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thoc6

Gene
thoc6
Protein
THO complex subunit 6
Organism
Drosophila melanogaster
Length
350 amino acids
Function
The THO complex is required for cell proliferation and for proper export of heat-shock mRNAs under heat stress.
Similarity
Belongs to the WD repeat THOC6 family.
Mass
39.221 kDa
Sequence
MKQKDLKRAYNNVLAQAISGSKQYLFAGNLFGDIFVLRIKELDKGSEEPPGKLKIFPQGSDVDINYLAFHRDFLIVGAVGLIYGLEWNEEEESLATKRSWEVKIPMQVDAVEVPDVNSMWLDSENSILFAGCGDGVIYQVSLEDGRIQREYRGHTDYVHSVVGNANGQIFSGAEDGTVRVWSTKQQQHTSMLEPYKNPNLLRPDWGKWIGAVAVNEDWLLCGGGPKASIFHLRSMESTCVFSFPGRVHLCDFVDDCVLIGGEHNHVQSYTLNGVLQANIPVEHTACYSAVWQTSPIKFISIAGFSNKLHILKDFRFLDSKIEMYGNVEGEENDPEEEDELIEKPLTVEAA

Gene
THOC6
Protein
THO complex subunit 6 homolog
Organism
Homo sapiens
Length
341 amino acids
Function
Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Plays a role in apoptosis negative control involved in brain development.
Similarity
Belongs to the WD repeat THOC6 family.
Mass
37.535 kDa
Sequence
MERAVPLAVPLGQTEVFQALQRLHMTIFSQSVSPCGKFLAAGNNYGQIAIFSLSSALSSEAKEESKKPVVTFQAHDGPVYSMVSTDRHLLSAGDGEVKAWLWAEMLKKGCKELWRRQPPYRTSLEVPEINALLLVPKENSLILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWDLRTAKEVQTIEVYKHEECSRPHNGRWIGCLATDSDWMVCGGGPALTLWHLRSSTPTTIFPIRAPQKHVTFYQDLILSAGQGRCVNQWQLSGELKAQVPGSSPGLLSLSLNQQPAAPECKVLTAAGNSCRVDVFTNLGYRAFSLSF

Gene
Thoc6
Protein
THO complex subunit 6 homolog
Organism
Mus musculus
Length
341 amino acids
Function
Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway.Plays a role in apoptosis negative control involved in brain development (By similarity).
Similarity
Belongs to the WD repeat THOC6 family.
Mass
37.315 kDa
Sequence
MEHAAPLAVPLGQAEVFQALQRLHMTIFSQSVSPCGKFLAAGNNYGQIAIFSLSAALSSEAKEESKKPVVVFHAHDGPVYSMVSTDRHLLSAGDGEVKGWLWAEILKKGCKELWRRQPPYRTSLEVPEINALLLVPKENSLILAGGDCQLHSMDLETGAFTRALRGHTDYIHCLALRERSPEVLSGGEDGAVRLWDLRIAKEVQTIEVYKHEECSRPHNGRWIGCLATDSDWMVCGGGPALTLWHLRSSTPTTVFPIRAPQKHVTFYQDLILSAGQGCCVNHWQLSGELKAQVPGSSPGLLSLSLNQQPAAPECKVLTASGNSCRVDVFTNLGYRAFSLSF

Gene
Thoc6
Protein
THO complex subunit 6 homolog
Organism
Rattus norvegicus
Length
341 amino acids
Function
Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. Plays a role in apoptosis negative control involved in brain development (By similarity).
Similarity
Belongs to the WD repeat THOC6 family.
Mass
37.423 kDa
Sequence
MEHATPLAVPLGQAEVFQALQRLHMTIFSQSVSPCGKFLAAGNNYGQIAIFSLSAALSSEAKEESKKPMVTFHAHDGPVYSMVSTDRHLLSAGDGEVKGWLWAEILKKGCKELWRRQPPYRTSLEVPEINALLLVPKENSLILAGGDCQLHTMDLETGTFTRALRGHTDYIHCLALRERSPEVLSGGEDGAVRLWDLRIAKEVQTIEVYKHEECSRPHNGRWIGCLATDSDWMVCGGGPALTLWHLRSSTPTTVFPIRAPQKHVTFYQDLILSAGQGCCVNHWQLSGELKAQVPGSSPGLLSLSLNQQPAAPECKVLTASGNSCRVDVFTNLGYRAFSLSF

Gene
thoc6
Protein
THO complex subunit 6 homolog
Organism
Danio rerio
Length
323 amino acids
Function
Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway (By similarity).
Similarity
Belongs to the WD repeat THOC6 family.
Mass
35.368 kDa
Sequence
MGPVELLHMSVFSQSFSPCGRYLAAGNNYGEIAVFSLSAALSPDASERSQKPILNFTAHDGPVFSLLSTESHLLSAGNGEISAWSWAELIKKSTKAAWTRKPNYETSLEIPEINAMIINPKDNNLIVGGGDNNIHIMDMETGTFKSVLKGHTDYIHCLSFKEREGEILSGGEDGAVRIWDSRTNRPVHCIEVFKYEECARPQFGKWISCLATDSDWMLCGGGPSLSLWHLRSMSPTSVFPLSGCQREAVSYQDLIMSVGEGPYVSHCLHGGTVKAQIPCSPSSLNTLALNLKNTEHRVMTVGGSSHQIDVFTNFSYRALSLSF