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stxbp5l

Gene
STXBP5L
Protein
Syntaxin-binding protein 5-like
Organism
Homo sapiens
Length
1186 amino acids
Function
Plays a role in vesicle trafficking and exocytosis inhibition. In pancreatic beta-cells, inhibits insulin secretion probably by interacting with and regulating STX1A and STX4, key t-SNARE proteins involved in the fusion of insulin granules to the plasma membrane. Plays also a role in neurotransmitter release by inhibiting basal acetylcholine release from axon terminals and by preventing synaptic fatigue upon repetitive stimulation (By similarity). Promotes as well axonal outgrowth (PubMed:25504045).
Similarity
Belongs to the WD repeat L(2)GL family.
Mass
131.887 kDa
Sequence
MKKFNFRKVLDGLTASSPGSGSSSGSNSGGGAGSGSVHPAGTAGVLREEIQETLTSEYFQICKTVRHGFPHQPTALAFDPVQKILAIGTRTGAIRILGRPGVDCYCQHESGAAVLQLQFLINEGALVSASSDDTLHLWNLRQKRPAILHSLKFNRERITYCHLPFQSKWLYVGTERGNTHIVNIESFILSGYVIMWNKAIELSTKTHPGPVVHLSDSPRDEGKLLIGYENGTVVFWDLKSKRAELRVYYDEAIHSIDWHHEGKQFMCSHSDGSLTLWNLKSPSRPFQTTIPHGKSQREGRKSESCKPILKVEYKTCKNSEPFIIFSGGLSYDKACRRPSLTIMHGKAITVLEMDHPIVEFLTLCETPYPNEFQEPYAVVVLLEKDLIVVDLTQSNFPIFENPYPMDIHESPVTCTAYFADCPPDLILVLYSIGVKHKKQGYSNKEWPISGGAWNLGAQTYPEIIITGHADGSIKFWDASAITLQMLYKLKTSKVFEKQKVGEGKQTCEIVEEDPFAIQMIYWCPESRIFCVSGVSAYVIIYKFSRHEITTEIVSLEVRLQYDVEDIITPEPETSPPFPDLSAQLPSSRSLSGSTNTVASEGVTKDSIPCLNVKTRPVRMPPGYQAELVIQLVWVDGEPPQQITSLAVSSAYGIVAFGNCNGLAVVDFIQKTVLLSMGTIDLYRSSDLYQRQPRSPRKNKQFIADNFCMRGLSNFYPDLTKRIRTSYQSLTELNDSPVPLELERCKSPTSDHVNGHCTSPTSQSCSSGKRLSSADVSKVNRWGPGRPPFRKAQSAACMEISLPVTTEENRENSYNRSRSSSISSIDKDSKEAITALYFMDSFARKNDSTISPCLFVGTSLGMVLIISLNLPLADEQRFTEPVMVLPSGTFLSLKGAVLTFSCMDRMGGLMQPPYEVWRDPNNIDENEKSWRRKVVMNSSSASQEIGDHQYTIICSEKQAKVFSLPSQTCLYVHNITETSFILQANVVVMCSSACLACFCANGHIMIMSLPSLRPMLDVNYLPLTDMRIARTFCFTNEGQALYLVSPTEIQRLTYSQEMCDNLQDMLGDLFTPIETPEAQNRGFLKGLFGGSGQTFDREELFGEASAGKASRSLAQHIPGPGSIEGMKGAAGGVMGELTRARIALDERGQRLGELEEKTAGMMTSAEAFSKHAHELMLKYKDKKWYQF

