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tilS1

Gene
tilS1
Protein
tRNA(Ile)-lysidine synthase
Organism
Neisseria meningitidis serogroup B (strain MC58)
Length
426 amino acids
Function
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
Similarity
Belongs to the tRNA(Ile)-lysidine synthase family.
Mass
47.732 kDa
Sequence
MKDCFPQGLNGKKTAVALSGGLDSVVLLHLLVRAGKKGGFIPDALHIHHGLSPRADDWADFCQNYCDMLGVGLETVKVCVEKNGLGIEAAARQKRYAAFAEKGFDVLALAHHRDDQIETFMLAVARGGGLRALAAMPAVRPFGEKGIIWRPLLPFSRQDIWDYAQKHGLPNIEDESNTDTAYLRNRFRHRILPELSAQIPHFGRHVLNNVRALQEDLALLDEVVVQDCRWVCGAGYFDTARWLTFSPRRKTHILRHFLKENGIPVPNQNALADIARVLTEAKTGRWNLQGFELHHYAGRLFVFRLEKTDKLRFLKDRQISGNLREILTGQGFVLKRHPFGLPEHLLEQDGILRTVAASDTLAMGGIHKDVKKILQGKRVLPVLRPIWPLVADSGNRPLALANCCADFQYSVSDGILPVHPDFPILF