Protein
Membrane-associated protein TcaA
Organism
Staphylococcus aureus (strain COL)
Function
Plays a major role in decreasing resistance to glycopeptide antibiotics. Overexpression confers oxacillin hypersusceptibility, without affecting the levels of resistance towards vancomycin. Could be involved in virulence. Overexpression increases the levels of teicoplanin susceptibility. Overexpression also increased susceptibility to oxacillin in methicillin-resistant strains.
Similarity
Belongs to the TcaA family.
Sequence
MKSCPKCGQQAQDDVQICTQCGHKFDSRQAFYRKSTDEDIQTNNIKMRKMVPWAIGFFILILIIILFFLLRNFNSPEAQTKILVNAIENNDKQKVATLLSTKDNKVDSEEAKVYINYIKDEVGLKQFVSDLKNTVHKLNKSKTSVASYIQTRSGQNILRVSKNGTRYIFFDNMSFTAPTKQPIVKPKEKTKYEFKSGGKKKMVIAEANKVTPIGNFIPGTYRIPAMKSTENGDFAGHLKFDFRQSNSETVDVTEDFEEANISVTLKGDTKLNDSSKKVTINDHEMAFSSSKTYGPYPQNKDITISASGKAKDKTFTTQTKTIKASDLKYNTEITLNFDSEDIEDYVEKKEKEENSLKNKLIEFFAGYSLANNAAFNQSDFDFVSSYIKKGSSFYDDVKKRVSKGSLMMISSPQIIDAEKHGDKITATVRLINENGKQVDKEYELEQGSQDRLQLIKTSEK