Gene
Stxbp5l
Protein
Syntaxin-binding protein 5-like
Organism
Mus musculus
Length
1185 amino acids
Function
Plays a role in vesicle trafficking and exocytosis inhibition (PubMed:25002582). In pancreatic beta-cells, inhibits insulin secretion probably by interacting with and regulating STX1A and STX4, key t-SNARE proteins involved in the fusion of insulin granules to the plasma membrane (PubMed:21998599). Plays also a role in neurotransmitter release by inhibiting basal acetylcholine release from axon terminals and by preventing synaptic fatigue upon repetitive stimulation (PubMed:24744148). Promotes as well axonal outgrowth (By similarity).
Similarity
Belongs to the WD repeat L(2)GL family.
Mass
131.844 kDa
Sequence
MKKFNFRKVLDGLTASSPGSGSSSGSNSGGAGSGSVHPGGTAGLPREEIQESLTSDYFQICKTVRHGFPYQPTALAFDPVQKILAIGTRTGAIRILGRPGVDCYCQHESGAAVLQLQFLINEGALVSASSDDTLHLWNLRQKRPAILHSLKFNRERITYCHLPFQSKWLYVGTERGNTHIVNIESFILSGYVIMWNKAIELSTKTHPGPVVHLSDSPRDEGKLLIGYENGTVVFWDLKSKRAELRVYYDEAIHSIDWHHEGKQFMCSHSDGSLTLWNLKSPSRPFQTTVPHGKSQREGRKSESCKPILKVEYKTCRNSEPFIIFSGGLSYDKACRRPSLTIMHGKAITVLEMDHPIVEFLTLCETPYPNEFQEPYAVAVLLEKDLIVVDLTQTNFPIFENPYPMDIHESPVTCTAYFADCPPDLILVLYSIGVKHKKQGYSNKEWPVSGGAWNLGAQTYPEIIITGHADGTIKFWDASAMTLQMLYKLKTSKVFEKQKAGEGKQTCELVEEDPFAVQMIYWCPESRIFCVSGVSAYVIIYKFSRHEVTTEIVSLEVRLQCDVEDIITPEPETSPPFPDLSSQLPPSRSLSGSTNTVSSEGVTKDSIPCLSVKTRPVRMPPGYQADLVIQLVWVDGEPPQQITSLSISSAYGIVAFGNCTGLVVVDFIQKTVLLSMGTIDLYRSSDLYQRQPRSPRKNRQFIADNFCMRGLSNFYPDLTKRIRTSYQSLTELNDSPVPLELERCKSPTSDHVNGHCTSPTSQSCSSGKRLSSADVSKVNRWGPGRPPFRKAQSAACMEISLPVTTEETRENSYNRSRSSSISSIDKDSKEAITALYFMESFARKNDSTVSPCLFVGTSLGMVVLISLNLPSSDEQRFTEPVVVLPSGTFLSLKGAVLTFSCMDRTGSLMQPPYEVWRDPNNTDENEKTWKRKLVMNYSSSSQEMGDHQYTIICSEKQAKVFSLPSQTCLYVHNITETSFILQADVVVMCNSACLACFCANGHIMIMSLPSLRPMLDVNYLPLTDMRIARTFCFTNEGQALYLVSPTEIQRLTYSQEMCDNIQDMLGDLFTPIETPEAQNRGFLKGLFGGSGQTFDREELFGEASAGKASRSLAQHIPGPGSIEGMKGAAGGVMGELTRARIALDERGQRLGELEEKTAGMMTSAEAFSKHAHELMLKYKDKKWYQF

Gene
stxbp5l
Protein
Syntaxin-binding protein 5-like
Organism
Danio rerio
Length
1159 amino acids
Function
May play a role in vesicle trafficking and exocytosis.
Similarity
Belongs to the WD repeat L(2)GL family.
Mass
128.203 kDa
Sequence
MKKFRKVLDGLTTSSPVNPGGSPGCGSAAGTPSAAPTPRELEIQETLMSEHFQICKTVRHGFPYQPTALAFDPVQKILAIGSRSGGIRMYPFLSFPHLGRPGVDCHSQHESGAAVLQMQFLINEGALVTACADDTLHLWSLRQRLPAILHSLKFNRERITFCHLPFQSKWLYVGTERGNTHIVNIESFILSGYVIMWNKAIELSTKTHPGPVVHLSDSPKDEGKLLIGFESGTIVMWDLRAKRADFRIYYDEAIHSVSWHHEGRQFMCSHSDGSLSMWNMRNTAKPFQVTFPHGKTQRDGRKESCKPILKVEYKTSRNSSEAFVIFSGGLSYDKAGRRPTLTIMHGKAITVLEMDYPIVDFMVLCETPYLNEVQEPYAVVVLLEKDFVVVDLTQSNFPIFENPYPMDVHESPVTCTAYFADCPPDIIPVLYSIGAKHKKTGYSHKEWPVSGGTWTVGSQTYPEIIITGHADGSIKFWDATAITLQMLYKLKTSKVFEKPKTGDMGRSADLVEEDPYAVQMISWCPQSRIFCVVGISAHVILYRFSKHDANTIITSLELRLQCEMEDVISPSDTENTPCFSDPSGHSPQPQPPSPRSNTPDSVRDSIPCLKVKDRMIRMPPGYQAELVVQLLWVDGEPPQQITCLDLNSAYGLLALGNCNGLAVVDYLQKTILLCMSTLELYGSADPFQRLTRSPRKNRQSTSGLTELSDNQVSLDLERSKSPTSDHVNGHCTSPTSQPCPSGRARVPGGPEGPRLARRGPGRPPFRKAQSAACMEVSLPVSSLTEENSFSRSRSSSVSSIDRETKEAVTTLQFAESYGRKSDSLPTPCLWVGTSLGLVLIIPMSIPTDEQERQEDPVTVAPTGTVLMLKGSVLRFGFLDCGGALINSPYEVWRDQHAPDDPDRPRKRKLVNFSPSSSQEACGDGHLAVVCSERQAKVFYMPSQACLYVHNITESSFVLRADVVSVSNSVCLACFCANGHIMILSLPSLRPLLDVSYLPLTDMRIARTFCFTNGGQALYLCSPTEIQRITYSQEMCETLGELFTPIETPEAQNRGFLKGFFGGNAQTFDREELFGEASAGKASRSLAQHIPGQGGIEGMKAAAGGVVGDLARARIALDERGQRLGELEERTALMMTSAETFSKHAHELMLKCKDKKWYQF