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tim

Gene
tim
Protein
Protein timeless
Organism
Drosophila melanogaster
Length
1398 amino acids
Function
Required for the production of circadian rhythms. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition.
Similarity
Belongs to the timeless family.
Mass
156.382 kDa
Sequence
MDWLLATPQLYSAFSSLGCLEGDTYVVNPNALAILEEINYKLTYEDQTLRTFRRAIGFGQNVRSDLIPLLENAKDDAVLESVIRILVNLTVPVECLFSVDVMYRTDVGRHTIFELNKLLYTSKEAFTEARSTKSVVEYMKHILESDPKLSPHKCDQINNCLLLLRNILHIPETHAHCVMPMMQSMPHGISMQNTILWNLFIQSIDKLLLYLMTCPQRAFWGVTMVQLIALIYKDQHVSTLQKLLSLWFEASLSESSEDNESNTSPPKQGSGDSSPMLTSDPTSDSSDNGSNGRGMGGGMREGTAATLQEVSRKGQEYQNAMARVPADKPDGSEEASDMTGNDSEQPGSPEQSQPAGESMDDGDYEDQRHRQLNEHGEEDEDEDEVEEEEYLQLGPASEPLNLTQQPADKVNNTTNPTSSAPQGCLGNEPFKPPPPLPVRASTSAHAQMQKFNESSYASHVSAVKLGQKSPHAGQLQLTKGKCCPQKRECPSSQSELSDCGYGTQVENQESISTSSNDDDGPQGKPQHQKPPCNTKPRNKPRTIMSPMDKKELRRKKLVKRSKSSLINMKGLVQHTPTDDDISNLLKEFTVDFLLKGYSYLVEELHMQLLSNAKVPIDTSHFFWLVTYFLKFAAQLELDMEHIDTILTYDVLSYLTYEGVSLCEQLELNARQEGSDLKPYLRRMHLVVTAIREFLQAIDTYNKVTHLNEDDKAHLRQLQLQISEMSDLRCLFVLLLRRFNPSIHSKQYLQDLVVTNHILLLILDSSAKLGGCQTIRLSEHITQFATLEVMHYYGILLEDFNNNGEFVNDCIFTMMHHIGGDLGQIGVLFQPIILKTYSRIWEADYELCDDWSDLIEYVIHKFMNTPPKSPLTIPTTSLTEMTKEHNQEHTVCSWSQEEMDTLYWYYVQSKKNNDIVGKIVKLFSNNGNKLKTRISIIQQLLQQDIITLLEYDDLMKFEDAEYQRTLLTTPTSATTESGIEIKECAYGKPSDDVQILLDLIIKENKAQHLLWLQRILIECCFVKLTLRSGLKVPEGDHIMEPVAYHCICKQKSIPVVQWNNEQSTTMLYQPFVLLLHKLGIQLPADAGSIFARIPDYWTPETMYGLAKKLGPLDKLNLKFDASELEDATASSPSRYHHTGPRNSLSSVSSLDVDLGDTEELALIPEVDAAVEKAHAMASTPSPSEIFAVPKTKHCNSIIRYTPDPTPPVPNWLQLVMRSKCNHRTGPSGDPSDCIGSSSTTVDDEGFGKSISAATSQAASTSMSTVNPTTTLSLNMLNTFMGSHNENSSSSGCGGTVSSLSMVALMSTGAAGGGGNTSGLEMDVDASMKSSFERLEVNGSHFSRANNLDQEYSAMVASVYEKEKELNSDNVSLASDLTRMYVSDEDDRLERTEIRVPHYH

