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telo2

Gene
Telo2
Protein
Telomere length regulation protein TEL2 homolog
Organism
Mus musculus
Length
840 amino acids
Function
Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation (By similarity).
Similarity
Belongs to the TEL2 family.
Mass
93.313 kDa
Sequence
MDPALSAVRLTVQEAIHILSSSEDAGHILSTLGTLKRYLGGTEDPVLPEEKEEFATVHFSAVLRCLVSKLSPGWLELSPGGQLERLWESFFLDGPPDQAFLVLMEAIESTAGPSFRLMKMAQLLDTFLSTGRVAALMEEQCRPQTKPSFPLFQETLLSKVVGLPDLLGNCLQRDNLTQFFPQNYFPLLGQEVVQALKAVVNFLQDGLDCSVSFVSRVLGKVCIQGRKREILSVLVPQLTVLTQDSCLWQRVCWRLVEQVPDRAVEAVLTGLVEAAPRPEVLSRLLGNLVVKNKKARFVVTRKLLLLQYQHTTPMVQSLLGYLALDSQRRPLLIQVLKELLETWGCSSAVRHTPLEQQCYISKAILVCLAHLGEPELQDIRDELLASMMAGVKCRLDSSLPPVRRLGMIVAEVISSRIHPEGPLLKFQYEDDEMSRELLALATPEPAGDCSSVSRGPSPAPVDTESPVEMPEKAVESDVPPTQPQGSDSELDSDDEFIPYDMSGDRELKSSKEPLYIRDCVEALTTSEDMERWEASLKGLEGLVYRSPTATREVSVELAKVLLHLEEKTCVAEFEQLRQSALVAVTVTDPEQVAKYLTSQFYGLNYSLRQRMDILDVLVLAAQALSRPKSLQRRSQHGPPVPGTMCSPALAVSQTGNVAAPDWQVVVEERIRSKTRRFSKGCPQRELSGVPNEFSSVAGYFFFPLLQHFDRPLVTFDLLGDDQLVLGRLTHTLASLMYLAVNTTVAVPMGKALLEFVWALRFHVDIYVRRGLLSAVSSVLLSVPTERLLGDLPDELLEARSWLADVAEKDVDEDCRELAVRALLLLERLKDKLLSSSSPQP

Gene
TELO2
Protein
Telomere length regulation protein TEL2 homolog
Organism
Homo sapiens
Length
837 amino acids
Function
Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation.
Similarity
Belongs to the TEL2 family.
Mass
91.747 kDa
Sequence
MEPAPSEVRLAVREAIHALSSSEDGGHIFCTLESLKRYLGEMEPPALPREKEEFASAHFSPVLRCLASRLSPAWLELLPHGRLEELWASFFLEGPADQAFLVLMETIEGAAGPSFRLMKMARLLARFLREGRLAVLMEAQCRQQTQPGFILLRETLLGKVVALPDHLGNRLQQENLAEFFPQNYFRLLGEEVVRVLQAVVDSLQGGLDSSVSFVSQVLGKACVHGRQQEILGVLVPRLAALTQGSYLHQRVCWRLVEQVPDRAMEAVLTGLVEAALGPEVLSRLLGNLVVKNKKAQFVMTQKLLFLQSRLTTPMLQSLLGHLAMDSQRRPLLLQVLKELLETWGSSSAIRHTPLPQQRHVSKAVLICLAQLGEPELRDSRDELLASMMAGVKCRLDSSLPPVRRLGMIVAEVVSARIHPEGPPLKFQYEEDELSLELLALASPQPAGDGASEAGTSLVPATAEPPAETPAEIVDGGVPQAQLAGSDSDLDSDDEFVPYDMSGDRELKSSKAPAYVRDCVEALTTSEDIERWEAALRALEGLVYRSPTATREVSVELAKVLLHLEEKTCVVGFAGLRQRALVAVTVTDPAPVADYLTSQFYALNYSLRQRMDILDVLTLAAQELSRPGCLGRTPQPGSPSPNTPCLPEAAVSQPGSAVASDWRVVVEERIRSKTQRLSKGGPRQGPAGSPSRFNSVAGHFFFPLLQRFDRPLVTFDLLGEDQLVLGRLAHTLGALMCLAVNTTVAVAMGKALLEFVWALRFHIDAYVRQGLLSAVSSVLLSLPAARLLEDLMDELLEARSWLADVAEKDPDEDCRTLALRALLLLQRLKNRLLPPASP

Gene
telo2
Protein
Telomere length regulation protein TEL2 homolog
Organism
Xenopus laevis
Length
835 amino acids
Function
Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. Promotes assembly, stabilizes and maintains the activity of TORC complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation (By similarity).
Similarity
Belongs to the TEL2 family.
Mass
93.679 kDa
Sequence
MDASQADRKVAPVSAVVKNAICELSRINDGERLMEVLLSLKCYLGTRENSTQTQEHAEFNRNHYTPFLEFLVAQMGPQWLDLLTLEKLELWDSFFLEGPADQAFLVLMDSLGKTGPSIRLDRCVHVLERFLQRGALAEVIREVCQQQLESNPTAVLHEAILGRISSLPDHLANCLQQHNKPVFYPNNYYPLLAGSIISVLQMVSDALRDGKNCSISFASQVVGKVCMQGRQKELLSVLVPRLKSLVQSDCIWQRICWRLVESVPDRWMEPVVIGIVQMAPGAEFLSQLLGDLVVKNKRTQFLLTKKMLFLQYGLKKDALQSILGYLSLDASRRYLLVKILRELLEVWSSGSVLKNSSQPQLLHVSRCLLICLGLLNKQEIESCKQDLLVSLTSGARNYLDSSVPAIRRMGMVVAECLSHRIDTEGPGLSFQYEEDEDTRDLKALLKPPHVFEADSADCVKNPEESSPSKSCPKAIEKSKMEAKADQASDSELDSDDDLAPYDMSADTELKKSKAPAYIRDCIEVLLSDDVEKLEVTMTCLATLIQANTSATKEVSVELTKILLHIDDKPSVERFTELRHAALVAVAVTDPVPVSQYLTGEFYSLNYSLRQRMDILDVLSSAAQSLSEKLSHEVSSESRSTGTGQHSIRSTTWTLAEAPADWRKVVEERIASKTRRFSKGQSVPTPVPAPNRYHAVAGHLFFPLIQNYDRQIVTFDLLGEDRLVLGRMVHTLGILMHLALHAPIASQMGKALLEFVWVLRFHIDAFVRQGLLFCISTVLLSVPWERLMTDMAEEVMETQSWLADVAERDSDDDCRRLALNGLFLMEKLRNNIHGTP

