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srb8

Gene
SRB8
Protein
Mediator of RNA polymerase II transcription subunit 12
Organism
Ustilago maydis (strain 521 / FGSC 9021)
Length
1876 amino acids
Function
Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex (By similarity).
Similarity
Belongs to the Mediator complex subunit 12 family.
Mass
204.266 kDa
Sequence
MLRSGAASASSGGGRGPSSSLSSVKRSKHDDTRLPEAYQQERPPWRPPLHPTAARRHVPDLFPTKSGQPEDDMSQISVRKGFAPRTYVHNEYFCAHDAIHTRLLSPDALDTLSDWMDEVMQRRRELDRASIATNQYKPPSRVTLNDAKLANYVKDLADPTVPLMRLSRSVPHGFRGEKLFEMLWVGGALPSTATAATTTVNYFHSRIAGPPSASSASASASASASTSAPRKSVDIPRAVWFIRALGAAELSSLRNKSAATIIPEITSNLCAWMAKQVAELNLVHTAESNSTATASPAPVSPSTHLPRTPSAAPSSLSRSVAAAHFARTPSNLNPASSPSLAPAKEVCYVLQNDADEERWIAKWSYSLSLARHLHAQNLLDRSVLVRWIVDAFSASNLVQLPFLLELVQEVLLLVLRRRCFVKPFLTALLVQIPNVDARLDPSSSGGLRTKLVLLFRIVCENSPESLISPRLWFEHSASLTQLLNELNAETPLPLSHQAFEFVEQTVRPRVDRLLLRPHSGNTTQNASLETQETLSSPLQHHLDIQALDSFDMTTIDRVFLQNTSATHRYAKHDRDDTVWATRIDTILTWACTDRRSGVVRQYLAATLIEKIRFGVPWEESSEETDQVSLPAFDLEHNTTKTRKINVEPMLIKWLGDVETSLNQKLDESSTQTRVSLLATVDVGAIVVLLGELARRGVFSYTKYLQRLIARGMTAPSASSATEQHQNPDGSVQTPSSVSASRDSLHLRLLRSLPLYDQPASVYQQRRQAIYGDRTKETYEDAAQRRALRQLQSFLPFAFAQEVQAEASRIAVSPSPSTPDPVHALSRLWSASRFVRCRLFRSELLPAVTARVERLNGDQLSQISAVLVMADDFEGLAQLLATLLLRPLSDNLARAAFNMVIEYSLVWRSMDIMATLNQLVRQQLNHSSSIRNDRQAVMASTTLLRLRTLIENVPSRISASALDPGADHDALQQHVQALRPNVDALLDRFAKLTRSSVESDGSIASSSTPVEGSDMLTPFRSLFVQPDAMSDEMIERTIVDSVFARSDTSLVPSAVRLIDQLYLEASLEIDERHARWLSNLVLSIEQGTHSDASMKALLSLLTRLIAHGTLNLQLAMDTFLLPYLLSSVRRLTDPATRNTEVPMHIGSIVSSLGEIFASSLGETVPATSYEDMRAFGAQTKLLFAQVNLPSLLRAATCLISAFDETSTVPASEKAQIESFCNALLQSQPMQIAFRQEPRLCILAIKDTCKSMWGCNPSRVIDLAMACLDPTSLLLRDVGTIDAASVKNRLDGWDTAVVATELVEIFERLQLVESSFQTRADSKTKALASGIFDDLFVQLPDIGAQLVRDCQSSGLVSRFTDIGIKILSDKVKAASTDADKTPRRMDNSHKGMTNFGPDDGADAPAQAKTAADAAKHGPCVGEQQVESTLRSVVRMCEQQHSFIFNATDADSCAQLLLHVVTSLEDALGSMAAASHQDKVARLVTVLHGSMTFQLMHLVLRFGCLWNGTMRALALRLVKALLELTRQAGEKTECGGSFALLLDSLSFVLDELPPTLLSTCLPELETQLQTIELATQERSDKLQQLSFRLDNATTANAWLVASSAGAALKKGWFTSGGLNPWECAEYLEAPPAANPAAAGAAGAAGAAAGGNARAGVVETGRSGVNSRAAVESPGAVTVNDAETCNSLPGARTGWTGKLWLNTAIPLSMLGVRVTRDLVPNYASPASPGGVSVGSNDASSQPWTTGGGASAIGVGTCSAMDMDAKEALAALPMFVESERTYGERSAGEPAYSRDLRRGLLVEPNLPCRTRDERGETSQEPARATMDPAGAHTSVTSSATHDPSHVIDLTWDADEEMPLSTHPHHPAVATTSRKRRLSKRD

Gene
srb8
Protein
Mediator of RNA polymerase II transcription subunit 12
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Length
1789 amino acids
Function
Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex (By similarity).
Similarity
Belongs to the Mediator complex subunit 12 family.
Mass
198.74 kDa
Sequence
MTSRPPLGVQQRQPQQRKLSGPVLSQQRSLSQSQAQAQAQAQQQQQQQQQQQQQQQQQQQQQQQQQYDASSYLPPPPPVPTRNNNHNNFSNPNNTLNNAFPPELAQQDPTSIVSPADPSGSSPALSVGVGRYGTQRRGGSRLRLELSHNDPFDAFSSPTVIESPGLVEPHTQNGSLTHPMMPLADGPDLGDMSPHHRVSIPPQHLDADVPIPFPQRRPKAVPDHSRREQPPPPPNPARKDTRPKPYTIELPAAAPRYRIRGRSDGQGGQGRSSALATASSSSTTGSSATANYGCADFFPWSGTAGNHPEDQFNDTAIRVGYSEKQFVTPETQSAKTVLFHGLKQRSGLNALSIFFAGVLWHRRNAGQVTAPSTFKPPPRVTLTDTKKEVWLKDLANSAIPLRKLSRSIPHGVRNKVLLDQCLNKNVPIDRAVWLAKCVGTNELRTFRRLGKGNNASVLEGERKWLKDWTLVIENFIERVFFSFGEQNWKAKVNYAIQLAAHLYAEGLMDREHYLDWTVSSLESSHHSQLPMWIIIAQIYWKDLLRLRKYGRRLATALISHYHVIHAHEDRDIYVPLLSKLSHLLGTLMVATPENFVSPSVWVKYRDALKTCLPQGDEARHRSFAGINYRNEQLVASANRSQPAARIILVRNLDQVILEKPMPDEFPAQCWTVSKDKAALVRALLEWCTTPYRPGLAKVYVAHRILMHWSTLRLDVTSAVLGFMEGEALEEMECKDALYHLVSELVRSGIFLVSQYIQWLITRGGLTDPQLVMPDGPPFSRLLAELPSHILGSSQKRSRDALLRRAGFRIADDAQDADMAIRHLRHALGLPAGVTDAVSMGRPFPIKKIARRIEDASRARKAEIASWLRNTVFGGELEHSSLNAFGQHDLSTRLFNSIRTVFEAAQEFSVFADVLRMLTKCSNPEVLASIADTITRYTFVFAALSCLKNLFSILHSRLREVQEQGIGARPLLASLAYLASRVPGMDEVAMQLKSDLAVSDRHNPVDACSPVSDNMVSRLSDHDGDLHEEVEKLLANGTSLDRNTMDRLFSAVIQRLQAYWSKGDEQQRVYGILLKRLRMFNPQHFDELMTRWLLYVRGLDTRATILHLYPLLVSIGCLEMPAILATASESPNALGAGNSRHPQSAVATSQIVQTTFRTRYMQEVLQLFMAPVSSESLLTPEERYRFGILQEQAKKESPRELLCLIQLALAEYTCARAQNDLEELPLDKEANQDRLLRLLKLLVLKDPVGVAKALQIRGPDAQIDGWIDRMTTKLLVTAAGEGTRVTFEQVLNLTNEFTLPFCHVKLLLSLSSNDQQQNAADSGERVPSNVELFMNAMEKSMDAQRVSWIGMLPSLSPDLTHHLKNQAQARFLNLLPSARNPPSMTLDRSMLQMRLQKAENFLAIMDTIIRGSGPMGFRQHQLVPVMVERFTDILELLQTLTPFPSQAGGLGGWGGQGASAAAAGGDSHIDLKSDILNHWLPLFLNFLTLHAQTFDTSKPGNEVRGRALMVCAGLIRELDLIHGPDFDTRQLGGRIFDLACVLVDNLAEDARLQCIQALKSPSDVKLRYIFSYQDNPHANLMLCHKERPTAMAIGTATGTGSPAPGTTPTHTPGVTPGPQNAVGAGSAVSGAGGSGNGGSYFSLPGHTQQAQAQGWHAAQQQQQQQQQQQSQQQQQQQQQQQYQLQQQQQQGGTGPIPSPAISINTNLTHLNLGNNSNPPTPSPMNPTRPAMMMVANPWGGYSWVPTMGGPQERLTPFNFRQWEMLSEPTSQVGENDTAVNLMLFESRKVQ

