Protein
Thiamine biosynthesis multifunctional protein ThiED
Organism
Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Function
Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.
Similarity
In the C-terminal section; belongs to the thiaminase-2 family.
Sequence
MTDFSLYLVTDPHLGGGPERVAGIVEDAINGGVTVVQLRDKDADEQTFREHAMELKRVCDRLGVPLFLNDRFAVAAELSCHVHIGQGDLPYVQARRQLPGHLMIGLTIETMDQLETVIADCTRAGIALPDVVGLGPVQATDTKPDAPQAVGVDGVAAMAKVARAHGIASVAIGGVGLANAADLARTGVDGLCVVSAIMAAPSPAEAARELLDVWEAGRRVAQPRVLTIAGTDPTGGAGVQADLKSIAAAGGFGMSVITALVAQNTHGVTGVHTPPADFLDEQLESVFSDVTVDAVKLGMLGRADTVRQVTGWLRTRPHGPVILDPVMVATSGDSLLDPDATEALLELATVVDVITPNIPELAVLCGEQPAPSFDAAIEQARRFATDVGTTVIVKGGHLTGPRADNAVVYPDGSVHMVANPRVDTTNSHGTGCSLSAALATRMGAGHPVDKALDWATRWLNEALRGADALQVGSGSGPVDHFAVTRRLLRAADATPWPHLRMGAPSDGIITPSDTQSPAPALAPAGPYTRALWEATGDVLGEILDSGFIRGLGDGTLSREEFLFYIDQDAHYLRQYSRALATLSSRAPDAPAQVDWATSAAECITVEAELHRTYLNKGLAETGVSAPSPVTMAYTDFLIARSHADDYVVGAAAVLPCYWLYAEIGLILAKQNHPEHPYTDWLDTYSGEGFLAGTVKAIARVEAAMAGAGPDQQRVAAQTYLSACVHEREFFDQATRQGWN