Protein
HTH-type transcriptional regulator TcmR
Organism
Streptomyces glaucescens
Function
Represses transcription of the divergently oriented tcmR and tcmA (tetracenomycin C resistance and export) genes by binding to an intergenic operator region. This binding is inhibited by tetracenomycin C.
Sequence
MDSAETDTPSTRSTPNGPGLRQRKLRRTRDQLIREALELFLAQGYEHTTVEQIAEAVEVHPRTFFRHFASKEEVALTPISAIDEAFLAALEVRPAGENPLQAMSGAFRAVLGRVRDGELEGVDGALHMAMMRLVERTPGLLAEYLRRSEEMEGRLARIIAAREGVDLDDDFRPRFIVAVFKAVGRVVSREWYLRADTDLEALSVAFESALDSLRPELFADWRRPGA