Gene
SRB8
Protein
Mediator of RNA polymerase II transcription subunit 12
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968)
Length
1661 amino acids
Function
Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex (By similarity).
Similarity
Belongs to the Mediator complex subunit 12 family.
Mass
191.934 kDa
Sequence
MSKTKNRNSLLSSHNRTSVSNSTKDELLAMKYVMDKPAIPLYPLNELSNSSESISEQNRYTSNSSTDELTYPDFKPWKDTTHLPKGKSEVEVEKLNNEAYLNKGYFEGPSVANEYYSARNLIQASLFSSSSNCDKVLKELSQHLVNSYRTRNEVINKIKYNSNKFKIPPRVTLTASKKEAWLRDLANPDEPLSNISNKLPHGIKNKMLVDILCSKNIPTSRALWLTKCVLYSELLVLKKKYQSRLPNNPHPVENTTSETFETQWLQEWTHQLVDYFYKFSKDMCNITIQEKKQVYLTKLNYLLNYVQALYIECLLDKSFFLTSILKFLKEGLPLDQSHVSELLAFSRSEGEESSLDKWLVDIDLNYGQRLISITLVKMFWKDILELDYLSKELSELLLLNYYFIERIPTYNTKSSNYSHKQNHTAALSSTLKLKLLSSISDTVNYLFKHNTNVFIIPNYWILVNETLYKILLSDVANSYDSEEQTEIRKQLKLIKYRNESLMLSMKDVQSSNFVDVNTARNLAKDRRRSNSLQQSLSQDTKNNYNSITGKKIPNTVENDNYFINRNSDDTLNIIDQLDRLKLNDTLAEMLIPSSISSSPDNFNDWRVNLKVVIYWAITIYREQMSSSEGILIICNFLKRKVLQNISVKNVNSIKAEFENEILEIIYNLAHCTDVDIIDYNLYVLINELYQLKVITISSYLRKLIASGLFYVSPSADGAQSHNENNSSVETHLAILQNLPVLNNKQCDSILRKWTPNGFNFEEKFEKGKLILKEELVDRLMSNSFDGYCDEKLTYIKNLKVGLKFLLVNWLTNYLKTSITKSPKLIHINPNIITSLYNFYALCDNLTVFFKVLIKFILRNEGKVIICYMDSLYLISKLIIRHFKLVKFIAGKSYESTTTGYELFKLIILNYKDLSTRDNDYYNFSDVWYFIDNAVEKNEPTYGKSSDGNNDNALKHKNFNQLLFAKETVDSPMRIHANSNTPQKNNDSYTATVFRNDLDLLLEAPIKLLNNTDITDFISTLELNVSNEAFNEISNTEESVIIIMEYYFKNIGEFTELHENLCMRLLINSKRSLDMTTRGIFFDIMKHFIINLVRTKPGIEKLITLFKKLMCFEVYQPHELFSTLRSILPRELSHEQMDALKYELLFGNPESDNKNLFNDQALVLRCIRYLYVKRHSNDVFITLLDSFSNEKETFFNSYALKAYNSKVLSFFRQFSISNTKFFMDGLSKVASNSDIISFLNLLIYISEEPIGSSSDLPRLASIIDEFNLPVCQVLIKIIIMNELRDSNKDKSIEKLRYILDMLLNNLKFHFVSYNSYFGELFNYLSWEHKLNILSIFEHNFLCNTEFIVSDDKFTENSVCLMSSDGRTNLLSILKDYFKKFSVSSLNTVTTSKEVFHNLSKFLLKVLQLANADIIGDSRRDAYNTISIFLRILIIHKLSLTSMIIEQDGQDLHFIKNLIALLESKFLCFNNEKLRILLYDLLLLMKSSITSSMILNPDSNLADDMTTDTSHQQHSPSNDYLSRSNPDGTEVGNSNSKYFGVSNISTIPNLSSVFNISEPNISYPLKKYTDDSKILCALMLEESELQKGGDIYALNDSKLILLPSRREALSSAFDILNETQQTVSKKRFKIESYELLEDTGIELNNGCINLSLFDAFTTKENPP

Gene
SRB8
Protein
Mediator of RNA polymerase II transcription subunit 12
Organism
Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)
Length
1654 amino acids
Function
Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex (By similarity).
Similarity
Belongs to the Mediator complex subunit 12 family.
Mass
189.211 kDa
Sequence
MSKARSRNSLLSSSNRAQFGNSTQDELLKLKFSMEKPDIGLYPLNDLDNGVDLNGDNSRSQHTAGSGVLSGNEVTYPDYKPWKDHTALPNDKKEQEHQKLNNAAYLNKGYFETPVVANEYYSARNLIQATVFSSTENCNEVLKELSQHLANAYKTRNEIINKIKYESNNFKIPPRVTLTASKKESWLKDLANPDLALSKIAEKIPHGIRNKILIDAVCNKSVPINRALWFTKCVLFGELVALRRKHQSRMSLNSPIPQSLDINTPEKFEIHWLQEWTQQVADYIYKFSKESSNFNTIERKQYYMNKMTYLLTYIQALYVEFLLDKSFFLALIIKFLKEGLPLDPLHVSELLSSTRSETDDLIQESWIEDLDLNYGQRLFALTLIKIFWNDILKFDYICKELSETLLLNYLFISKINAYSFKQSHVQNHKASIPEPLRQKILDMIGDTITYLFKFNTNVFIIPNYWMLINGVLFTILLNKNVTKTEGELDEISKQFDLIKYRNESLILNMRNVQPSITDRATPNSAGRRGSSIWNQSFVSAAESTATKIDIFDNEATFINRSSDDILKIISQLDSLKLNDELANFLKPVTSSSALTSTAIKGCPKWRTNLKVVLYWCITRHRNSRESSEDILIICNFLKRKVLQTLGPTRSSSQLKAEFESEILDIIYNIADTNSSKVVNYDLYVLINELYQLKVLTIASYLRKLIASGIFYVAPDAEDNILNDNSNSLVKTHLSILQNLPVINNRQCDSILKKWTSTGFNFKEKFEMGQEILKRELIDRIVNNTFDDQFESHIVYVKDLNVGLKFLLVNWVTNELKSAITESPKLIHINPLIISNLFNFYSICDNLTVFFKVLVKFILKNEGGMIIFYLESLYLIARLIIKHFKLVKFIAGNSYGSNSTAYELFKLIIQNYKDCKTREFDYFKFDQVWNFIDTAVESNYSSDKNTDSRSSGKRSGIFNKEQFDSPMKINTSENVIAKMEDRYTSADFRNDLDLLLESTFQPMDSNEVSEVVATLKLEFEENEMKSHRNVVPKVLDLLKSNLTEESEGLAAKLLINSQYLIKSDDVNAFDKLVQDYILELVKSDMEILLVAKFLKKLIVHEIIRINDLFAFFEPIAEDPAFRVKLKALMFDLVIGLSDEEREYLSNSQILQLEIMRQWYRERSTSSFLVLILKGIKTIEGSIFDCPLMEKYGSSIFRILNALIVANTKLLSDELISKISTEDSIRLLSTLNNENFTPINSLQDLERIASEVDEFNLPIFQLLLRVLTIKELSPLQENEIQERLKVLLESFLENLSFGFTPMNSYFGELFIYLPWEYVVSILGMLEDKFLCSTTFNFDQWDNDKSVLSLTNSVGNTNLLPVFNDYFKKFSSSSSNVVESSSSFFQALSKFLSKLLLIVNSDNCLEDTFEDTSSAISIFLRILIIHKLTLTRLIVTQDGEQFQFIKNLILLINSKFIAEGNEKLRILLYDLLLLMKSSVTEEVSKQTENELSEGTSPGFGMTAQSPPPVEDASKITEPLSSARPSSEAASFQTNPISTYDQVSSLFNLPEPTETNPFKDYITEDRVECALTLSEDELQSGGDIHGFNESNLVLISSSNDSTFSGAFALITNPHQRPKGQPFKLRSFEILEGTSTTSLNDGCINLQLFDSYTTKENPP

