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ticrr

Gene
ticrr
Protein
Treslin
Organism
Xenopus laevis
Length
1985 amino acids
Function
Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with topbp1 by participating in cdk2-mediated loading of cdc45l onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation.
Similarity
Belongs to the treslin family.
Mass
221.396 kDa
Sequence
MAPSHNVVLLVDTAESSDKSRLRRVSLRLLNFLACRAGLGQVRWSYRFLNSSGGRCRPPRRSDLRELGPRGWEEFEDELEACWERARNCRPSSTQSSRAQLLQTALMETLADFQWDRPDITSPTKPTLLRSRRGRIVAADEPLKDDSPDNFINPHSRNSIFLLSSCPHSGTELGQFAATSGDFSTQKVMDKLLPKSLQKIVSSKRVRVYWLDTSDWTQFGSSSDHSGYWTMVELMHQVEGRILPSESILGSSCQKAKTLPSFSVPPINIPFESVLNYLIFSEPDYQLWFPRRDGILFLTGKDGTKQLDCAVSLEPVSMIQKLSTSLMTIELKGTMQNCNLPLAGLRVETWLLHNSDCVQLQKLTKELMLKELHMIATVTLEDDVLPRTGILSPLSETAAVLNVICSERTLGLDNLHVQGSVHETDKETFSDLPDIVMSVLNHVYSSEDNTLAPDFPVPEWIKQELSQSSRWTSSVTARWYPLSGVSGASCNLMESFRLINAASSNCDEHLKFDQELTNYLSEFYQKKSVDDAGLGVHRENQKKSGLPRTPVRQKMKTLPRALQMLNAARLNVKAQKADSTLPVPNEKNSQMKRRSSGKQDNKPKQLKPTEFQSEDGLISYIKENYEEAVSLVDHSTMTWARDTLTTIKSYLKSIGSEQIETEAIDKVKLLFKTSKVIRQNYRNNQDKEVKLKECQLQVFLRLEMFVQCPVIQMDSDELELIIEEITDILRIVSLTEDPLFLTKFLEVDVLTQYIASVPKILADIYFSLGTQIPEVLVLVLPSDGDDSIMHEEKSVKSQPSTSRVPSVAPIGAETDQLEDLRTRSAKKRRSTALARHRSVAESSQSFRQIEVPKRQPNKENVQSNAVVVLEKLKLPLPAQPQKDAEAKVRRNLFIQETRSPSKRCSKMPRSQSVSAVESLKRKRSKSHDGSKDHHKLLTKKVSETPVHKQTANRLLLRQIKGRPSESNSNISIVEESPEKEIRDIDLRRSPRIKQLSLTRRNSSSFYASQPKSRNLERVNSATQLQQSRERPGSCLISEVKTPKRLLFGEVLGMISPPTTKRSRRILDMVNPVYKTPGKTPRKTPSKNIPNFEDQSGNMLVKSPCTPYTPRTPSRTPKRLKTPSKGSTERKKAAKNLGKLFSPSKPEEKSPLKLWGRRSERLAQMTPGKDGSPYKQSVCQTLMEVKTPQKLQRLESKDFRTPSRTPTRSNNTTPAKQSMQISNTPRKSDLKHPQEHESRGPSGYILWTPQKRILASVPHTPILQTPQKPISASVPRTPVCRTPQKAILSSVPSTPVCQTPNKAILTSVSRTPVYQTPQKAILASVMSTPVYQTPQKPVLASVPTTPILKTPQRSALASVSHTPSPKKYIMKELTVAITRMRECTPEKVLGSNLSSSATPSSALKSFCSEKTTSVCQTPKKSSIALLKPCDSLEFSGAPERLMDSLCSNKDSTKAETACTVPSQISTQMQNVINAGECTDSLSQTSVSSPSIPFTDKSLSPDLKDALSDVTSSKAEGVTIVSEKLDSSSMDSQEATDSFINSSQTEESIDISEARVVSTEASELKMKVLITRKPSGSGVSYLPTTPKCLGNVCSTSTYGLRCTPDRRQREAAARLGTPEIPAKFSTPKSHCKMIPQSIYEVELEMQESGLPKLRFKRTDSNSTIDMDVNKTPKISRKRKGDESPFNEKWCSKHAVRTEPACVSPSCVRTSHYTPGKSGIQTFICQSYTPNRCLSAAASPSQSDAGVPWTPSPKEKLSTDVINSWPRKKKASALCTNLLKCDKIPEYAEEDGGDFELEGVSKLLEKSPVIEQQSKVDGGTFGLRSRKRVFSLVSPTKETENPVKRVCTFNRHEDSSTATHRHQTKEEMEIFSSDQSRSSYLSSSQQSICDDVFNMSDFTPPSKVPKNPLSACGLLTLTQSPLLYKGKTPSSKRKEKIQDVFSDGDSDHGTPTLKRPTNPAAVSDDSPFRKVNPLRSISKTYSRKKLIT

Gene
TICRR
Protein
Treslin
Organism
Homo sapiens
Length
1910 amino acids
Function
Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation.
