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tigara

Gene
tigara
Protein
Probable fructose-2,6-bisphosphatase TIGAR A
Organism
Danio rerio
Length
256 amino acids
Function
Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate. Acts as a negative regulator of glycolysis by lowering intracellular levels of fructose-2,6-bisphosphate in a p53/TP53-dependent manner, resulting in the pentose phosphate pathway (PPP) activation and NADPH production. Contributes to the generation of reduced glutathione to cause a decrease in intracellular reactive oxygen species (ROS) content, correlating with its ability to protect cells from oxidative or metabolic stress-induced cell death. May play a role in mitophagy inhibition.
Similarity
Belongs to the phosphoglycerate mutase family.
Mass
28.18 kDa
Sequence
MLAFGLTVVRHGETQCNKDGLLQGQKIDSLLSDIGIQQSEAAGQYLRDVKFTNVFVSNMKRAKQTAEIIVRNNRTCHDLELVADPSLIERSFGIAEGGRVIDMKNMAKAAGQPLPEFTPPEGETMEQVKLRIKDFLKAMYQRIANDHQDKVQDGGTSSADESTEAPAGLANDGVSSVPVHALVVGHGAYMSIAMRYFFEDLKCPVPRGLDPAQQFSICPNTGMCRFIITLKCSSVDIALSDIKCVFINRRDHFKTN