Gene
srb8
Protein
Mediator of RNA polymerase II transcription subunit 12
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)
Length
1617 amino acids
Function
Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex (By similarity).
Similarity
Belongs to the Mediator complex subunit 12 family.
Mass
178.101 kDa
Sequence
MIPHSSAGVQSWGQPLYAVYTGTGRADLSQPLGQPDRQSEQPSMPVAQTQGRPPALIDLTANDGDVLEREPPAKRLKIDVHAGSVANDGSPASAGVGESKSTPGATTSKPPSLSWRARPVWSFQSLLSEIPGSAEINGESAAGVVQDLKPPPPPSFSGPPWKFAPTDIIASDSAGEQDGASAKEVQTTPYHIETPSVAPVIRGEKVADFSPWMGNHPEDVLNEQTAKQGYYDRTQVSQNESNTARPSLYAQLKHRSGLQILSSVFAAALEKRQGHNMVTAPSTFKPPPRVTLTDNKREAWLRDLANPNVPLRKLSRTIPHGIRGRVLLDQCLTKWVPVGRAVWLAKCVGANEIRAFKRKGTSGALTIGLEAKWVRDWTANVQQFLEGVITSCGVADWKMKVTYAVNLTSRLFFEQLLDHDQYLEWFLTSLEAAPFNTLPVWLLMLGIYWSNILRYRKRGRRLAELLLDKLQLAIKSDSAPSLRPLIDRLSLHIRKLTLEHTSSMVLPQSWEKYKDLLSSCLNLNDNVHRTVFQILAERNARVQKPPKCEGTTQQPPQQRVIQLFDSICSSHDITSVSAASLRAIDDKAALVLKLLEWAATPFRYGVSRVYTGARLLRKWKIAGVDVDTCIISFLGESQMSDQLNMDNVYHIVSELVRSQTFSVGKYLQWLMAKGVADFSRSSDHQPLSGDLALLVQLPVSRLPEHVHNLRNTLLHRAGVEPSKEASTIAILKASIAERLPRIFGSVATSAVSCDPLPSDLTWTVKSELGQWIRRGVTEFGRDPRRAFQGLHSTTSAEHFALTPGEFYTVRDILESFGDLSILADVLKQATVCNDGIVLASAADTVNYHFRSFCVIGATTDLFKRLVEAYARLKRLGSTSLDLIFSLIDLGLRLPGELNTVALLRQDLSRIESKSSMAAPSPLSDHIPSSFNENDPLFLLKLDQLLSSASGIDESTLDTIFNVLIKQLESSGGHAKFSVNEICRYLSYLRPFHPKRFDTMIVRWVCGLLRSSTGGILSQVLPPLIGVGCVTIQAFVFLVRRLLKSDNKISNQRDLRIDLLQLLVPPPAGQSRYFDLVTYRFHLSRKEFLFKHPEEAFDIIRDAIALIDSESQEGNYRQVDLGHSAMVLLQILLTKNPESAVRHCSEKLIGQHPSAVTVLTRALDSLLGLDSKAGGHLFTSNDTFIFIPIDTGPATPDISVAEKVIELTNDFSLPFCQLKLQLLFNAESKGNVRNEIVDVMFKAAVADSRSRRSNWVGLVSLMSHDAVRQVKCHDIRERAEKNFFATPLFEESPDGCSSFAADNSSSLEAAKLYLAIIEKLAYSIPDVGPQAVVPVLTEKLDLLLQRLISMQASCSGTTELSHGVDAEQMIRSRTQFERALAFWFSALLRMIVLHRTAFSVPSAAVRPNALPEQTRLLISIFCISLARLPDSVLRLFPAADYFPHSMRAADCRPCPGILLQTHALDVAASLIDMFPDEARHQCARYLREKCPPFARVQNDSRFLYLLGPLGDSPSSNITLPVSIPSPAASGSTPAPTPSGNSTGGFSHPQQPAFVSGVPPGLPDGLNCAASHLCLQYRGRVIGAYPVRPWELLEDAAPIAGTNDTAVSLGYFDARRVRV

Gene
srb8
Protein
Mediator of RNA polymerase II transcription subunit 12
Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)
Length
1612 amino acids
Function
Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex (By similarity).
Similarity
Belongs to the Mediator complex subunit 12 family.
Mass
177.653 kDa
Sequence
MIPHSSAGVQSWGQPLHAVYSGTGRADLSQPLGQPDRQPEQPSMPVPQLQGRPPALIDLTTNDGDVLEREPPAKRLKIDVHAGSVAGDGSPASAGVGESKSTPSATTSKPPSLSWRARPVWSFQALLSEVSGSAEINGESAAGVVQDVKPPPPPSFPGPPWKFAPADTIASDSAGAQDGAPSKEVQTTPYHIETPSVAPVIRGEKVADFSPWMGNHPEDVLNEQTAKQGYYDRTQVSQNESNTARPSLYAQLKHRSGLQILSSVFAAALEKRQGHNMVTAPSTFKPPPRVTLTDNKREAWLRDLANPNVPLRKLSRTIPHGIRGRVLLDQCLTKWVPVGRAVWLAKCVGANEIRAFKRKGTSGALAIGLEAKWVRDWTANVQQFLEGVITSCGVADWKMKMTYAVSLTARLFFEQLLDHDQYLGWFLTSLEAAPFNTLPVWLLMLGIYWSNILRYRKRGRRLAELLLDKLQVAIKSDSATSLRPLTDRLSLHIRKLTLEHTSSMVLPQSWEKYKDLLSSCLDLNDNVHRAVFQNLAERNARVQRPRKCEETTQQPPQQRVIQLFDSIGSSNDITSVSAASLGAIDDKAALVLKLLEWAATPFRYGVSRVYTGARLLRKWKIAGVDVDTSIISFLGESQMRDQLNMDNIYHIVSELVRSQTFSVGKYLQWLMAKGVADFPQNSDHQPLSGDLALLMQLPVSRLPEHVHNLRNTLLHRAGVEVSKESSTIAILKASIAERLPRIFGSVATSAVSRDPLPSDLTWAVKSELGQWIRRGVTEFGRDPRRAFQDLHSAPSAEHFALTPGEFYTVRDILESFGDLSILADVLKQATVCNDGIVLASAADTVNYHFRSFCVIGATTDLFKRLVESYARLKRLGSTSLDLIFSLIDLGLRLPGELNTVALLRQDLSRIESKSSMAAPSPLSDHIPSSFNETDPLFLLKLDQLLSSASGIDESTLDTIFNLLIKQIESSGGHAKLSVNETCRYLSYLRPFHPKRFDIMIVRWICGLLRSTTGGILSQVLPPLIGVGCVTIQAFVFLVRRLLKSENMMSNQRDLRIDLLQLLVPPPAGQSRYFDMVTYRFHLSRKEFLFKHPEEVFDIIRDAIALIDSQSQEGNYRQVDLGHSAMVLLQILLTKNPESAVKHCTEKLIGQHPSAVTVLTRALDSLLGLDTKAGERLFTSNGSFIFITIDTGPAAPDISVAEKVIELTNDFSLPFCRLKLQLLFNAETKGDVRNEIVDVMFKAAVADSRSRRSNWVGLVRLMSHDAVRQIRERAEKNFFAIPLFEESPDGCSSFAADNSSSLETAKLYLAIIEKLAYSIPDVGPQAVVPVLTEKMDLLLQRLITMQANYSGTTELSHGVDAEHMIRSRTQFERALAFWFSALLRMIVLHRTAFSVPSAAVRPSALPEQTRLLISIFCITLARLPDSVLRLFPAADYFPHSMTAGDCRPCPGILLQTHALDVAASLIDTFPDEARHQCARYLREKCPPFARVQNDSRFLYLLGPLGDSPSSNITLPVSIPSPAASGSTPAPTPSGNPTGGFSHPQQPAFVSGVPTGLPDGLNCAASHLCLQYRGRAIGAYPVRPWELLEDAAPIAGTNDTAVSLGYFDARRVRV

