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stt3

Gene
stt3
Protein
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit stt3
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
752 amino acids
Function
Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets.
Similarity
Belongs to the STT3 family.
Mass
84.974 kDa
Sequence
MANSATITSKKGVKSHQKDWKIPLKVLILICIAVASVSSRLFSVIRYESIIHEFDPWFNFRASKILVEQGFYNFLNWFDERSWYPLGRVAGGTLYPGLMVTSGIIFKVLHLLRINVNIRDVCVLLAPAFSGITAIATYYLARELKSDACGLLAAAFMGIAPGYTSRSVAGSYDNEAIAITLLMSTFALWIKAVKSGSSFWGACTGLLYFYMVTAWGGYVFITNMIPLHVFVLLLMGRYTSKLYIAYTTYYVIGTLASMQVPFVGFQPVSTSEHMSALGVFGLLQLFAFYNYVKGLVSSKQFQILIRFALVCLVGLATVVLFALSSTGVIAPWTGRFYSLWDTNYAKIHIPIIASVSEHQPPTWSSLFFDLQFLIWLLPVGVYLCFKELRNEHVFIIIYSVLGTYFCGVMVRLVLTLTPCVCIAAAVAISTLLDTYMGPEVEEDKVSEEAASAKSKNKKGIFSILSFFTSGSKNIGIYSLLSRVLVISSTAYFLIMFVYHSSWVTSNAYSSPTVVLSTVLNDGSLMYIDDFREAYDWLRRNTPYDTKVMSWWDYGYQIAGMADRITLVDNNTWNNTHIATVGKAMSSPEEKAYPILRKHDVDYILIIYGGTLGYSSDDMNKFLWMIRISQGLWPDEIVERNFFTPNGEYRTDDAATPTMRESLLYKMSYHGAWKLFPPNQGYDRARNQKLPSKDPQLFTIEEAFTTVHHLVRLYKVKKPDTLGRDLKQVTLFEEGKRKKLRRPAKTNEIPLRV

Gene
STT3
Protein
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
718 amino acids
Function
Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (PubMed:12359722). This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets (PubMed:29301962).
Similarity
Belongs to the STT3 family.
Mass
81.529 kDa
Sequence
MGSDRSCVLSVFQTILKLVIFVAIFGAAISSRLFAVIKFESIIHEFDPWFNYRATKYLVNNSFYKFLNWFDDRTWYPLGRVTGGTLYPGLMTTSAFIWHALRNWLGLPIDIRNVCVLFAPLFSGVTAWATYEFTKEIKDASAGLLAAGFIAIVPGYISRSVAGSYDNEAIAITLLMVTFMFWIKAQKTGSIMHATCAALFYFYMVSAWGGYVFITNLIPLHVFLLILMGRYSSKLYSAYTTWYAIGTVASMQIPFVGFLPIRSNDHMAALGVFGLIQIVAFGDFVKGQISTAKFKVIMMVSLFLILVLGVVGLSALTYMGLIAPWTGRFYSLWDTNYAKIHIPIIASVSEHQPVSWPAFFFDTHFLIWLFPAGVFLLFLDLKDEHVFVIAYSVLCSYFAGVMVRLMLTLTPVICVSAAVALSKIFDIYLDFKTSDRKYAIKPAALLAKLIVSGSFIFYLYLFVFHSTWVTRTAYSSPSVVLPSQTPDGKLALIDDFREAYYWLRMNSDEDSKVAAWWDYGYQIGGMADRTTLVDNNTWNNTHIAIVGKAMASPEEKSYEILKEHDVDYVLVIFGGLIGFGGDDINKFLWMIRISEGIWPEEIKERDFYTAEGEYRVDARASETMRNSLLYKMSYKDFPQLFNGGQATDRVRQQMITPLDVPPLDYFDEVFTSENWMVRIYQLKKDDAQGRTLRDVGELTRSSTKTRRSIKRPELGLRV

Gene
stt3
Protein
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3
Organism
Dictyostelium discoideum
Length
714 amino acids
Function
Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets.
Similarity
Belongs to the STT3 family.
Mass
80.546 kDa
Sequence
MKRSEKSSTSVVSNNKQQDVNIISSNEVGVKEENKGHQEFLLKVLILSVIYVLAFSTRLFSVLRYESVIHEFDPYFNYRSTIYLVQEGFYNFLNWFDERAWYPLGRIVGGTIYPGLMATASLVHWSLNSLNITVNIRNVCVLLSPWFASNTAMVTYKFAKEVKDTQTGLVAAAMIAIVPGYISRSVAGSFDNEGIAIFALIFTYYCWIKSVNTGSLMWAAICSLAYFYMASAWGGYVFIINLIPLHAFFLLLTGRYSHRLYIAYSTMFVIGTILSMQITFISFQPVQSSEHLAAIGIFGLLQLYAGLSWVKSHLTNEAFKKLQRLTVLFVLSCAAAVLVVGTLTGYISPFNGRFYSLLDPTYARDHIPIIASVSEHQPTTWASYFFDLHILVFLFPAGLYFCFQKLTDANIFLILYGVTSIYFSGVMVRLMLVLAPVACILAAVAVSATLTTYMKKLKAPSSPSDANNSKESGGVMVAVLTVLLILYAFHCTWVTSEAYSSPSIVLSAKQNDGSRVIFDDFREAYRWIGQNTADDARIMSWWDYGYQLSAMANRTVLVDNNTWNNSHIAQVGKAFASTEEDAYIQMKALDVDYVLVIFGGLTGYSSDDINKFLWMVRIGGSCDPNIKEQDYLTNGQYRIDKGASPTMLNSLMYKLSYYRFSEVHTDYQRPTGFDRVRNVEIGNKNFDLTYLEEAFTSVHWLVRVYKVKDFDNRA