tdo2a

Tryptophan 2,3-dioxygenase A

406 amino acids

Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.

Belongs to the tryptophan 2,3-dioxygenase family.

48.045 kDa

MSGCPYFQRKFLSTSKQHLKEEENDEAQTGINKASKGGLIYGDYLQLDKIVTSQVLQSELKGNKIHDEHLFIVTHQAYELWFKQVLWELDSVREIFISGHVRDERNMLKVNTRIHRIVMIFRLLLDQFAVLETMTALDFYDFREYLSPASGFQSLQFRLLENKIGVPHNQRVPYNRRHYRDNFRDQESELLLHSEQEPTLLQLVEQWLERTPGLEEDGFNFWGKLEKNIFEGLRREKEHIEQKPASERKEEMLAELIKQRDIFLSLFDEKRHDHLVSTGQRRLSYKALQGALMIYFYREEPRFQVPFQLLTSLMDIDTLMTKWRYNHVCMVHRMIGSKDGTGGSSGYQYLRSTVSDRYKVFVDLFNLATFLIPRDWVPKLDPSEHTFLYMAECCDSSYCSSSDDSD