Gene
srb8
Protein
Mediator of RNA polymerase II transcription subunit 12
Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40)
Length
1594 amino acids
Function
Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex (By similarity).
Similarity
Belongs to the Mediator complex subunit 12 family.
Mass
175.558 kDa
Sequence
MIPHSSAGVQSWGHPLRAVNNGSGHVDASQAVGPPDPQFEKLPTPVPQPQPRQPAVIDLTTSGGDAQELEPPPKRLRLDLPAAPSARDASPAPGSGGELRSTPGTGGSKPPSLSWRNRPVWSFQAMLSEVPGSNVMNEEDATAVAQGGKPASPPSLPVLPWKYIPESLGSNPTTSRASSPVKEVQTIPYRIETPSVAPVLKGEKVADFSPWIGNHPEDVLNEQTAKQGHYDRTQVSQNESNTARPSLYAQLKHRSGLQMLSSVFAAALEKRQNHSLVTAPSTFKPPPRVTLTDNKREAWLRDLANPSVPLRKLSRTIPHGIRGKALLDQCLNKGIPVNRAVWLAKCVGANEIRAFKRKGTSGTLALGLEAKWVRDWTASVQQFLEGVLGACGSAQWKMKMTYAVSLTARLFFERLLDHDQYLGWFLSSLEAAPVNIVPVWLLMLGIYWDNIMRYRKRGRRLAELLLVKLRQVTQPDKGGPLQPLVDRLSLYVRRLVLEHTSSVVLPGSWENHKELISSCLNLKDNVHKTIYQNLSERNSRLQLPKNHQDTAERSPQQRVIQLFDSIRSAHDISSASTACLKTIEDKAILISKLLEWTATPFRYGLCRVYTGVRLLRKWKMSGIDVDSYILSFLADVRVTSALNMENIYHIISELVRSQTFSVGRYLQWLMAKGVTNTPQPVPSDLCLLKQLPANRLPEHVRNLRNTLLYRAGIPVMEEDSAIAELKISIAQRLPNIFGAEMDSAMPTESSQPHPTWAVKSEIGQWIRHGIAGHCRDSPRYVYLLSRSTAPANNYRKLSGVSVAVDPGASALTPDEFYSVREILETFGDLSMLADILKQATRCDDDVVLASVADTVNCHFDCFCVIGATADLFRGLVESYARLKRLGNASLDLLFSLIELGLRIPSEFNTVALLRQDLTRLENKSALAAPSPLSDSIPLALSDVDPSFQEKLNQLLSSGGGMDESTMDTVFYSLMHILENSGSPAKLSANETARYLAYLRPFQPKHFDTMLIRWICGLLKSSTPSMSRILPPLIGVGCVTIHAFVFLVKKLLQSEKVAAVIPNLAGLRVDLLQLLVPLVSGKSKYADLVTYRFHVAQQEFFMKHPQETLDIICDAVALVNSETGSNPGQPDIAGCATELLDILLTQNPEVTVQYCLQGFIGKHSTSTTVLERALDNLLGFDSLAGPPTMSEAEKVVRMTDDFSLPFCQLKLQMLFNAESGRNVGNGIVDVMFKAAVEDTRSKGSNWVGFVGLMSQDIIRQVWKHHYHYKNLEAHGHPGTAKSLETAKLYLTIIEKLAYSVPEAGVQSVAPILVEKMDLLLHRLVIMQTNFNNVTMNRHGAATTQILQSRSNFERSLAFWFSAFLRMIVIHRSAFTMPSPAPRANGLQEQSRLLISILCISLARLPDSVIRLFPAADYFPHPIPSQGYRPCPGILLQTHALDVAASLIDTFPDEARQQCARFLKEKCPPFLQYQNDSRFIYLLGPMSDAAALNSLQAASLPSPAAGGSTPTPTPSSALPGAPSNPQPTAMTPAVTSASLSEGINCVASHLRLQYRGRAMGPYPVRPWELLEDAAPIVGVNDTAVNLKYFDARRVRA

Gene
srb8
Protein
Mediator of RNA polymerase II transcription subunit 12
Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Length
1591 amino acids
Function
Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex (By similarity).
Similarity
Belongs to the Mediator complex subunit 12 family.
Mass
175.528 kDa
Sequence
MIPHSSAGVQPWGHPLRAVHSASGLTDIPHALGQPDLHPEQSSMPAPQPQTGPSAVIDLTANGGEAQEREHPAKRLRLDIHSGSNARDGSPASAGLGEPKSTPVSTSSKPPPLSWRGRPVWSFQALLSEVPGAGEPNVESTTAAAQDVKPLSPPSFPAPPWKHSPADPTASSAAGLRGVTPAKEVRTTPYHIEVPSVAPVLRGDKVADFLPWTGNHPEDVLNEQTAKQGYYDRTQVSQNESNTARPSLYAQLKHRSGLQMLSSVFAAALEKRQGHSMVTAPSTFKPPPRVTLTDNKREAWLRDLANPTVPLRRLSRTIPHGIRGRVLLDQCLTKWVPVGRAVWLAKCVGANEIRAFKRKGTSGALAIGLEAKWVRDWTTNVQQFLDGVITSCGVADWKLKMTYAVSLTARLFFEQLLDHDQYLGWFLSSLEAAPLNTLPVWLLMLGIYWNHLLRYRKRGRRLAELLLEKLSKANKLDSSNTLRPLADRLSLHIRKLTLEHTSSAVLPHSWDKYKDLLSSCLNMKDSVHRAVIQNLSERNARVQRPRKCQETANQPPQQRVIQLFDSIRSTHDVTAVSIASLSAIDDKAALVFKLLEWVSTPFRHGICRVYTGARLLRKWKVAGVDVDSCIISFLAEGHDGSHLNMDNIYHIISELVRSQTFSVGRYLQWLMAKGVADCSKDSHQHHKHLSDDLELLLQLPVSRLPDHVRNLRNTLLHRAGIEVSKEEAMIATLKASIAQRLPNIFSSVTDSAMSCDVAQSELTWAVKSEIGQWIRRGVTEGRRGSTGKFQIAIGQPVLSADEFYSIRDILEGFGDLSMLADVLNQATNCDDGLILASAADTVNYHFQSFSVIGASTGLFRRFVESYARLKRLGVTSLDLILSLIDLGLHLPGEFNTVALLRQDLGRIENKSSMAAPSPLSDHIPATFNETDSLFPEKLDQLLFSGGGMDESTMDAIFNALITSLGRAEDRVKLSANDICRYLAYLRPFHPKHFDIMLIRWICGLLKSSTRTMLSRVLPPLIGVGCVTIQAFIFLVRRLLQSEKVASMIPHPNDLKIDLLQLLVPPPAGQSRYFDMVTYRFHLSQKEFLSKHPEETFNIIRDAIALIDSQDQDNHSDQGQMNLNQNAMVLLQILLTKNPESAVQYCTEKLITQHSTSMMVLTKALDTLLGFDTGPDPPNVSVAEKVIELTNDFSLPFCQLKLQTLFNAEAGSNVKNEIVDVMFKAAIADSRSRRSNWVGLVRLMNQDAVRQIRERAEKSFFAIPLFEEANEGRSMNNGTSLETAKLYLTIIEKLAYSIPDSGVQGVGSVLVEKMDLLLHKLVSMQTSYNGSTEMRHGIDAEQVIQSRTEFERSLAFWFSALLRMIVLHRSAFSIPPAPKSSASQEQTRLLISIFCITLARLPDSVLRLFPTADYFPHSMRQGDHRPCPGILLQTHALDVAASLIDMFPDELRHQCARFLKDKCSPFAQSQNDSRFLYLLGPLGDGPTSNATLPVSIPSPAASGSTPAPTPSGSLTAGPSNPPQPASASLGVPTGLPEGLNCGASHLCLQYRGRAIGAYPVRPWELLEDAAPIAGTNDTAVSLGYFDARRVRA

