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tgt-2

Gene
tgt-2
Protein
Queuine tRNA-ribosyltransferase accessory subunit 2
Organism
Caenorhabditis briggsae
Length
376 amino acids
Function
Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
Similarity
Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.
Mass
42.106 kDa
Sequence
MVKFSIEKKTILGRLGKIDSWGPVDVNHATPSCMTYLRAGHIPHLTWDVAENQLKLSQTPIYQMTLPSLISNAKIIEKFGKGVAKFVGMGALESPAIHLSPFDPLGKLPSGYNDSKSIAIWTANGKVSLDVKTYRNTVNSFGCGSFETLVDYDLPRDAGHKKLLKAVDRTTTFNEQIFKQDEKIDGERIVALGGGFSKYHRRKCAVDIGLAENTAAYTVEFHEFVEGMETDEMEMKELLEETFSPLPPTKLRCISGPFNPKTVLFLVQQGIDLFDSSFAIKLAEEGHAFCLADDYPTSSKYEVVDFKDQEKFADDFTPVFDGCGCYTCTKYTKGYLQHLLNTKELLASILLVIHNMSEYDRMFKLIRKSLENSEGL

Gene
tgt-2
Protein
Queuine tRNA-ribosyltransferase accessory subunit 2
Organism
Caenorhabditis elegans
Length
373 amino acids
Function
Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
Similarity
Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.
Mass
41.913 kDa
Sequence
MVKFQIEKKTLLGRLGKIDTWGSVEVNHQTPSFQTYLRAGHIPHLTWEVAENQLKLEQTHIFQMTLPTLVSNAKIIEKFGKGAAKFCGMPAGAAVHLTPFDPLGKLPGGYNDSKSVAIWTANGKVSLDVKMWREIINSFGCGSIETLVDYDTPKDVGQKKLVKAVDRTKTFQEQLFQQDEKVNGERIVSLGGGFSKYHRRKCAVDVGLAENIAGYTVEFREFTEGKETDDKEMKELLEETFSPLPPTKLRCISGPFNPKTVLFLVQQGIDLFDSSFPVKLAEEGHAFCLSDDFPTSSKYEVVDFNNEKFADDFTALFDGCACYTCTKYTKGYLQHLLNTRELLASILLVIHNMTEYDKMFKLIRSSLENSEGL