Protein
Thiamine biosynthesis multifunctional protein ThiED
Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Function
Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.
Similarity
In the C-terminal section; belongs to the thiaminase-2 family.
Sequence
MTDFSLYLVTDPVLGGGPEKVAGIVDSAISGGVSVVQLRDKNSGVEDVRAAAKELKELCDARGVALVVNDYLDIAVELGLHLHIGQGDTPYTQARELLPAHLELGLSIENLDQLHAVIAQCAETGVALPDVIGIGPVASTATKPDAAPALGVEGIAEIAAVAQDHGIASVAIGGVGLRNAAELAATPIDGLCVVSEIMTAANPAAAATRLRTAFQPTFSPETQTELSQTELQGAFVNSPSAPRVLSIAGTDPTGGAGIQADLKSIAAGGGYGMCVVTSLVAQNTHGVNTIHTPPLTFLEEQLEAVFSDVTVDAIKLGMLGSADTVDLVASWLGSHEHGPVVLDPVMIATSGDRLLDASAEESLRRLAVHVDVVTPNIPELAVLCDSAPAITMDEAIAQAQGFARTHDTIVIVKGGHLTGALADNAVVRPDGSVFQVENLRVNTTNSHGTGCSLSASLATKIAAGESVEKALEWSTRWLNEALRHADHLAVGTGNGPVDHGHLARRMTHAAETTPWAHLRAPRLDGATAASFTTPSTVKSPAPRIEPAGPFTRALWEASGDIIAGINSSDFITMLGDGTLRRPEFDFYIDQDAQYLAQYSRALARLSSIAPDSHAQIEWAQSAAECLVVEAELHRSYMAGKEVSAPSHITMAYTDFLIARTYTEDYVCGVAAVLPCYWLYAEIGLMLAEQNHDEHPYKDWLNTYSGEEFIAGTRAAIARLEKALENAGAEQRVDAARAFLSASVHEREFFDQATRHGWTMVGSS