Gene
tim
Protein
Protein timeless
Organism
Drosophila virilis
Length
1343 amino acids
Function
Required for the production of circadian rhythms. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition (By similarity).
Similarity
Belongs to the timeless family.
Mass
150.944 kDa
Sequence
MDWLLATPQLQSVFSSLGSLVGGTYVVSPNALAILEEINHKLTYEDQTLRTFRRAIGFGQNVRVDLIPLLENAKDDAVLESVIRILVNLTVPVECLFSVDLMYRTEVGRHTIFELNKLLYNSKEAFTDPKSTKSVVEYMKHILESDPKLSPHKCDQINNCLLLLRNILHIPETHAHFLMPRLQPGSGHQVSMQNTILWNLFIQSIDKLLLYLMTCPQRSLWGVTMVQLIALIYKDQHVSTLQKLLNLWFEASLSESSDDNESNTTPPKQASGDSSPMLTSDPTSDSSDNGSGGKKESCEERRQALREGTDATLHEVSRKGHEYQNAMASSNAANYILEGPCSAQQPWSDCEMQEYKQMTAVISEPLNLSQPADNVNYTTNANYARTTSTDILTKTTSLKHEGFKPPAPRRNTLSAILSDNYAPLSFISAVKLGQKSPHAGQLQLIKGKCCPQKRECPSSQSEHSDCGYGTQMENPESISTSSNDDDGPQGKPQHQKPPCSSKHRSKQRIFAVPQDTKDLRRKKLVKRSKSSLINMKGLVLHTPNDDDISNLLKEFTVDFLLKGYNYLVEELHSQLLSNAKMPIDTSHFFWLVTFFLKFAAQLELDMEHIDTILTFDVLSFLTYEGVSLCEQLELNARQEGADLRPYLRRMHLVVTAIREFLQAIEAYNKVTHLSEDDRYRLRQLQLQISATTDLRCLFVLLLRRFNPSIHSKQYLQDLVVTNHILLLILDNAAKLEGGQTIGLSEHISQFATLEVMHYYGILLEDFSNNGEYVNDCIFTMMHHIGGDLDQVGVLYQPIILKAYSRIWEADYDICDDWSDLIEYVIHKFLNTPPKSPMAIPTASLTELTKEQNQEHTACPWSQEDMDSLCWYFVQSKRQNDVIGNIAKLFSNNGNKIKTRISIIQQLLQQDIITLLEYDDLMKFEDAEYQRTLLATPTSLTTDSGIELKESAYGKPSDDVQVLLDLIRKENKSQHLVWLQKLLLECCYVKMMIKCGSCQTDVEPIMEPVVYHCMFKQKPIPVVQWNNEQSSTMLYQPFMLLLHKLGIQLPADAGLIFARIPDFWTPETMYGLAKKLGPLDKLTLKFDPRDLEDAPPSRHHTGARNSLSSISSLEADFGDSEGLALIPEVDPAVEKAAAAASAIPNNEIFALPRVKHCNSIIRYTPDPTPPVPSWLQLVMRTKCSKRRSPATDASDCTSTSTMIADDEIKSYASMAQASHTKLNSGYPTSTLVCMNKLSNCSFAAPPNENSSSSGCGGTASSMSMPNMPDGNSDALMKTSFERLAVTGARYLRPSNTDQDYSALVASVYENEFANSDNVSVASDLTRMYVSDEDEKHELQLQQVE

Gene
tim
Protein
Protein timeless
Organism
Drosophila hydei
Length
676 amino acids
Function
Required for the production of circadian rhythms. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition (By similarity).
Similarity
Belongs to the timeless family.
Mass
76.023 kDa
Fragment
single
Sequence
MLLRNILHIPETHAHFLMPVLQSSGGHQVSMQNTILWNLFIQSIDKLLLYLMTCPQRALWGVTMVQLIAMIYKDQHVNTLQKLLNLWFEASLSESSEDNESNTSPPKKGSGDSSPMLTSDPTSDSSDNGSNGGGSSGKKEGCDERRQALREGTEATLQEVSRKGHDYQNAMARVTADKPDISEVASDSFEVPCSPQQHLNTEEAMDDIDYEEQVQEYEQEAAAVSSEPLNLSQPANNVNYTTNAVYASTTATETQTTSSLCAMTSLCYEPFKPPAPLPTRRNTLSEMLSDNYTSHSHVSAVKLGQKSSHAGQLQLTKGKCCPQKRECPSSQSELSDCGYATQVENPESISTSSNDDDGPQGKPQHQKPPCNTKPRNKQRTLMSPQDKKELRRKKLVKRSKSSLINMKGLVQHTPTNYDISNLLKEFTVDFLLKGYNYLVEELLKQLLTSAKVLIDTSHFFWLVTFFLKLAAQLELDMEHIDSILTYDVLSYLTYEGVSLCEQLELNAQQEGSDLQPYLRRMHLVVTAIREFLQTIETYNKVSHLSEDDRLRLHQLQLQIGATTDLRCLFVLLLRRFNPRIHSKQYLQDLVVTNHILMLILDSAAKLEGGQTIGLSEHISQFATLEVMHYYGILLEDFDNNGEFVNDCIFTMMHHIGGDLGQIGVLFQPIILKTYSR

Gene
TIM
Protein
Triosephosphate isomerase, chloroplastic
Organism
Arabidopsis thaliana
Length
315 amino acids
Similarity
Belongs to the triosephosphate isomerase family.
Mass
33.346 kDa
Sequence
MAATSLTAPPSFSGLRRISPKLDAAAVSSHQSFFHRVNSSTRLVSSSSSSHRSPRGVVAMAGSGKFFVGGNWKCNGTKDSIAKLISDLNSATLEADVDVVVSPPFVYIDQVKSSLTDRIDISGQNSWVGKGGAFTGEISVEQLKDLGCKWVILGHSERRHVIGEKDEFIGKKAAYALSEGLGVIACIGEKLEEREAGKTFDVCFAQLKAFADAVPSWDNIVVAYEPVWAIGTGKVASPQQAQEVHVAVRGWLKKNVSEEVASKTRIIYGGSVNGGNSAELAKEEDIDGFLVGGASLKGPEFATIVNSVTSKKVAA