About Products Protein Database Contact

thi2

Gene
THI2
Protein
Thiamine biosynthesis regulatory protein
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
450 amino acids
Function
Positive regulator of thiamine biosynthesis.
Mass
51.823 kDa
Sequence
MVNSKRQQRSKKVASSSKVPPTKGRTFTGCWACRFKKRRCDENRPICSLCAKHGDNCSYDIRLMWLEENIYKVRKHSLISSLQARKSKSKPLCQKISKSRFKQMTHFRQLSPPTSDCEDSVHEASKETTLPNDNTFTISVRRLKIYNNAVASVFGSMTNRDYTQKRIDKKLDELLNMVENDISVVNLNCSKHGPYSVFRANPAAVTSALTDQLPSPGHSMSSAEETTTAALSSPPEDSTSLIDIIQGKIFGILWFNCYGNMILNRQEYTTWFINKMRNSLTTEFIRFLGKIIDDPDINMASCLFKECIARWSCVDWQSIAITMLVIIHGYTCPNLTKLLRVWFLQQKLLRFSMYPLVNFIINNTQDLDVLYHCNGLLGNADLFEDPYQDELTSELHVLVTERLVNSWKDTILQQLCSCQDTTLSCSQLRYWQLQLKCNQQFYKDVYAMQD

Gene
THI2
Protein
Thiamine thiazole synthase
Organism
Uromyces fabae
Length
338 amino acids
Function
Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance.
Similarity
Belongs to the THI4 family.
Mass
36.213 kDa
Sequence
MSPVATESMYKPTTINQTAHQQAMDPLKSKQQSNATVNKPAFKPEPAVNLTPIKFAPIKEHQVQRAMVRRYFQDMEERAISDVIIVGAGSAGLSCAYALGTARPDLKITILESNVAPGGGCWLGGQLMSAMVCRKPADEFLDQVGVPYEDEGNFVVVKHAALFTSTVLSKVLAMPNVKMFNATACEDLIIKPCPINPGVQRIAGCVTNWTLVSLNHDHQSCMDPSTITAPLVCSFAGHDGPFGAFCVKRVASAGLSEGLGDMRPLDMERAEDHIANKTREILPGLIVGGMELSEFDGSARMGPTFGAMLLSGKRAAEVALQSLDRVKIEEGEVVGLAK

Gene
thi2
Protein
Thiamine thiazole synthase
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
328 amino acids
Function
Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance.
Similarity
Belongs to the THI4 family.
Mass
35.274 kDa
Sequence
MAPATAVVTPQTAFKTDLPVEKTAHNTVVKSEMGALSKAYPTYSLDESFSFAPIRESTVSRAMTRRYFSDLDKYAESDIVIVGAGSAGLTAAYYIGTRRPDLKIAIIEASVAPGGGAWLGGQLFSAMVVRKPADLFLNEIGVPYEDEGDYVVVKHAALFTSTVMARTLALPNVKLFNATAVEDLIVKEGKDGKQRIAGVVTNWTLVSLNHGLQSCMDPNTINAHLVVSATGHDGPFGAFCVKRLASAQLVSNLHDMRPLDMNRAEDLIVKGTREVFPGMIVGGMELSEFDGANRMGPTFGGMMFSGIKAAQEALAIFDERKAVNEKYL

Gene
THI2
Protein
Thionin
Organism
Brassica rapa subsp. pekinensis
Length
133 amino acids
Function
Thionins are small plant proteins which are toxic to animal cells. They seem to exert their toxic effect at the level of the cell membrane. Their precise function is not known.
Similarity
Belongs to the plant thionin (TC 1.C.44.1) family.
Mass
13.961 kDa
Sequence
MEGKTVILGVIIMSLVMAQNQVEAKICCPRTIDRNIYNACRLTGASMTNCANLSGCKIVSGTTCPPGYTHDILQNYGDAVNEYCKLGCASSVCGALTTLKNSMQVNCEGAVSQCTNACSNFCTKGSAKVVETA

Gene
THI2
Protein
Crambin
Organism
Crambe hispanica subsp. abyssinica
Length
46 amino acids
Function
The function of this hydrophobic plant seed protein is not known.
Similarity
Belongs to the plant thionin (TC 1.C.44) family.
Mass
4.736 kDa
Sequence
TTCCPSIVARSNFNVCRLPGTPEALCATYTGCIIIPGATCPGDYAN