Protein
dTDP-glucose 4,6-dehydratase
Organism
Streptomyces griseus
Function
Involved in the biosynthesis of the streptose moiety of streptomycin (PubMed:1661369). Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction (By similarity).
Similarity
Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.
Sequence
MTTHLLVTGAAGFIGSQYVRTLLGPGGPPDVVVTALDALTYAGNPDNLAAVRGHPRYRFERGDICDAPGRRVMAGQDQVVHLAAESHVDRSLLDASVFVRTNVHGTQTLLDAATRHGVASFVQVSTDEVYGSLEHGSWTEDEPLRPNSPYSASKASGDLLALAHHVSHGLDVRVTRCSNNYGPRQFPEKLIPRFITLLMDGHRVPLYGDGLNVREWLHVDDHVRGIEAVRTRGRAGRVYNIGGGATLSNKELVGLLLEAAGADWGSVEYVEDRKGHDRRYAVDSTRIQRELGFAPAVDLADGLAATVAWYHKHRSWWEPLVPAGSLPA