Protein
PAPS-dependent sulfotransferase Stf3
Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Function
Required for the sulfation of S881. S881 is a sulfated menaquinone, which is localized in the outer envelope of M.tuberculosis and negatively regulates its virulence. 3'-phosphoadenosine-5'-phosphosulfate (PAPS) is the sulfate donor.
Similarity
Belongs to the Stf3 family.
Sequence
MKALRSSSRLSRWREWAAPLWVGCNFSAWMRLLIRNRFAVHHSRWHFAVLYTFLSMVNSCLGLWQKIVFGRRVAETVIADPPIFIVGHWRTGTTLLHELLVVDDRHTGPTGYECLAPHHFLLTEWFAPYVEFLVSKHRAMDNMDLSLHHPQEDEFVWCMQGLPSPYLTIAFPNRPPQYEEYLDLEQVAPRELEIWKRTLFRFVQQVYFRRRKTVILKNPTHSFRIKVLLEVFPQAKFIHIVRDPYVVYPSTIHLHKALYRIHGLQQPTFDGLDDKVVSTYVDLYRKLDEGRELVDPTRFYELRYEDLIGDPEGQLRRLYQHLGLGDFECYLPRLRQYLADHADYKTNSYQLTVEQRAIVDEHWGEIIDRYGYDRHTPEPARLRPAVGG