Gene
srb8
Protein
Mediator of RNA polymerase II transcription subunit 12
Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Length
1583 amino acids
Function
Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex (By similarity).
Similarity
Belongs to the Mediator complex subunit 12 family.
Mass
174.417 kDa
Sequence
MIPHSSAGVQQWGHHPLHALNPGAGRTDTASALGPSDLQLEKAPMSAPQPQLRQPAVVDLTTHSGDTSEREPPSKRLRLDLPSVASTGDASPASGNGEPRNTPSTSTPTAKPSSLSWRGRPVWSFQALISEIPGSGGMSEEDAAAVAQSGKPASPPPFPVLPWKYAPPEAAGNKSVKSRDSSPAKKVQTTPYHIECPSVAPVLKGQKVADFSPWTGNHPEDVLNEQTAKQGHYDRTQVSQNESNTARPSLYAQLKHRSGLQMLSSVFAAALEKRQSHNLVNAPSTFKPPPRVTLTDNKREAWLRDLANPSVPLRRLSRTIPHGIRGKALLDQCLSKWIPVNRAVWLAKCVGANEIRAFKRKGTSGAVVIGLEAKWVREWTAHVQQFLEGLVAACGTADWKMKMTYAVGLTARLFFERLLDDEQYLGWFLSSLEAASLNTVPVWLLMLGIYWDSIMRYRKRGRRLAEALLEKLRQVTNPEHATTLRPLVDRLSLHIRTLVVEHTSSVILPNSWAKYKDLVLSCLNMKDNTHKAIFQNVAERNARIQLSKDRQDSGQRSPQQRVIHLFDAVCSTHDVASAAAACLKTIDDKSLLVTKLLEWTATPFRCGLCRVYTAVRLLRKWKMSGVDIDTYILSFLTRTGNRASLTMDNIYHVISELVRSQTFSVGRYLQWLMAKGVSSSNQSDHSIDLYLLKQLPMTRLPDHVRNLRNTLLYRAGVPATLEDSTIAELKASIAGRLPNIFGNEVEHTMVVESPSLDLTWAVKSEIGQWLRRGISGHCRNATSAMAGITVPADRNVSRLTPDEFYHIRDVLESFGDLSMLADVVKQTTSCDDNIVLASAADTVNYHFDSFCVIGATSDLFRSLVESYARLKRLGTPNLDLVFSLIELGLRLPQECNTVALLRQDLLRIESKSALAAPSPLSDNPSTAINEADPSFRSKLDQLLSSGGGMDESTMASIFASLTNILTGRNEDVKLSANETCRYLAYLRPFHPKHFDAMLVRWVCGLLKSSARSTMPHILPPLIGVGCVTIHAFVFLVKKLLQSERIASKIPNPARLKMDILDLLVPPAPGQSRYFDLVTYRFHLAQQEFLLKYYKETLDIICDALSTNAAAAGINSELRSSATTLLRLLLAQEPEDVVQYCLQKISAQHSTFTSVLQDTLDQLLQSVSLHDPQVSMAENVIRTTDDFSLPFCQLKLQVLSNAESKENMGDGIVDVMFKAAVADTRAKGSNWIGLVRLMSPNSVQQIRERAEKEFFAVPLFAETLGDQSLSYAPNTEALETAKLYLTIIDKLAYSIPEAGVQSVGPILVEKMDLLLHKLVVMQTSLVTRQGVVSDQATQSRANFERALAFWFSALLRMIVIHRTAFNVPSSVPRATVVQDQSRLLVSIFCISLARLPTNILRLYPTADYFPHPISSEGYRPCPGILLQTHALDVAASLIDTFPDESRQQCARFLKDKCPPFLQFQNDNRFSYLLGPVPDAGTSNIPPPASVPSPAAAAASTPTPTPSSGLPPGSSTQQASSTLSGIPTGVSEDCVASRLRLQYRGRTIGPYPVRPWELLEDAAPIVGVNDTAVNLKFFDARRVRA

Gene
srb8
Protein
Mediator of RNA polymerase II transcription subunit 12
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)
Length
1582 amino acids
Function
Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex (By similarity).
Similarity
Belongs to the Mediator complex subunit 12 family.
Mass
174.506 kDa
Sequence
MIPNSSAGGQSWGHPLRNVDNDTARGDTSQAFNRPDIRSEGQQYTPALPRHPGQPAVIDLTSSANDAQEGQPPAKRLKLDITAESSANPASPTPATTGDSRVTPGIANSKPSALSWRGRPVWSFQAMISEVMSGAEATEEDAILAPQGKRPASPPPFPQPSWKGAPPEQFGSNATKASESDSSKKVQTTPFRVEVPSIAPALKGDKVADFAPWIGNHPEDILSEQTVKQGHYDRTQVSQNESNTARPSLYAQLKHRSGLQMLSSVFMAALEKRQNHNTINVPSNFKPPPRVTLTDNKREAWLRDLANPSVPLRRLSRTIPHGIRGKNLLDQCLSKWIPVNRAVWLVKCVGANEIRACKRKGTGGTLVVGSEVKWVRDWTSGVQQFLEGVIGACGSADWKSKMTYATSLTARLFFERLLDHDQYFAWFLTSLEGASLNMVPVWLLMLGIYWDSMLRYRKRGRRLAEVLLGKLHQTTELQRPTLLQPLAERLSCCIRKLVLEHTSSLILPNSWETHRDLILSCLNMKETADKTIFDSLAERNSRIQLPSSRSDSTRQSAHQRVIQLFDSIQSSQDIASTSVACLNALEDRQTLVIKLLEWSATSFRSGLHRVYTAARLLRKWKISGVDIDTYIISFLSTVQDLAQLDMDNVYHIISELVRSQTFSVSRYLQWLMAKGVARKSSGTSGEVLAADARLLTQLPMSRSPEHVRNLRLTLLARAGVSVDEESSTIKCLKSSISQRLPNIFEVEASNSKHINFSKHDLTWAVKSEVSMWIRQGVVKHLKDTTRISALTPGEFYCVREILERFGDCSILADVLKQAIECDDNIILASVSDTVNYHFDALSMIGATSDLFRGLVGSYARLKRSGNLSLDFVFSLIELGLRLPDESGTVYLLRQDLARIESKSALAAPSPLSDHIPTTFNEVDASFQERLEQLLSCGNGLDESTMGAIISSLTKILTDGGGAAKVSAKDACRYLAYLRPFNPKYLDGMLVRYVYGLLKSSSRPTMSQVLSPLIGVGCVTIHSFVLLVNKLSASAQTTGAIANPDSLRLDILELLLPQEESSADMVTYRFRLAQQEFLVKYPEETLNIISDAIPLFDADFHDANLGSRRPDLPACTVVLLRTLLAQNSSLVLKYCMQKLDGHSSFTTVLGKAVDILLGLDPEDEMEPSSQAERVILMNNDFSLPYCQLKLKLLFNAKAGNEVKNHIVDVMFKAAVTDSRSKRSHWVGLVSLMDQEAARQIRERAEGCFFSVAMFDESMDDTSLPSGASSLSSIESAKLYLNIIEKLAYSIPQAGVQSIPPLLVERLDLLLQKLIIMQINSNSVAASSSGSTIVSKINFERALAFWFSALLRLIVLHRAAFNVPPASGSKVDSLREQTRLLVSILCISLARLPENILRLFPAADYFPHTIQSHNFRPCPGILLQTHALDVAASLIDSFPDEARHQCVRFLRERCPPFLKFQNDRRFLYLLGPMTDTTIPSSQLSASISSPAAGGSTPTPIPSGTLSGGHSSQATQQMAALTGPFSGLSENTKLVADRLRIQNGGRINGPYPVRPWELLEDAAPILGVNDTAVSLKLFDARRVRA

Gene
SRB8
Protein
Mediator of RNA polymerase II transcription subunit 12
Organism
Coccidioides immitis (strain RS)
Length
1554 amino acids
Function
Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex (By similarity).
Similarity
Belongs to the Mediator complex subunit 12 family.
Mass
173.384 kDa
Sequence
MASLNTPECPVMSSRPSMSCGNSSSSGLAIQGHSQRPSQTDPSAVEQAAQDSVIDLTNSDYETCDANRATKRQKLDLRIDVPNTQRAPKARFSQAVSSPFALQDTVPPIRTGRPFWDFGEEVSGFGFQGSLESEIPNDEPEQPDSLPPLPVRPWRYRPQGHSSREETPRVNQNAGAEVQTTPFCIEVPEAAPIFDSGKPLDFYPWKGDHPEDSLTDQTAKQGYYDRVQVSQNESNTARPSLYVQLKHRSGLKLLSSVFTAAIDKRQSHCRVTGFSTFKPPPRVTLTDIKRETWLRDLANPSVPLRRLSRTIPHGIRGRILLDQCVNKAIPIGRAVWLVKCVGANEIRAFKRKGTSAAITHSLEVKWVRDWSINVHQFIESVVTACGTPNWASTMSYVIRFAARLFQEQLLDQALCLDWFLQSLRTAPIGTLPIWLSMLGAYWTSLVRYRKRGRPLAESLLEKLKTILSLEDSGPKKQIADRLSWLIKTFAESHPACFVLPLTWRTYKSTLTTCFCLHLSEDNRKIGALSNRNERIVKAEICRQSGRQSPSQQVICLLDSADSLNDMEILSSGCLNLHFDHGSLIMKILEWVSTSFRRGSARVYVAVRLLRKWRRAGMDTDNCIVNFLQQKADTPGFSPANIYHLVCELVRSQSFAVGKYLQWLMARGAVRNDAPMHPTVQLLAHLPRRKLPSHVWNLRNTLLTKAGFLLSSENQQILNTKRYIHHRLPEVITKPIAGDNEGLFTPSDLSNLNWTIKSEIGHWIREHVSLHRKRYLRTAPNHHNACAIEISALTPAQFFEIRDIIECLGDLSLLADILKHTSSSDNIIVLISAVDTLNYCADSFKAIGALSDLFKSALAGYAHVNKADVSIIELISSLLEVGMKLPGEIPVVAMLRRDLSHFDKKFTGAVSSPVSDHTGESVNIASPAFSEGLHQLLNSGSGMDEPNMNKIFDMLSRKLKQSKEPNASSHEIARHLSQLRVLNSDVFDRLMVKWIISTLKSSPRPHLLTFLPPLIGVGCVTFEAFFALIDRLLKSDSHRQSIQDVSGLRYEMINLLRKEIFYELGSIDLVSYRFKTTREEYITHHAYDALGLVNEALANVNPESTSNPPLVPLLCELIIQNLNAFGPEGAGRIVEEFPNCVDIIHQALDVLLGLKAQVGVQKTQSVVGLIDDLSLSYCLVKLRLLLDANPDGDAARSSIVDLLFRTAESDIRNGERRWLEVLNVLPVSAAHLIRQRAEREILSLSLISSSLTTFSSEEDALIYLCIVEELSYSIPDEFSPSSMGADLGDKMFLLLQKTVELANAKKGTDLESGASSTALGVAELSIGVWFFVLLRLVALHRSLVPPNCDSRTEINHQTRLLVQICCISRSPLFARRSTQSFISSISTFTKCDSLLRMLPSSWANLQLQALDVCSTLVDTLSDEARYECARFLRDKCPAFLHPQNDARLLFLFGPIIESQSITTHGSSRASTSTPVTNLTQHVQSTPPPSQNTLTPGMVEEPNLFTNKLRFQQNGRITGPYPPKPWEMLGDAAPIIGINDTPVNLAYFGTRQSKRL

