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tollip-b

Gene
tollip-b
Protein
Toll-interacting protein B
Organism
Xenopus laevis
Length
269 amino acids
Function
Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance.
Similarity
Belongs to the tollip family.
Mass
29.983 kDa
Sequence
MATSISTQRGQVFIGELPQDFLRISPTQQQQQIQLDAQAAQQLQYSGVMATMGRLSITVVQAKLAKNYGMTRMDPYCRIRLGYAVYETPTAHNGAKNPRWNKVIQCTIPPGVDSFYIEIFDERAFSMDDRIAWTHITIPETLKEGKHVDEWFSLSGKQGDDKEGMINLVMSYTSVPAMMPAQPVVLMPTVYQQGVGYVPIADPIYNPGMPMAAPPPAVNPQHETREEDIQSIKDMFPTMDPEVIRSVLEAQGGNRDAAVNSLLQMVEDS