Protein
THAP domain-containing protein 1 A
Function
DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes (By similarity).
Similarity
Belongs to the THAP1 family.
Sequence
MVQSCSAYGCKNRYDKDKPISFHKFPLKRPLLCKKWEAAVRRAEFKPTKYSSICSDHFSADCFKRECNNKLLKDNAVPTIFAHMEIKKKSGKAVKKEQLPAEPEPVPAVPEIDPAIGLLLPPLYTPSHIAVICDHNYTVEDTVHQRRRIQQLEEQVDKLRKKLKIANQKCRRQERSLEKLEREVSEYREAKGSGYVIFPGNYYEVLNENEYKELTPEITYKEIIL