Protein
Serine/threonine/tyrosine-interacting protein B
Function
Probable pseudophosphatase. Contains a Gly residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase. The binding pocket is however sufficiently preserved to bind phosphorylated substrates, and may be protect them from phosphatases (By similarity).
Similarity
Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
Sequence
MEDVKLQFPSLPLCKEEAEDWTYPMRREMQEILPGLFLGPYSAAMKSKLSVLQKCGITHVICIRQNIEANFIKPNFQQLFRYLVLDIADNPVENIIRFFLTSKEFIDGCLQTGGKVLIHGNAGISRSAALVIAYIMETFGIKYRDAFTYVQERRFCINPNAGFVHQLQEYEAIYLAKLTIKMMSPLQLGRPLCIQSGSTGSLKRTLDDEDELGNMQVSAAHEG