Similarity
Belongs to the treslin family.
Mass
210.857 kDa
Sequence
MACCHKVMLLLDTAGGAARHSRVRRAALRLLTYLSCRFGLARVHWAFKFFDSQGARSRPSRVSDFRELGSRSWEDFEEELEARLEDRAHLPGPAPRATHTHGALMETLLDYQWDRPEITSPTKPILRSSGRRLLDVESEAKEAEAALGGLVNAVFLLAPCPHSQRELLQFVSGCEAQAQRLPPTPKQVMEKLLPKRVREVMVARKITFYWVDTTEWSKLWESPDHLGYWTVCELLHHGGGTVLPSESFSWDFAQAGEMLLRSGIKLSSEPHLSPWISMLPTDATLNRLLYNSPEYEASFPRMEGMLFLPVEAGKEIQETWTVTLEPLAMHQRHFQKPVRIFLKGSVAQWSLPTSSTLGTDSWMLGSPEESTATQRLLFQQLVSRLTAEELHLVADVDPGEGRPPITGVISPLSASAMILTVCRTKEAEFQRHVLQTAVADSPRDTASLFSDVVDSILNQTHDSLADTASAASPVPEWAQQELGHTTPWSPAVVEKWFPFCNISGASSDLMESFGLLQAASANKEESSKTEGELIHCLAELYQRKSREESTIAHQEDSKKKRGVPRTPVRQKMNTMCRSLKMLNVARLNVKAQKLHPDGSPDVAGEKGIQKIPSGRTVDKLEDRGRTLRSSKPKDFKTEEELLSYIRENYQKTVATGEIMLYACARNMISTVKMFLKSKGTKELEVNCLNQVKSSLLKTSKSLRQNLGKKLDKEDKVRECQLQVFLRLEMCLQCPSINESTDDMEQVVEEVTDLLRMVCLTEDSAYLAEFLEEILRLYIDSIPKTLGNLYNSLGFVIPQKLAGVLPTDFFSDDSMTQENKSPLLSVPFLSSARRSVSGSPESDELQELRTRSAKKRRKNALIRHKSIAEVSQNLRQIEIPKVSKRATKKENSHPAPQQPSQPVKDTVQEVTKVRRNLFNQELLSPSKRSLKRGLPRSHSVSAVDGLEDKLDNFKKNKGYHKLLTKSVAETPVHKQISKRLLHRQIKGRSSDPGPDIGVVEESPEKGDEISLRRSPRIKQLSFSRTHSASFYSVSQPKSRSVQRVHSFQQDKSDQRENSPVQSIRSPKSLLFGAMSEMISPSEKGSARMKKRSRNTLDSEVPAAYQTPKKSHQKSLSFSKTTPRRISHTPQTPLYTPERLQKSPAKMTPTKQAAFKESLKDSSSPGHDSPLDSKITPQKRHTQAGEGTSLETKTPRTPKRQGTQPPGFLPNCTWPHSVNSSPESPSCPAPPTSSTAQPRRECLTPIRDPLRTPPRAAAFMGTPQNQTHQQPHVLRAARAEEPAQKLKDKAIKTPKRPGNSTVTSSPPVTPKKLFTSPLCDVSKKSPFRKSKIECPSPGELDQKEPQMSPSVAASLSCPVPSTPPELSQRATLDTVPPPPPSKVGKRCRKTSDPRRSIVECQPDASATPGVGTADSPAAPTDSRDDQKGLSLSPQSPPERRGYPGPGLRSDWHASSPLLITSDTEHVTLLSEAEHHGIGDLKSNVLSVEEGEGLRTADAEKSSLSHPGIPPSPPSCGPGSPLMPSRDVHCTTDGRQCQASAQLDNLPASAWHSTDSASPQTYEVELEMQASGLPKLRIKKIDPSSSLEAEPLSKEESSLGEESFLPALSMPRASRSLSKPEPTYVSPPCPRLSHSTPGKSRGQTYICQACTPTHGPSSTPSPFQTDGVPWTPSPKHSGKTTPDIIKDWPRRKRAVGCGAGSSSGRGEVGADLPGSLSLLESEGKDHGLELSIHRTPILEDFELEGVCQLPDQSPPRNSMPKAEEASSWGQFGLSSRKRVLLAKEEADRGAKRICDLREDSEVSKSKEGSPSWSAWQLPSTGDEEVFVSGSTPPPSCAVRSCLSASALQALTQSPLLFQGKTPSSQSKDPRDEDVDVLPSTVEDSPFSRAFSRRRPISRTYTRKKLMGTWLEDL

Gene
Ticrr
Protein
Treslin
Organism
Mus musculus
Length
1889 amino acids
Function
Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation (By similarity).
