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thyA2

Gene
thyA2
Protein
Thymidylate synthase 2
Organism
Bacillus amyloliquefaciens
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.35 kDa
Sequence
MKQYKDLCRHVLENGEKKGDRTGTGTISTFGYQMRFNLQGGFPMLTTKKLHFKSIAHELLWFLKGDTNVRYLQENGVRIWNEWADENGELGPVYGSQWRSWRGADGETIDQISRLIHDIKTNPNSRRLIVSAWNVGEIDRMALPPCHCLFQFYVADGKLSCQLYQRSADVFLGVPFNIASYALLTMMIAHVTGLEPGEFVHTFGDVHIYQNHVEQVNLQLTRDVRPLPKLRFARNVDSIFDFAFEDFIIEDYDPHPHIKGAVSV

Gene
thyA2
Protein
Thymidylate synthase 2
Organism
Bacillus subtilis subsp. spizizenii (strain ATCC 23059 / NRRL B-14472 / W23)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.504 kDa
Sequence
MKQYKDLCRHVLEHGEKKGDRTGTGTISTFGYQMRFHLQEGFPMLTTKKLHFKSIAHELLWFLKGDTNVRYLQENGVRIWNEWADENGELGPVYGSQWRSWRGADGETIDQISRLIEDIKTNPNSRRLIVSAWNVGEIDKMALPPCHCLFQFYVSDGKLSCQLYQRSADVFLGVPFNIASYALLTMMIAHVTGLEPGEFIHTFGDVHIYQNHIEQVNLQLTRDVRPLPKLRFAREIDSIFNFAFEDFIIEDYDPHPHIKGAVSV

Gene
thyA2
Protein
Thymidylate synthase 2
Organism
Bacillus subtilis (strain 168)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.538 kDa
Sequence
MKQYKDFCRHVLEHGEKKGDRTGTGTISTFGYQMRFNLREGFPMLTTKKLHFKSIAHELLWFLKGDTNVRYLQENGVRIWNEWADENGELGPVYGSQWRSWRGADGETIDQISRLIEDIKTNPNSRRLIVSAWNVGEIDKMALPPCHCLFQFYVSDGKLSCQLYQRSADVFLGVPFNIASYALLTMIIAHVTGLEPGEFIHTFGDVHIYQNHIEQVNLQLERDVRPLPQLRFARKVDSIFNFAFEDFIIEDYDPHPHIKGAVSV