Protein
Probable polyketide synthase 1
Organism
Dictyostelium discoideum
Function
Probable polyketide synthase (By similarity). Produces only acylpyrones; in vitro.
Similarity
In the C-terminal section; belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.
Sequence
MNKNSKIQSPNSSDVAVIGVGFRFPGNSNDPESLWNNLLDGFDAITQVPKERWATSFREMGLIKNKFGGFLKDSEWKNFDPLFFGIGPKEAPFIDPQQRLLLSIVWESLEDAYIRPDELRGSNTGVFIGVSNNDYTKLGFQDNYSISPYTMTGSNSSLNSNRISYCFDFRGPSITVDTACSSSLVSVNLGVQSIQMGECKIAICGGVNALFDPSTSVAFSKLGVLSENGRCNSFSDQASGYVRSEGAGVVVLKSLEQAKLDGDRIYGVIKGVSSNEDGASNGDKNSLTTPSCEAQSINISKAMEKASLSPSDIYYIEAHGTGTPVGDPIEVKALSKIFSNSNNNQLNNFSTDGNDNDDDDDDNTSPEPLLIGSFKSNIGHLESAAGIASLIKCCLMLKNRMLVPSINCSNLNPSIPFDQYNISVIREIRQFPTDKLVNIGINSFGFGGSNCHLIIQEYNNNFKNNSTICNNNNNNNNNIDYLIPISSKTKKSLDKYLILIKTNSNYHKDISFDDFVKFQIKSKQYNLSNRMTTIANDWNSFIKGSNEFHNLIESKDGEGGSSSSNRGIDSANQINTTTTSTINDIEPLLVFVFCGQGPQWNGMIKTLYNSENVFKNTVDHVDSILYKYFGYSILNVLSKIDDNDDSINHPIVAQPSLFLLQIGLVELFKYWGIYPSISVGHSFGEVSSYYLSGIISLETACKIVYVRSSNQNKTMGSGKMLVVSMGFKQWNDQFSAEWSDIEIACYNAPDSIVVTGNEERLKELSIKLSDESNQIFNTFLRSPCSFHSSHQEVIKGSMFEELSNLQSTGETEIPLFSTVTGRQVLSGHVTAQHIYDNVREPVLFQKTIESITSYIKSHYPSNQKVIYVEIAPHPTLFSLIKKSIPSSNKNSSSVLCPLNRKENSNNSYKKFVSQLYFNGVNVDFNFQLNSICDNVNNDHHLNNVKQNSFKETTNSLPRYQWEQDEYWSEPLISRKNRLEGPTTSLLGHRIIYSFPVFQSVLDLQSDNYKYLLDHLVNGKPVFPGAGYLDIIIEFFDYQKQQLNSSDSSNSYIINVDKIQFLNPIHLTENKLQTLQSSFEPIVTKKSAFSVNFFIKDTVEDQSKVKSMSDETWTNTCKATISLEQQQPSPSSTLTLSKKQDLQILRNRCDISKLDKFELYDKISKNLGLQYNSLFQVVDTIETGKDCSFATLSLPEDTLFTTILNPCLLDNCFHGLLTLINEKGSFVVESISSVSIYLENIGSFNQTSVGNVQFYLYTTISKATSFSSEGTCKLFTKDGSLILSIGKFIIKSTNPKSTKTNETIESPLDETFSIEWQSKDSPIPTPQQIQQQSPLNSNPSFIRSTILKDIQFEQYCSSIIHKELINHEKYKNQQSFDINSLENHLNDDQLMESLSISKEYLRFFTRIISIIKQYPKILNEKELKELKEIIELKYPSEVQLLEFEVIEKVSMIIPKLLFENDKQSSMTLFQDNLLTRFYSNSNSTRFYLERVSEMVLESIRPIVREKRVFRILEIGAGTGSLSNVVLTKLNTYLSTLNSNGGSGYNIIIEYTFTDISANFIIGEIQETMCNLYPNVTFKFSVLDLEKEIINSSDFLMGDYDIVLMAYVIHAVSNIKFSIEQLYKLLSPRGWLLCIEPKSNVVFSDLVFGCFNQWWNYYDDIRTTHCSLSESQWNQLLLNQSLNNESSSSSNCYGGFSNVSFIGGEKDVDSHSFILHCQKESISQMKLATTINNGLSSGSIVIVLNSQQLTNMKSYPKVIEYIQEATSLCKTIEIIDSKDVLNSTNSVLEKIQKSLLVFCLLGYDLLENNYQEQSFEYVKLLNLISTTASSSNDKKPPKVLLITKQSERISRSFYSRSLIGISRTSMNEYPNLSITSIDLDTNDYSLQSLLKPIFSNSKFSDNEFIFKKGLMFVSRIFKNKQLLESSNAFETDSSNLYCKASSDLSYKYAIKQSMLTENQIEIKVECVGINFKDNLFYKGLLPQEIFRMGDIYNPPYGLECSGVITRIGSNVTEYSVGQNVFGFARHSLGSHVVTNKDLVILKPDTISFSEAASIPVVYCTAWYSLFNIGQLSNEESILIHSATGGVGLASLNLLKMKNQQQQPLTNVYATVGSNEKKKFLIDNFNNLFKEDGENIFSTRDKEYSNQLESKIDVILNTLSGEFVESNFKSLRSFGRLIDLSATHVYANQQIGLGNFKFDHLYSAVDLERLIDEKPKLLQSILQRITNSIVNGSLEKIPITIFPSTETKDAIELLSKRSHIGKVVVDCTDISKCNPVGDVITNFSMRLPKPNYQLNLNSTLLITGQSGLSIPLLNWLLSKSGGNVKNVVIISKSTMKWKLQTMISHFVSGFGIHFNYVQVDISNYDALSEAIKQLPSDLPPITSVFHLAAIYNDVPMDQVTMSTVESVHNPKVLGAVNLHRISVSFGWKLNHFVLFSSITAITGYPDQSIYNSANSILDALSNFRRFMGLPSFSINLGPMKDEGKVSTNKSIKKLFKSRGLPSLSLNKLFGLLEVVINNPSNHVIPSQLICSPIDFKTYIESFSTMRPKLLHLQPTISKQQSSIINDSTKASSNISLQDKITSKVSDLLSIPISKINFDHPLKHYGLDSLLTVQFKSWIDKEFEKNLFTHIQLATISINSFLEKVNGLSTNNNNNNNSNVKSSPSIVKEEIVTLDKDQQPLLLKEHQHIIISPDIRINKPKRESLIRTPILNKFNQITESIITPSTPSLSQSDVLKTPPIKSLNNTKNSSLINTPPIQSVQQHQKQQQKVQVIQQQQQPLSRLSYKSNNNSFVLGIGISVPGEPISQQSLKDSISNDFSDKAETNEKVKRIFEQSQIKTRHLVRDYTKPENSIKFRHLETITDVNNQFKKVVPDLAQQACLRALKDWGGDKGDITHIVSVTSTGIIIPDVNFKLIDLLGLNKDVERVSLNLMGCLAGLSSLRTAASLAKASPRNRILVVCTEVCSLHFSNTDGGDQMVASSIFADGSAAYIIGCNPRIEETPLYEVMCSINRSFPNTENAMVWDLEKEGWNLGLDASIPIVIGSGIEAFVDTLLDKAKLQTSTAISAKDCEFLIHTGGKSILMNIENSLGIDPKQTKNTWDVYHAYGNMSSASVIFVMDHARKSKSLPTYSISLAFGPGLAFEGCFLKNVV