Gene
telo2
Protein
Telomere length regulation protein TEL2 homolog
Organism
Xenopus tropicalis
Length
829 amino acids
Function
Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. Promotes assembly, stabilizes and maintains the activity of TORC complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation (By similarity).
Similarity
Belongs to the TEL2 family.
Mass
92.822 kDa
Sequence
MAPVSTVVKNAISDLAKISDGERLREALLSLKSYLGTGENSAQTQETTEFNRNHYTPVLEFLVAQIGPQWLDLLTSERLELWDSFFLEGPPDQAFLVLMDSLGKTGPSIRLDRCVHVLERFLQRGALAEVIWEVCQQQLESNPTSVLHEAILGRISSLPDHLANCLQQHNKPLFYPKNYYPRLAGSIIRVLQMVSDALRDGKNCSISFASQVVGKVCMQGRQKELLSVLVPRLKSLVQSDCIWQRICWRLLESVPDRWMEPVLTGIVQTAPGAEVLSQLLGDLVVKNKRTQFLLTKKMLFLQYGLKKDALQSILGYLSLDASRRHLLVKVLRELLEVWSSGSVVKHSPHPQLLHVSRCLLICLGLLNKQEIESCKQDLLVSLTSGARNYLDSSVPTTRRMGMVVAECLSHHIDTEGPGLSFQYEEDEDTRDLKALLKPPHMVETDSADFVKRPVESSPSKSPLSSPEVREKSKVKVKADQASDSDLDSDDDLVPYDMSADTELKKSKAPAYIRDCIEVLLSDDVEKLEVTMASLATLIQANTLATKEVSMELAKILLHIDEKPSVARFTELRHAALVAVTVTDPVTVSQYLTSEFYSLNYSLRQRMDILDVLSSAAQSLSEKPSHETSAESGSVNTDPHSIRSTAWTSSEVPVNWRKVVEERIASKTRRFAKGHSAATPVPAPNRYHAVAGHFFFPLIQNYDRQIVTFDLLGEDRLVLGRMVHTLGILMHLTLNAPIASQMGKALLEFVWVLRSHTDAFVRQGLLFCISTVLLSVPWEHLMTDMAEEVVETQCWLAEVAERDSDDDCRRLALNGLFLMEKLRSNIQGNP

Gene
telo2
Protein
Telomere length regulation protein TEL2 homolog
Organism
Danio rerio
Length
822 amino acids
Function
Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. Promotes assembly, stabilizes and maintains the activity of TORC complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation (By similarity).
Similarity
Belongs to the TEL2 family.
Mass
91.669 kDa
Sequence
MGTFGTESPLRLQVSSCLKTLSTSRDSGEIVHALRTLMRCLDDGEFTRIHHTHALQVLVSAQSSHWFSRSHDEDEEEMKKLWGEIIIRGPAEQTLLTLLDTISSTGESEALDRCVSALEMFLSAARLQVLLWSRCEVSGASADSPQLTETVIGHLAALPSITSNHLHTNTPDIFLPQQYYPLLAASILDTLEKTCHALRAGRDCSLGFVSQVLGKVCIQGYSSQMFETLGPRLSFVTREDALYQRVTQKLMENVPERCTESVITGLIRSLSGAAAVSRLMGNLVLTNKKAQFVLTHKLILQQYQHPTRLLKSVLGYLAVDSSRRPLLKQVLRSVCQVWCNSSAVKHTCVEQQLYVSKALLLCVALLDDSEIQELRQEMLQCMLGGVQCRLDSNVERIRRMGMVVGECLSHRLDTPGSQLKFQYGADEEIGELKSLMESLAVNDDEEEQPDASNSLQPEPKVEAPVSSQSVASDPGNGSESELDSDDDLTPYDMSADQEKKKSAPPRYVRDCLEGLMSSDDAERFELSLQVAETLLRKNVKATQEVSVQFSKVLLHLEDRYNTALFLSLRQNAMVALTVTDIKPVVDYWTTEFYALNYSLRQRLDILEVLALAAQELSEPVTNKHTGAEPITAVTPLGQSDDITHWRQIVDKRIQSKTRRISKGVTQPVKAVPNRYAPVAGFFFFPLFRSYDRPQTTFDLLGGDHLVLGRLLHTLGLLMHLAVNAPVVSQMGRALLDFVWAVRFHTDQMVRRGVMFAVCAVFLSMPSENLLTELGDDLMETRAWLADVAESDCDSDCRSLAVQSLMLMDKNLKSQLQIPDMET