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syp1

Gene
SYP1
Protein
Suppressor of yeast profilin deletion
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
870 amino acids
Function
Multi-functional protein that contributes to the endocytic process, but also to events that occur at the neck during budding and/or cytokinesis. Plays a role as an endocytic adapters with membrane-tubulation activity that associates with transmembrane cargo proteins and initiates the formation of endocytic sites. Contributes to the stabilization of the nascent clathrin-coated pit. Plays also a role in late endocytosis by mediating vesiculation. Involved in the regulation of cell cycle-dependent dynamics of the septin cytoskeleton by promoting septin turnover in different cell cycle stages. May act through the RHO2 signaling pathway to repolarize cortical actin patches in profilin-deficient cells.
Similarity
Belongs to the SYP1 family.
Mass
96.137 kDa
Sequence
MTEQRTKYADSILTTKSPYEATETIRIRLSQVKLLNKDFYLLFKELANLKRNYAQQLRKIIAENEDITKILNAQMIESNVLTPQEMSAFRFNSLGELRNVWDTVIEELKSDLKSSTEYYNTLDQQVVRELKESVENNTSWRESKDLHSKLSKNAASIEHYSKNNENSSHLEEARRQWDQQSPYLFELFETIDYNRLDTLKNCMLRFQTSFSDYLLNTTKECETVMTKFLAFEPQSEIDRFAKDASQYNFQLSSSSKEVVPNNASPASATGARPVSVSNGAANTEREKKSPQKDKRKSAFGNIGHRLASASSSLTHNDLMNNEFSDSTNNSSLKSKKSSHTLRSKVGSIFGRNKTKNKRQQQSSSNSHIQASITETPNNSSTRVSSTATSSIYQKQRRPTYSSSKSNNWTPGEASDTPPLPPHATPKNVDAPVTADTPPAQTFTPSEVPPSTPQQSSPPTAKEPDSSNLPKTVPISISQPPLQPQSKTKPLPVEPASPSISLPTATVDNQPSGQVDSRPLHIRAPALPPSRKQNFIHNRDSQLYDSLPNHGSGATPTSSSLSSIPQERPVSTLSSQITGELRELNPQATGSSTSLVGQSLFQHSSLDTSQFGLNASIAEVLNASFKDGMLQNSQLIGEIALNYLPNSVMNSPLPIGINLRINNGAKFEKVILNQAFIERVAPEEFKVNPSFIDSRTLGAIKYSIKEPIAPIVIHPVWRFESHQASVVLTVKMSPSLPDEISQIVIEDLVVFVNIDGANATSALSKPQGSFSKEKKRITWRFKEPVVLTRNGEGQRLIARFITDGLAHESAKGVITKFTISETDNVALPHSGAGSGITLTCQELDENNPFGGEWLDVNTKRTLTTGNYHGLA

Gene
syp1
Protein
Cytoskeletal protein syp1
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
818 amino acids
Function
Multi-functional protein that contributes to the endocytic process, but also to events that occur at the neck during cytokinesis. Plays a role as an endocytic adapters with membrane-tubulation activity that associates with transmembrane cargo proteins and initiates the formation of endocytic sites. Contributes to the stabilization of the nascent clathrin-coated pit. Plays also a role in late endocytosis by mediating vesiculation. Involved in the regulation of cell cycle-dependent dynamics of the septin cytoskeleton by promoting septin turnover in different cell cycle stages (By similarity).
Similarity
Belongs to the SYP1 family.
Mass
90.757 kDa
Sequence
MESLTKTEYVDAFLSNYSPNDSMSIFRQRLEQVRLDNDMLSQWIRERMDIERQYSDQLHKLAMNMQEKNNSSFAFNYAWKQLEGETLEISRYHSQIIGQIASQVYKPLIDYYTSSPQTATLRRLAERLSTVAEEMASSSVPGLKGLKKKGRDADTKSQNDLTASRATWDSDAPLAFEKLQIVDEERLLILKQVYLTIASLETDTALKQQEFFSKSMAVYSDLPIEGEIRQFMNSTSKVMSSASANKPSKSSGFHINNGKSKEEKSHGENESGGKLKNKMSTLFRRKTIMPKKDKKPSHKSNGRPNKLTAFFNKNSKASSISSAEEHPSNIDDSSIERRHYDSNHSSQIRDHPSTNNNASSYQNFNETSDEGEDNDATIRANNVRSSFLEAPLPVQPNVQAETVTPKISSKASPFNKPNSVHSEASRNTPSSIDRENASHSNPIMMHGNDFGGNFNNMQSRSTTTSPTSAVASPAPTENEDSNAAIERVANTLRKNPTISRRTRRAGTMDRYATASSDYMESNLGSLPNLSTLSLQSGPDSTATWHPEFPNSSGLSASIVEKYSGELSEDGLLHPSCSGHIFMKYTSDFNTPPPEMGVRVASEFPMSFTHLNDHAVKYGPSENTLSLIPELLLSPIKVTDFNLHLDSINGASCIPLTVVQKWKHDESSSSMIAFVKPNPVWRNLGSSLHIEKLVIIVYLGENVLVKSCQSSPAGEFSRKTSKLKLHLSNINISSSGFKILAKFAISPSAAIRKPVIEFRIRMVDSSNNPGLTKLFLKPDMFDTTSSSGGSQLESAYEETKVPTSYGIHVRECSVFADMS