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ssx2ip-b

Gene
ssx2ip-b
Protein
Afadin- and alpha-actinin-binding protein B
Organism
Xenopus laevis
Length
545 amino acids
Function
Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Involved in cell movement. Acts as a centrosome maturation factor, probably by maintaining the integrity of the pericentriolar material and proper microtubule nucleation at mitotic spindle poles. The function seems to implicate at least in part WRAP73; the SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome (By similarity).
Similarity
Belongs to the ADIP family.
Mass
63.836 kDa
Sequence
MGDWRTISLPESDKILQYSSEIRMSPTSLLSSPSHSAANTLSGIVYNFCTEDNIEQCITYIDQELRTIGFPTVQAVSKNGDGRKLHLVSIVNCIHELLQRNSQNMRSKEEVETQLLKINGDLEHLQSIYQRQKDQMEATRRENCALQERDRQMQCKNRNLLQLLKNEKEEVQKLQNIIASRSTQFNHSVKRKEREYNKLKERLYQLVMDKRDKKISIDVLNYVGRADGKRTSWRTGKTDAKNEEEMYKVLLNDYEQRQKQLMVENAELKKVLQQMKKEMISILSQRKTKEKLDDSIGPVASDIEEDLADSSKENLSELSCEAVREQLVSSIRQQWRILKSHMEKLDNQATPDENGMIARGDHEQELGKLINEIQQCKETIKIQQQLLKQQFSVPRDDTSTLLQDCYLLEDKERLQEEWKLFNEQKKNFEKERRNFTEAAIRLGHEKKAFEEDRAAWLKHQFLNMTVFTDHKNSEEKRAHGVHFSPEQDHCRLHSRTHDRHLASSGDHYQRPRKTLPITPSSKHSLTQRESVAWRDSSISPNGTDF