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strd-1

Gene
strd-1
Protein
STE20-related kinase adapter protein strd-1
Organism
Caenorhabditis elegans
Length
388 amino acids
Function
Pseudokinase which may act as an adapter for kinases sad-1 and par-4 and thereby is involved in several developmental processes. Regulates cell-autonomously both neuronal polarity and synaptic organization when bound to sad-1. Required for sad-1 localization to synapses (PubMed:20023164). Required to establish germline stem cell (GSC) quiescence during dauer development, to promote cell shedding during embryogenesis and to control asymmetric cell division of the Q.p neuroblast lineage, probably when bound to par-4 (PubMed:20110331, PubMed:22801495, PubMed:23267054). May be involved in maintaining the integrity of the early embryonic cortex when bound to par-4 (PubMed:20110331).
Similarity
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Mass
44.275 kDa
Sequence
MADTTILDTTCSSTLAANVEFSHATDSAIGISLKNATITEAEGVPNLKETGYDCVRYMGTCNGGQIYLGRERKKLKDYVAIKKFAIDDVDDYAAIAKESSNLRLMHHPNIIELCECFVYERSIYQITPAMNLGSLFDIVFEYMKWGINEKSAAAITRQLLDALSYLHQRRYIHRDLKPKHILIDSSGNVKLSGFRFMIELNHHLDCVFEFDAHLQNQLYYLAPEVLAQNIHGYTSKSDIYMLGISICEAINGVMPFGELEPLEMLHRKLNGQVPRPVDMISLKDDQKMGLDISHRPQEHLTRRFSKEMHEFIANCLDYDPQQRGSASDLKSSAWLGSKIHKNLGPVDVRQELNLDYAHFDLSLWEQEPLIPMEPDQKYEIVFDYSPIS