regulatory site in the ceh-30 gene, preventing ceh-30 transcription and thereby preventing survival of the CEM (cephalic male) sensory neurons (PubMed:18056428).
Similarity
Belongs to the GLI C2H2-type zinc-finger protein family.
Mass
122.804 kDa
Sequence
MMAPSTEDPDTVVEAQRRGSFSKKKNANGWNKVELVDQCAKQMGSEDKQPGGGDVKTENDPSKNGLGSATSNFIQSSVPPSHQTLSNPLQLSPPAEASVAQQSGASQVFPTFQAALGASSDELLQPNATSSSTSSSASTSSIVPVVKFTNQTAPNGSTVATSVGQNVRLTINGKRVGRPPGTFKRPQNNAANSSNSGNDSDMMGDHDLTCRWKSCNSSFQTLKALVDHVQESHVQSTEQEHHAWRCEWEGCDRNETFKALYMLIVHVRRHTGEKPNKCEYPGCGKEYSRLENLKTHRRTHTGEKPYKCEFADCEKAFSNASDRAKHQNRTHSNLKPYSCQIPQCTKSYTDPSSLRKHIKAVHGDDEYEKAKKSRPANYSNRRRPDHRLAPPTGAMSHPYLATPNSGASVVAHSSVHQQNFINMALAQHHHNAQRAQQLMAATGNVMPMMDPASAAAAAQAQAHHQAQAQMLQTHMMQQAQIQAAAQMQAQVQHQAAMQAHAMQQAQMVLQNNLLGAQSLLSPFSPLLPPSRAPNVMAMLQTPPTPTSVAPMFDIMTSRAPMAPVVSAPTAPAPLVPAPVPASPVFDELREQMREVEPLQQQQQQEPMDQDLQDIRVDGDSDDEDEEEPRTPSGALLLPRGGNNGDGGFGGSGSSRASSGSGTMELSAAPISQNGSRASGSGERGMRSFLIADILQLAADFQNERLLSDVLDLAIFDTRDVRSLHNIYQVYIRAHKAIPITRRPLDWNETHQLHNLYHDPRFNRAEHQDSPAIRDRDTRFWRTIAEANTMRQRQIEPVPLDDDDEGYFDEMVHRVQNGRLNEQFMEGFESDDDDGFEDEDDVPGLGIAVYRGRRRVRREALKQANLDIQEAETAGRNVGGFGDEEDRNNRGHDQDRSFLDHYYPPMVVVVETESPQIVRDQEMMRQFEEAKKNVETDEIKKRAEAMQFGTSSSHHHTKTLLIQRALFDKTSSVRRSLLQFITISVDQEELRQSCHATSAPQGAHVVHNVVDEFDSIMRAQEDSNNRILLSLDIPAPSAVTGVSGSITHADNSALQLQQEQPTSSFSSWFPEDDPIYALPPPPPPPAPPRRRRSADNKDDSENIPKKPRHQF