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strat

Gene
strat
Protein
Guanine nucleotide exchange factor MSS4 homolog
Organism
Drosophila melanogaster
Length
122 amino acids
Function
Guanine-nucleotide-releasing protein that acts on members of the sec4/ypt1/rab subfamily such as Rab8. During egg development, essential for establishing and maintaining epithelial cell polarity by regulating the correct polarized deposition of basal membrane (BM) proteins such as trol/Pcan and vkg/Coll IV to the basal surface of follicular epithelial (FE) cells. Likely to function by restricting the activity of the vesicle transport regulator Rab8 to the basal membrane, and thus directs BM protein-containing vesicles to the basal side of the FE cells. This function is independent of the Crag/Rab10 regulation of polarized BM protein secretion in the FE.
Similarity
Belongs to the DSS4/MSS4 family.
Mass
14.021 kDa
Sequence
MTEEADFSEQITDGKNKSNVRCQFCNCLMLKAQEGTYNQEEVDVPLMTQKQDRTADSLNSEPLKDFWLVKDMMTFENIGFSNTVDGRKFLVCADCERGPVGYHDLSTRHCYLALKRVVHKDT