Gene
SRB8
Protein
Mediator of RNA polymerase II transcription subunit 12
Organism
Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)
Length
1547 amino acids
Function
Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex (By similarity).
Similarity
Belongs to the Mediator complex subunit 12 family.
Mass
170.654 kDa
Sequence
MTSRPALGTHGSGAPSRNQVRRPSKPANALPPDCIDPTLEDERPAAHNGASEARPPPRGRPHIFYSTLASSAFDLPIHSFPYQPTVNLPVPPRPGSLHLRDASQQRQILPGGTGVKDAPKLGVPETVPIPVHFPGEKAADVFPWTGTNAEDTLSEALVKAGVSNKPQIMNETNTARPSLWSNLKNKSGITTLSTLFVAVLEKRQQNGRLQTPNTFKPPPRLTLRDSTREGWLHDLANPTVSLRRLSRTIPHGLTGKVLLDQCLNKNIPLPRALWLAKCVGINELRAHKRKGQAGTVTWGRGWTSSVEQFLDSVISTIGQGDWKLRITYALQLATHLYKEHLLDDDHFLGWIPFGLDMCSSERLFIWLLVVAVPHYWNDISSCRQRGKRLAESLLNHLAKLSPIEDLAAPSTALQFLENSLLKLVTTRPACLLLPISWPKHSAALKALVTKRNLPQTAQAVEKLDGRNTRLLSFVRNGKSSSRTGAARVFHKLDSINYAAPIRIEDLSYECMEITSNAVQLISTLLHWACSCYRAGSHRIYLATRLLRRWSHLGADVYEGIIVYLQSMSWVKSGEIHVLLRIVAELVRSKHFSVGRYLQWLIATGSLGCDASLSLPSSWPVRLITEVPLTGLSDQVRTLRSTLLRGTAHSTELEEQALVNVKQSISQAVPAIFGLSLTIPSRIELNFAKLSGTIRLEIGIWLRQQVAQHAEVNEQSYLEQCEDLAILADVIGITASSLDMAVLASVADTLLYHMKTFRAIGAFDPLLGRLAMRYAAIRTVKFPERELLLSFQNLARTAQPDGQLLQLLAYDLSRLDQKNAVAACSPASDNMGEVMQHAGTCSDDEIERILSSGTSMDQNMMSRVLRKLVRNLEEHVDKGYRQFENHPAWFWRLRNFDEATFDVVLREWLETSIMACQLHILQIAIPPLVASSCMELSSFLDILRSCLANAKATQVLEPATIAIDLLRLLLPSGLSAMSCSSQDAYRYRTEQYKLCFTSDTRIIHCIGEVADLVLSTPSNSMLQTVSSLLSSETVLSIVKEHVVSDPDCLSKMKTGQSGQASFNTCFKTLLNGLLDPSGQWCLADISPEEQIIAVFKAASELSLPLCQAMIEHIFASSSALDTHAVDRLSVTVLNAVRTSMEKDQSQGLELLTNLEGPLADKIRSHAEREVLDASYFLLRGSTDGIASDCIVTAKMMQKYLTVIELTMGETPQADEQFAMLAALTDRFKGIFHALSECGGLGTPTNQATASPVVQVLAALLSLVASHGPQLLRNATQSHQAALMVALQDIVTHASLELFPSIIEHVFDVLIVLSDHISEDVRNQIARLESAKSTNSDRAYFIHSQKAPIDGWLMLTKPVIPPLEPPQPPNPNTTQNQSSPYQSPQMTSNTAAPQHRYFNQQQQQSQTLQPSQQTQHMRTYPQYAQHAAQPNRHLPAQLQRTPSHHASLSPLQQMQHMQQLQGLAQQRASQPSPIHSQRPTSVASPGGMGGLAGGNAAPSKAHTSYVNQQRDTQQYPFVQPRWEILAESSGNPTLNETAISLSLFGARRV

Gene
SRB8
Protein
Mediator of RNA polymerase II transcription subunit 12
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
1427 amino acids
Function
Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II RPB1 at serines 2 and 5.
Similarity
Belongs to the Mediator complex subunit 12 family.
Mass
166.861 kDa
Sequence
MNNGSGRYLLTPPDDLHPYVPSSKPQEQVYPDFKPWEHTAAEDQILANFVAKGFYHTPMVNFESISARSSVHESLVTQSNILSQQFDKIIKIREDHINKIPSNSTTTLHGPGFQLPNRITLTDHRKETWLHELSSSHTSLVKIGKFIPHGLKRRQVIEQCYLKFIPLKRAIWLIKCCYFIEWKSNHKKKRSNAAGADDAISMHLLKDWTDTFVYILEKLIFDMTNHYNDSQQLRTWKRQISYFLKLLGNCYSLRLINKEIFHHWLVEFINKMENFEFLPLSLHILMIFWNDICQIDTNAPVAATITSSQKEPFFLVTKITDMLLHKYYIVSSSKSMINDENYIINDIKKNNKIKLNILKILSSLILKIFQEQSLEVFIFPTSNWEIYKPLLFEIVSNADTNQNSDMKKKLELISYRNESLKNNSSIRNVIMSASNANDFQLTIVTCKQFPKLSCIQLNCIDTQFTKLLDDNPTEFDWPTYVDQNPLTMHKIIQLILWSIHPSRQFDHYESNQLVAKLLLLRINSTDEDLHEFQIEDAIWSLVFQLAKNFSAQKRVVSYMMPSLYRLLNILITYGIIKVPTYIRKLISSGLLYLQDSNDKFVHVQLLINLKISPLMKSQYNMVLRNVMEYDVKFYEIFNFDQLVEITEQIKMRILSNDITNLQLSKTPLSIKIMVAEWYLSHLCSGILSSVNRTVLLKIFKIFCIDLEVFHHFFKWIEFIVYHQLLSDIESLEALMDILLCYQKLFSQFINDHILFTKTFIFIYKKVLKEKDVPAYNVTSFMPFWKFFMKNFPFVLKVDNDLRIELQSVYNDEKLKTEKLKNDKSEVLKVYSMINNSNQAVGQTWNFPEVFQVNIRFLLHNSEIIDTNTSKQFQKARNNVMLLIATNLKEYNKFMSIFLKRKDFTNKNLIQLISLKLLTFEVTQNVLGLEYIIRLLPINLENNDGSYGLFLKYHKEQFIKSNFEKILLTCYELEKKYHGNECEINYYEILLKILITYGSSPKLLATSTKIIMLLLNDSVENSSNILEDILYYSTCPSETDLNDIPLGSGQPDNDTVVTNDDKSDDDDHTVDEIDHVEYYVMMDFANLWVFQAFTCFCIKKIMENNEPAMAMEDLKNFIFQIIEITNSNDLCSQIFDQLKDMQTIEMITQIVEKDFCTSCLQNNNQKIDDNYIVVVIEIITSLSMRFQRETSGMIVISMENYHLLIKIIRQLSELNEGNLSKREIQIDAVLKIFSFHQDSIFQRIIADLSADKPTSPFIDSICKLFDKISFNLRLKLFLYEILSSLKSFAIYSSTIDAPAFHTSGKVELPKKLLNLPPFQVSSFVKETKLHSGDYGEEEDADQEESFSLNLGIGIVEIAHENEQKWLIYDKKDHKYVCTFSMEPYHFISNYNTKYTDDMATGSNDTTAFNDSCVNLSLFDARFERKNPH

