Protein
E3 ubiquitin-protein ligase synoviolin B
Function
Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins. Protects cells from ER stress-induced apoptosis. Sequesters p53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis (By similarity).
Similarity
Belongs to the HRD1 family.
Sequence
MTGASLALTASVVAHAYYLKNQFYPTVVYLTKSSPSMAILYIQAFVLVFLLGKFMGKVFFGQLRAAEMEHLLERSWYAVTETCLAFTVFRDDFSPRFVALFTLLLFLKCFHWLAEDRVDFMERSPNISWLFHFRILALMLLLGVLDAFFVSHAYNSLVTRGASVQLVFGFEYAILMTMILAVFIKYILHSVDLQSENPWDNKAVYMLYTELFTGFIKVLLYMAFMTIMVKVHTFPLFAIRPMYLAMRQFKKAVTDAVMSRRAIRNMNTLYPDATAEELQAMDNVCIICREEMVSGAKRLPCNHIFHTSCLRSWFQRQQTCPTCRMDVLRASLPTQPQTPAEQQNQHQAQQQPTPVVPPQPNFPPGMLPPFPPGMFPLWPPMGQFPPVPGAPVGNPPDEANPGSSSGSSARAGETSNVGSESHPGAALPGFPFPPPFLGMSILPPFGLPPMPMPPAGFAGLTDEELRAMEGHERQNLEARLQCLQNIHTLLDAAMLQINQYLTVLASIGPPQPPVSSSSSSSASASTEPTTSSVSEPVIDTSSIVTTDSSQQSASPVPVNVETLGGAEGGETPTEEPDNVELRRRRLQKLETTDSQ