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tfap2e

Gene
TFAP2E
Protein
Transcription factor AP-2-epsilon
Organism
Homo sapiens
Length
442 amino acids
Function
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-epsilon may play a role in the development of the CNS and in cartilage differentiation (By similarity).
Similarity
Belongs to the AP-2 family.
Mass
46.212 kDa
Sequence
MLVHTYSAMERPDGLGAAAGGARLSSLPQAAYGPAPPLCHTPAATAAAEFQPPYFPPPYPQPPLPYGQAPDAAAAFPHLAGDPYGGLAPLAQPQPPQAAWAAPRAAARAHEEPPGLLAPPARALGLDPRRDYATAVPRLLHGLADGAHGLADAPLGLPGLAAAPGLEDLQAMDEPGMSLLDQSVIKKVPIPSKASSLSALSLAKDSLVGGITNPGEVFCSVPGRLSLLSSTSKYKVTVGEVQRRLSPPECLNASLLGGVLRRAKSKNGGRCLRERLEKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYVCETEFPAKAAAEYLCRQHADPGELHSRKSMLLAAKQICKEFADLMAQDRSPLGNSRPALILEPGVQSCLTHFSLITHGFGGPAICAALTAFQNYLLESLKGLDKMFLSSVGSGHGETKASEKDAKHRK

Gene
Tfap2e
Protein
Transcription factor AP-2-epsilon
Organism
Mus musculus
Length
442 amino acids
Function
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-epsilon may play a role in the development of the CNS and in cartilage differentiation.
Similarity
Belongs to the AP-2 family.
Mass
46.283 kDa
Sequence
MLVHTYSAMERPDGLGAAAGGTRLSSLPQAAYGPAPPLCHTPAASATADYHPPYFPPPYPQAPLPYGQGPDATAAFPHLAADPYGGLAPLAQPQPPQAAWAAPRAAARAHDEPPGLLAPPARALGLDPRRDYAAAVPRLLHSLADGAHGLADAPLGLPGLAEPPGLEELQAIDDPGMSLLDQSVIKKVPIPSKAGSLSTLALSKDSLVGGISNPSEVFCSVPGRLSLLSSTSKYKVTVGEVQRRLSPPECLNASLLGGVLRRAKSKNGGRCLRERLEKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYVCETEFPAKAAAEYLCRQHADPGELHSRKSMLLAAKQICKEFADLMAQDRSPLGNSRPALILEPGVQSCLTHFSLITHGFGGPAICAALTAFQNYLLESLKGLEKMFLSGAGGGHGESKASEKDTKHRK

Gene
tfap2e
Protein
Transcription factor AP-2-epsilon
Organism
Xenopus laevis
Length
434 amino acids
Function
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions (By similarity).
Similarity
Belongs to the AP-2 family.
Mass
47.05 kDa
Sequence
MLVHAYSAMDRSEVLNGAASGGRLSQLSSLNQGPYSSAPPLCHTPASDFQPPYFPPPYPQPPLSYSQSQESGYPHLGDPYSSINSIHHQHQQPSWHTPRSRPEEAGLLSQTHRGLSLDPRRDYGGMSRLIPGLTDGGHSLADSSLSIHALSHHSLEDMQLLDESGISILDQSVIKKVPISSKNNSSMMSALSMNKESLIGGVSNPNEVFCSVPGRLSLLSSTSKYKVTVGEVQRRLSPPECLNASLLGGVLRRAKSKNGGRCLRERLEKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYVCETEFPAKAAAEYLCRQHSDPTELHARKNMLLATKQICKEFADLLAQDRSPLGNSRPSLILEPGVQSCLTHFSLITHGFGGPAICAALTAFQNYLLESLKGMDKIFMSSTGNGHSAAESKSEKDIKHRK

Gene
tfap2e
Protein
Transcription factor AP-2-epsilon
Organism
Danio rerio
Length
423 amino acids
Function
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions.
Similarity
Belongs to the AP-2 family.
Mass
45.514 kDa
Sequence
MLVHSYSSMERADGLSSSSPGGRLSQLNQAAYSSAPPLCHTPASDFQPPYFPPPYPQSSLSYSQSQDGGYPHLPEPYPSLNSLHQHQQAAWHSQRSRSEDAGLLSQPHRALSLDPRREYPGVPRLLTHGLGDGAAALGDGPLGMHAVHHGLDDIQGLEEASALGILDHSVIKKVPLPSKLNGSTISALSLSKEGLGLGGVSNPAEVFCSVPGRLSLLSSTSKYKVTVGEVQRRLAPPECLNASLLGGVLRRAKSKNGGRCLRERLEKIGLNLPAGRRKAANVTLLTALVEGEAVHLARDFGYVCETEFPARATAEYLCRQTEPDQLPTRRSMLLATKEICKEFVDLMSQDRSPLGASRPTPCLEPGVQSSLTHFSLLTHGFGTPALCAALSAFQSYLLEALKLLDKGENGGKNHHDKELKHRK