Gene
SRB8
Protein
Mediator of RNA polymerase II transcription subunit 12
Organism
Yarrowia lipolytica (strain CLIB 122 / E 150)
Length
1362 amino acids
Function
Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex (By similarity).
Similarity
Belongs to the Mediator complex subunit 12 family.
Mass
151.979 kDa
Sequence
MNSSAPSPGPSSRLYRSINSRDDLSQQRYVLRPPDDIHPLVDPARIGDSVYPDFYPWKRSTDEEDARMVDNLQKGYAEPPSVPHESQSAKKSIASLLRIKSNMTALSCFIITAMHIRVDTCRITTPGTFKPPPRVTLTDHKREAWLKDLANPAVPLRKLSRTIPHGIRNKVLLDQCCAKRIAPSRAVWFARCVGANELRGLKRKGHHQMGNMSEAIWLQEWTECVVDVLQRSSVAFLRAEGEPQARQTAKQNFAYMWVVGLLSDDNTKDTKAGSGVAPGTGASTTSKLSSVEKLPVAILIIRTFWKPLLTFPNLAKKLAQNLLAELSKLEADAHSDKPFYQPTIKALSTLVNALFDAQPDAFVMPSKWVQLGSTFEAIVSDSESTRVRNEALVISDTPKTRRTRNKQAVIISILDAARAPFDKTLFNQIVDTRADFGTIIQTILAWAVSDSRVSVERVFIASHLVSQLSEGVDGDAVPSHIVQFLLSVKSHLDVRIDDLYALVTELCVLDIFQPQDYVRSLISSGVLYISRLSEWANVQLDILGNLPLVAVPSSCQVQVRYMVRKVAKYASYNENELLERTNNALRVLLPGVFDSQAEDVDMSSSSSSLSDSTNIPYSEFTQNTRIVVAENLYTSLCAAVERGYVPTTQEFAQYQLILENLHAWRLMCASIQLIVPKCTQSHLLYFLASATRYQWQAFACIADMPALVKVFMHQYRGLRKVRVSRELWDLVQFSAQQLPELKPELETLLKNSSSPQLSPISEVTPQTDSEATKDVNLPQALNDLLLHSSDVRTSCKMLANYKDDSQFSNQLMTWLRDQEVSLQLLQTLVFLVVYECTCIEKVGDLFLQIHNLRDMSGGSRLLLSLIARDLTQEYSLSTTEAFSLQFQRKLFADQHPRIYLRLVAQYLFEREVFQDPQWLDDVDTFCKEVAVHHPALFSQLIVDPVIEPDNAVAASSLQQLLNHLLKLDLGTGTSLADDLQQLITHVTPFNMFLAQTQLRLLFAHRGRISKDPVAMDTSPELTINSTTPSTDTTDEDVSVLFRVLSDPGLLKLPPFFGDLFSELPGELKGRILARAETTFLTSPNFPRVGEDNIVSLLIELADSLADSVTEDVCKTQTFALSSGLQRLVEASVREPHPPGLAEGISMFLKIAMIHEKSLMASEDAEVTMLRNHVVEGLQALLDSPFVATTPDLKATLQDTWTALKSELSEVAEPANSAPSKAGPTRDLLLYSTANDAFSEVTVRSFDLLEESNPTMGVNDAALNLALFNATIEKRIPIAWNNGHKRQLVDGGRGGRKTARGTDSSLVPTILEGIPRCMDEYSNHWELFFCFYLYTMRASEVHDLRANRASSFERRASSVELLA

Gene
SRB8
Protein
Mediator of RNA polymerase II transcription subunit 12
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Length
1358 amino acids
Function
Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex (By similarity).
Similarity
Belongs to the Mediator complex subunit 12 family.
Mass
158.482 kDa
Sequence
MSSSRYILIPPEDLHPLTSNTGNEQNIYPDFDPWAHTEIEDKILLSFVAKGHYTSAKVNFESISARSSLQESLPKVAGMLAEQFSKVVHLREQTINKVSGESEESIRGKAKFTDLAGPGFSLPNRVTLTDQRRTQWLQELSSPNVSLSKLAKSIPHGFKRKQILEQCYMRQLPLQRAIWLIKSSYSIEWKSLTSKLKPGQTNEGVVSQLYNLWTNSMVSIMERLLFEMPKYYNDTAQAKIWKPRVSYYINLLGNCYNMGLMDRGVFNHWLVEFVEKVENFEFLPLSLHLLNIFWSGICPPTHGIEAPDNSFLISKITVVLLHKHHMILQNKSMINDENYIINDLQRNARLKESLLLRLKAFILDIFHHQSLEAFIMPNQNWDLYKNCLYEIVTMDKTSNEQAMVIKRKLELITYRNDSLQFNLLKQYKMKSSSLYESDGVEIDNLCDMQSILNVPFLDPEMTKILDNATPGYDWTLFVQQRFTCIEKVAQMIMWATNPSRKARYDGAHLVAKLLLLKTTSQENLPDYNMEDMIWKLVFHFSKLSERELSNIVELPSLYELLNIFIGYGIIKVPTYIRKLISSGIMYISDSKDKFFHCELLINLKISPLMKNQYNMMLKNIMEYDATYYVRYNYEQLQIQLNTAKEQMLQEQFEHISCLPISVKIWVSEWYLSYVCSPVDNVLKPVDKGTVIKNFTIFGLYLKEIFHFYKWVEFIVYHQLLADINALSALIDVLLYYENLFPLLINDQILFMKTLIHIYSKGLKNKDNLSYNITEFNPFWKFFMKHFPYLVEIDSDLQLQLGEVYESEKIRIEKLTKSSVDVITLYCNINQVNEESFKFGTHNFPGIFQQNLKILLKTESADACERARKGLSLLMLANLGDYTKFMSIFLKRKDYTIEQLVKLISVKLLTLDQIQKIIGDDILREILSRNNYGEGLWYELHKRNFIKKNFKIVLSMYRNSTSLDDRKLFLDLLVFYGPNSRLQEQVTTIICNCLRESNEDYSLILSLLRYGTKNIDQGTQETINIAKLYENLNFTNLWIFQAFTNYYTEALFNGATSDGQTITNFVFELIDLTRYNVLCSHLFDRVANFDVLEKLLEVFEADFFKKCLSEDPDDVHFLAVMIETIMNLSRKMNQSSAVISMNNESFRLLQATMLKFTSMNKTALCNSEMKLSIYLKIFIVHQKFIFQKVCDSLRQDRYDAEADLVKSLRLLFENTGFKLKLRLLLYDILSSLKSFVIYECTKKSESKRETRKLQISEALQNLPPFHISSFLDDMSISAHGDFDFLGLTEQPTPAEPEEGSQFFLYNKRTREYECGLNIEPFQLLPNHQSREPGSSCHFFNDTALSLSLFDARFDKKNPT

