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sttH

Gene
sttH
Protein
Streptothricin hydrolase
Organism
Streptomyces albulus
Length
276 amino acids
Function
Catalyzes the hydrolysis of the amide bond of streptolidine lactam, thereby conferring streptothricin (ST) resistance. Can hydrolyze streptothricin-F and streptothricin-D. However, this strain is believed to be a ST nonproducer, which raises the possibility that its true role may not be its involvement in self-resistance to STs. May catalyze the hydrolysis of naturally occurring cyclic amide compounds that are structurally related to STs.
Similarity
Belongs to the isochorismatase family.
Mass
28.255 kDa
Sequence
MIRPDRCPWQPCPSGRYLSRPSGRVPRSTMMTPMTAMPAVTAMPPETAAPPETAAPARPLRPVQALLVVDVQTAFVSGAEAVPEAARVLDRTRGLLARARTAGALVVHLQNDGAPGAVDAPHTPGWELHLPVEPGPREHVVRKTEDDGFADTGLGALLDAAGVTELAVCGVLSEMCVAATARTALELGHRVVLPHDAHATYDIPAAPDISDTVPAAMSSRAAEWALGDEVEIVPRAAAVPFVAPPLAPAPEAPAAAAAPAAGTGLSPAGPPPAPAR

Gene
sttH
Protein
Streptothricin hydrolase
Organism
Streptomyces noursei
Length
252 amino acids
Function
Catalyzes the hydrolysis of the amide bond of streptolidine lactam, thereby conferring streptothricin (ST) resistance. Can hydrolyze streptothricin-F and streptothricin-D. However, this strain is believed to be a ST nonproducer, which raises the possibility that its true role may not be its involvement in self-resistance to STs. May catalyze the hydrolysis of naturally occurring cyclic amide compounds that are structurally related to STs.
Similarity
Belongs to the isochorismatase family.
Mass
26.136 kDa
Sequence
MIRPGRCLWQPCLSGRKRSRPSGPVSRHGMMAAMTAPTAAAIRPVQALLVVDVQAAFVSGWEAVPDADRVLRCTRDLLSRARAAGALVVHLQNDGEPGAVDAPHTPGWELHLPVEPGPRERVVRKTEDDGFADTPLGDLLTDAGVTELAVCGVLSEMCVAATARTALVRGHRVVLPHDAHATYDIPAAPGISDTVPAAMSSRAAEWALGDEVEIVPHAAAVPFAAAPRPAVGPAAAPGLPVSPAAPPPSPVR