Similarity
Belongs to the treslin family.
Mass
208.335 kDa
Sequence
MACCHKVMLLVDTAGVSAPHSPARRAALRLLTYLSCRFGLARVHWTFKFFDSQGARSRPSRVSDFRELGSRSWEDFEEELEARLGDRPPGAHLPGPTPRATHTHGALMETLLDYQWDRPEITSPTKPILRSSGRRLLDADGEAREAQAALGGFGNAVFLLAPCPHSQRELLQFVSGCEAQAQRVPLTPKQVMEKVLPKRVQEVMIARNITLYWVDTTERSKLWASPDHVGYWTVCELLHHGGGTILPAETWSLGFTKARETVLPCGGELSHKPHPSPWISALPIDATVNCLLYNSEYEASFPRIEGTLFLPVQGKEIEETWAISLEPLAMHQRHFQKPVRIVLRGSVAQWSLPVSSALGTDSWMLQSPEEHRSTQRLLFQELVSRLTAEEFHLVASVDPGEGWPPITGIISPFSANAMILTVFRAKEAEFQSHFLQTAATEGSQDTASLFSDVVDSVLNQSHNLFEDPASSAPCVPEWVQQELSHTSSWSPALVEKWFPFSNASGATSDLMESFWLLHAASPDNDESSKTESELTRCLSELYQRSHEESTVVNQERSRKKRGIPRTPVRQKMNTMSRSLKMLNVARLNVKAQKLHPDGSPDTAVEKGLQKAVIGRTADKLEDRGRILRSSKLKEFKTEEELLAYIHDNYQKAVATEEITLYSCAQNMVSTIKMFLKSKDIKELEVACLSHVNSNLLKTSKTLRQNLAGKMDTEDKVGECQLQVFLRLEMCEQCPSVLDRPDEVERIVEEVTDLLRLVCLTKDSAYLSEFLEEILRLYIGSIPGTIGQLYHSLGLKIPQKLAGVLPTGFFSDDSMSQESMSPPPSSSTHRSVSAITESEQLEELRTRSAKKRRKNALIRHKSIAEISQTLRQIEVPKVSKRATRNENSHSASIQLPVPRKDTIQEVTKVRRNLFNQEMLSPSKRGLKKGLPRSHSVSALECLHHKQDKFKKTKSSTFQGYCKLLTKSVAETPVHKQISRRLLHRQIKGRSSDPGPDIHVVEESPEKEDEMTLRRSPRIKQLSFSRTNSGSFYSVSQPKSRSVQRIHSSQQESEQRENFPVQSIQSPKTLLFGALSEIPSSSKKGSAQIKRSLRSMLDSEISTSYETPKKSNQKSPSFSKTTPRRFPRTAQTLLYTPERLQNSPTEMTSAEGTISEATIKTPSSHGYNSPFASKVTSQKTVSPAKEETSPPLTKLPSTPRESDVQPPQCSSDCTWPHSVNSSPEGPYYPASPPPMAGQARSQCLTPIRYSFRTPPRTALAGTSKQQEHQELPLPRASQTQEPPQGLEKKALKIPKKPAHTSTSPLSPEEHYSGCDVSPHQPRNSLSASPPPGELNWKEHQTSPSVTSSVSCPVPSTPPRTPQRMTCPIPPSPPSKLRRSCRKKSCPPQDFPECHPGPSAAPVLSSATSPGAVTGSREEQSQFSEGQSYLGTGFRSDCHVSSPVLTASDTKCLPLIDEAQLHGLKNQEVKSGILPGEEGEEPESTIADELPSVSDPGILVPAPSSVSSSSELLPYPLCCTADGKQRQDAAQQGSPRASEATSSPQTYEVELEMQASGLPKLRIKKIDPGVLLEAEALGKEAPLGEEGALPALCMPKASKSSGRTEHPYLSPPCLRPSHSTPGKNGGQTFICQSCTPSRCPPSTPSPFQADAGVSWTPSPKQSGKTTPEIIKDWPRRKRAVDCSAGPSAGRGEASMDLPGSLSLLEPEPEGKERSLEQDLSKVLISEEFELEGVCQLPDQSPPKDSASVTEETSWGQFGLGRKRFLSAKEESEYKVKRVCDSLSEDPQASKQKECSPRWSALPLHSVGDDEVFVSGSTPPSGCMVRSCLSASGLQALTQSPLLFQGRTPSSHSTDTRDEEVDVFPSTAEESPFSHTLSRKRPFRTYTRKKLIS
Protein
Treslin: Ticrr

Gene
ticrr
Protein
Treslin
Organism
Danio rerio
Length
1824 amino acids
Function
Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with topbp1 by participating in cdk2-mediated loading of cdc45l onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation.