Gene
SRB8
Protein
Mediator of RNA polymerase II transcription subunit 12
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
Length
1358 amino acids
Function
Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex (By similarity).
Similarity
Belongs to the Mediator complex subunit 12 family.
Mass
158.953 kDa
Sequence
MIPSKYKLAPPDDLHPYSESERAKHKIYPDFDPWKHTKEEDEILLNFVSKGYYSTSKVNFESISARSSLQDSLPKLSSTLSEKFSEVVRIREREINTIKGNSKDGMAASKFTDLCGPDFKLPSRLTLTDHRKELWLQELSSPYTPLHKITSFIPHGLKRRQVLEQCYIKQIPLKRAVWLIKCCYSIEWKTGIAKYANSPQEKDKFNAHLLKEWTDNFVHILEKLIFEMTQHYNDSVKLEAWKTEVSYFLKLVGNCYTLELIDKNTFHFWILQFVSKVENFEYLPLPLHILELFWSGICNTNSTKVNESESNPLYMVTKLTDILLNQYYIILHSKSMINDDKYIINDIKKNNSIKESLLASIQKLICILFKQQSLEVFLFPPTSWEKYKPCLIQITSALYRKSDEVAEIKRKLELISYRNETLKYTPPISENKVKDDLILTTFTENSGSITVVELSQVDTGLTGALDDNATDFDWTSYSDQEISTKIQIIQIILWAIHPSRHSHYEAGQLAAKLLLLKINTMDGFPEYEIEDEIWSLVFKLAKLSDKSKALPAVLEALYSLLNTLIVYGLIKVSTYIRKLISSGILYLTESNDKYIHCRLLINLKMSPLMKSQYNMVLKNVMDQDPEYYNNYNFDQIVSIVEDLKVKLPNGDAIEYSNYPMSVKISLGEWYLTYLCNGKLVNETRESLTEKYVLFAHQLNTNHLYFKWIEFIVYHQLIEDIETLEYLMEVLLRYKKLFSQYINDHVLFIKTFIFIIRRILKERDSIAYSLTSFMDFWKFIMKSYSLEIRADTDLRSEMSAVYEEEKAKKEITEGEKDSWMGLYQNIHPDSTSLDQNHTGFSELFLTNLKTFLSSKQDKQAKKKARYNLLLLMQAKNRDYSKFISIYLKRKDFKTSDLVNLLSSKLLTLDQIKNTYGLKYVLELFDIESESNCVFYEYQKRCYIELNYKSVLSEYNVVSHHEMNRFIFKIVNHSTSAKLKETASALLTKNLEANKDKAIQLFYQLVYYQNNLEFLSSEELQEFAVNNSPQKLYSYLDFTNLWLFQSFTKFYIHETFQNTNEDKVKVGDVIFSIIETTKYNVLCAKIFEDIRDHRVTDLVIELFEQDFFKKIISGEEFKAEFLQMLIEIINHLSMHKGKTNDRSGEQSHTSYELCVQVMAHFQQLSDSELSAKEIELDVFMKIFTVHQNSVFQEILRDTESSSAMIESLFALFERVNFSLRLKLMFYEVLSSLKSYCTYEAGISDEQSRTKLMHKLMCLPPFQVSSFFPEEDDTDCTRDPALSLGLDLGTASANSTSSTTPSEGTHKKRCAIWDKRLHKYTGELQRKPYYCIKNYQDTEDINNCSLNLSLFDARYERNNPR

Gene
SRB8
Protein
Mediator of RNA polymerase II transcription subunit 12
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Length
1322 amino acids
Function
Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex (By similarity).
Similarity
Belongs to the Mediator complex subunit 12 family.
Mass
154.88 kDa
Sequence
MSPSKYLLTPPEELHPLTDSNPQIYPDFDPWIHTKEEDKILKEFVAKGYYTASRVNFETISARSALQGSLPKVSSLLGDELSKIIEIREQEINRISTLDIEDSTRFTKWSGQDFHLPNRVTLTDQKRNLWLQELSSSNTSLRKLTKSVPHGFRKRHILEQCYTQFVPIYRVIWLIKSCYAIEWKGMISKAKGETTHEELLSTLYKDWTDNMVLILEKLVFEVSKYYNDPGQLKYWKLRIAHYLKILGNCYEMELLNRSTLHQWLVDFLSKIESFEFYPMTLHILSIFWSGILGTTEEDTEIESSFLIIKLSEILLRKYHIISESKCMINDSKYIINDVQRNSKLKESVLLRLRQFISHIFHTQSLEAFIMPKQNWNIYKNYLYQILLQNVSDEETPKLKKKLKLISYRNESLRLGSLDVEPSRETSPFSTELTLDNVFSGNILNLKNVSPELLGVLDSGLSGSEWSLFIDQKITKMEQVIEIILWAINPSRKHRYDSCHLVAKILVLKINSQESFQEYSIEDVIWSLIFHFSKLSKLELQKIVWLPKLHQLLNVFIGYGIIKVPTYIRRLISSGVLYLPESENKNFHCKLLINLKISPIMKSQYNMVLKNVMEYAPHFYEKYNFDKLVSIFESLKPKLLSGDFERLEEYPGSIRIMCSEWYLSQICFNQGELQKVNNHKIIKTFQLFCINLGELHHFFGWAEYIVYHQLIDDLENLEVFTDILLYLDKAFLLLINDHILFMKTLLHSYMRDLRIKDKAAFELINFKSFWKFFVKNCANMIEMDSSLQNQIAEVFELERHRKDHFTKMPNETVSLYLEITGNKNTKFEEQNFPSVIQQNIKKVLHNPEDESNCRKLLLLCKASHASEYNKFLSIFVKRGDFTVHELLKLISLKLLSFEVIQKTSHFDLLCELVSQVSFNYGLNFENEKNAFVKRNFKQITLQLFSRPTFRDTLVRMLVEYGPNSNLSEKSAQVVSHILREEKNMSIIRDMLIYGMNIENEAIDNTIDLYRYLNFTNTWLFQILTEFNVKNSNAEDLSDFFSSIVGAIGYNSLLPKIFSNISDKKQVSTLLTVIERQFLARVLETEKSALVFLHIMMDTEIVLSRHLVNMSSLGMDSEVLELFKNTIATFAKMPNDTLKKYDENLNELLKIVIIHEKFILRHCFESIELRDHYMVDNFYTLFHNTGKDLKLKLLLYDLLTSLKSYILNETKDQALHSIKMPSVLNQLPKFAISSFLDSEGTEDEFLDKDEPSLIRLGICDKQAKTNSALKYFVFNKKSSQFDCIFKIEPFQYLVNYQEPLEGELNNTSLSLGLFDARLEKTNPS

Gene
srb8
Protein
Mediator of RNA polymerase II transcription subunit 12
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
1134 amino acids
Function
Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.
Similarity
Belongs to the Mediator complex subunit 12 family.
Mass
131.246 kDa
Sequence
MSNRDSANPPGFNDAVPLAICYIDSSTSSHDEYLTLLQSKVSAPDKNFRDETVDGAPFLAGDAISKGHRYSPPVRSDRASAQGLLQQHLEKSSTLENLKRYSSTLLGRQNDAVIDEPFAPFRPPPRVTLSESRRDRWLQGLSDPMVPLSSLIKTIPHGLWGEDILRMLVKFRVPFTRAIWFIRCAGVNEARSFLRKVQTTDITEWVKNWTDVAAGFLISFISSFLNADIYSFADDYTYLLKLFGRLLAEELVSPKHFLLRIVSFSGDSSLKSFSLHFFALQFFSTSLIQYTHICRKCVITILQSYQQLIVDQPANLLKFSLLSKKVSHFLFTLAQKNIESFFFPTEWDKLKPTIILLWKDFPNYSTLLSIMQERNSKAMYMYKPVTSSIRFLQIISCLSFPVGWRTLAKDLFKLLPVYTGVPLLLHWCINCRSIFSGDRNFIVSSIFDNANFDRNLIVDLTLSFVLKLHPLEYNECVAAAQLLDHLAACGYFFFSKYIARLASLGYLRESMLNSSFMDDQRKILVQLPILRMSQQLKNKIYYILSKGNYFVDWSICDEYVKRFKEDHFSFMFKKEENYAIITLSLVKIASTPMSKLYEDYLVMLFAFHYSMFQVMTKLIADNLVHFSFQSCACQTLFFICSVVPKTESQKLLLNEMGKLFQVELNFSYDSPDVNLLIEQFYEITSYESNYDDAFVEYKDATVANRKDFIEFLFHNITVSSKHTAVIFTSDLLMVLKIALNHPPYFDDLATTTFSSLLKRDECTILSFFKILQFYGCKLLSVDQIWAVVSDVYEAQDNNTTLKQFFNYLLDESTWPEGYLEERHWRSILCKEARKHDSGLKLFKLGIKLCTRNEQIMKTIWSFIHVHDCNVISEVIPDQRFLRTLTEHFMIDLRQLDIVTCLKKALVTLDEFSAPLYATWLTTLDDDELSELTDDVVQKKVLESLDNYKSGIWKLVLSGLPNCKTVFEHLLLFSLEERLDLPAAFLQDLIGASAYVMEQVPDSWFLEKLPCPLTQSLQSFSHLSNHIEVLDSTRQSRLTFLCHLILHMHGFVELTDQLATLESLTIRKCIYRNQELLDLLLFSIHLVKPNVETNDEVCNTLKAWENIESRPYTIDFPEALQQYSPRIVLYEPTFW