Protein
Telomere length and silencing protein 1
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Function
Involved in the regulation of heterochromatin assembly at telomeric regions. Involved in the control of telomere length. Regulates spliceosome assembly by associating with brr2. Regulates the proper splicing of mRNAs of the shelterin components rap1 and poz1 to control telomeric heterochromatin assembly and telomere length.
Similarity
Belongs to the TLS1 family.
Sequence
MNSIHIKKKSNRSFRRRKVFGNEKEFDLEELDDNDIRLRQALEATKRRKIRNSIIGINAEKLLNQETKKEKQLNTANEPHEANDQTSAQSSKLIEAQLPTVEDRFAKQTNEVDINTHLLNFVEKKLKQERLAQNYSENGETNALNTKNESTVQNIKNSLHPNEHSFIRDAAALGAIREVDLGIISTDVDNLKNGRKRQKKRARMKEKLDSKALRTSEDAARDEFIEKMLKPISQDEESKGIYRRFRVYKDGTQD