Similarity
Belongs to the treslin family.
Mass
201.945 kDa
Sequence
MASQNVVFAIDVDYRPEGTQNTTNAYQDHLKQWILRVLLSLGHRYGLEKVRWGYKFFNSRTVKSATLITRGSDFKELQEKVFSDFEEELHVKFTTEGKSPRSQEKSHKLKPSPACCVQNALKEILLDFQWDRPDLTSPTKVTLRPRRSSRSGRNIPLQDCDMLSVDKNVLFVVSECPRSKAELEDYLSMRREDSRHHKDINEQMLPKGLIDMLMQRNVVLHWADSGVFKADHVAKDYTGIETLMERLGLVGGQVVPMLSPCLPLMDQHPKMNSLLALGVDAFPIDSTNSYLHLSKRMQQQLFPPLGASFSWIADGTKRSCNVTLEPVSYRQRSLRAPVDVLLKGVLQSLDILSLSHSAIETWILQCPDAELGQEAFQHLKQLSTGGHAMLAEVSEGDVVCSAVLSVLSSCTAQITVLQPLLAQEGQLLPADLVSLDTTDISGDLPDVVSSVLSVMYDIMEEDDCSDHEKMPLVPDWANQELKQQSSSRSNGMVEGWFPLSDQSGISCHLMESMRLLHAAPEEKEKGEEYSDTQQEITSSLSEFYQSSTAGSSGSLRSKKRGTQCTPVRQKMKTMSRSLQMLNFARLNVKAQKTQGDSGSAGSGKGTEKGGKKSSGDRTKPGLLHFSSEEELLSHLGLTYQKAVENRTMSVPSQVQDLLSVVKSFLKSNTEASLLNLVQKHVLKSCQSIRQHYGNSSDDESKIRECQLQAVLRLELCKQTEQEDEEVVEQRVEDVADMLRNISRSKDAVYLSRFMQEEVLPLYMNSIPKVLADVYHSLGTQLPEALVAVLPSDFFSDESLAKDSVSVSLSSFSATQSNISSVGDHLEELRNRSAKKRRQSMITRHKSMTEAPQALRQIEMPRKSTRLAKPKLCVPIEKTAVEQPPLPKQPVQEVTKVRRNLFNQVTVSPSKKSKMPRSQSVSAVEGIKKRKRSDVDNDDRHTLLTKKVSETPLHKQVSSRLLHRQRTGRKSGESDVCIIEESPIKPAADLRRSPRIKSLTRRHSSVFYSSSQPRSRNLDRVVSSSQLSHSEGKGKFSVSSVRSPVRLLFGATQSPGRLRHTTVSSLEDQASKGLPLRCSSFENQNKTPQKLRSDALASAVGCRTPQSPRTPNRTVGDNGMALRGSPFQSPAAKSIVVETPMKSPLKGILKTPIKKSLLDCVSPNGAWLRSPGCKTPKKCVTWSPSPRKPVPENQVNVPDSPVFAKRHSPRLVTPGKNSSPEEKIVFKTPDKVPQRKSKTSPEIILRRLEIPVNIDPETCKSITRSGKIRTLSLPYKTSKGSDEFLPQSESGSFPFCNSPLKPNIQKTIQSPIPTHRMCTRSGNTPVKESCSPSSNSQGITGTSPSPRKSLSSAVAKSSPSPSFGPSRSGVGNQNNSSISNVEKHTDDDKIIVQNKANDEKAEEASSSDSQQFDCSEFSITTDDESIDISEAAVVKTQLVGGIKMNIAFSRKPSKSDVFEFEGKQTTSTGTPLTRSYGFRQTPDRRQREAEARLGYSSGKPKISTPRTRRTPACGKQSSPQPLTYEVEMEMQASGLPKLKLRRTDSFNAGDLPSSATKGMTSHLVHRNKTNLKAPQIDSPLVQSSRHPGCISPSLCSRATPAKGTPGKGVQTYICQSITPTHHPTSSQSPLASPLTPSPQSRGWPTPENLNSWPRKKRARIETCGNKEQVIKGVPLLEKTGVIEDPELEGIFRIQGVEELKESLSTPISQRKLGLRSSQVMDHQGSPEGMDWTETMAQMCDAKDSTKTEQFAWMGRKVDTPKVKKQVSASGIFALTQSPLLYKKSAVIKEATQFSGSKSELEISPLCQPRRRRTPSRTYSRKKLLD
Protein
Treslin: ticrr