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srb5

Gene
SRB5
Protein
Mediator of RNA polymerase II transcription subunit 18
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876)
Length
351 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 18 family.
Mass
40.184 kDa
Sequence
MVHQLSLVSSIPHNKYLQTISTLQALTGLIQPESISTYTLLAKPSYAFKPKFEPGKVNQIEQYYMRCITTWNSDKQGDDEKVEKGFDISEPFINKESNIVVRKLFTEEDSVERVWTLQVSDIPVAGKNQGCCQQQIYESTLVHTHTAIEIKVGNGDPIDIDTNNDKQGDNNTDKPKQEHDGKLPEAIDEDIIKNGDEKKTTHDDNDSDIMEIDEPNPETQTLPQSLSNGVSQRTTRKDSFLIFLSDLGYEVINQYWQKGVRFFYGDIIIEIYKIFIRDESSQADSNEGIKLKLLDDSNQFQIKAYININKSTEIDSINSGVKELIKLQEFLKNLFVLEIPDRMFMDSRIKQ

Gene
SRB5
Protein
Mediator of RNA polymerase II transcription subunit 18
Organism
Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)
Length
348 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 18 family.
Mass
40.076 kDa
Sequence
MVHQLSLVSSIAHGSYVQTVSTLQAFTGMLSPQPIATYTLLTKPHEVFKPKFEPGKVNQIEQYYMKCITTWSDGSEFDLASAVIKENGSSNVFSGRLFHAEDESVQRIWTLQISDIPIAGKNQACSAQTIYESTLIHTHTNVKSEENKIDAMDVDLEHKDKSDVKGDTKEKEEDKKEEDKKEEDKKEEDKKEEDKKEEDKKEEEKVEKKNDEVKHSEVNLEDGAETGSGHKDSFLQFLEDLGYETISQYWIKGIRFFHGDIVIEIFKVLVRDDEVTEPKEEGKIALKLLDESNTFQIRTYINIAKSTDIDLINQGTKELLRLQEFLKNLFKLEIPDRMFMDSRVQVRK

Gene
SRB5
Protein
Mediator of RNA polymerase II transcription subunit 18
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968)
Length
341 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 18 family.
Mass
39.001 kDa
Sequence
MVHQLSLVSMVSHSNYVQTISTLQALTGLLTPQPISTYTLVTKPHDVFKPKFEPGKVNQIEQFYMRCVTTWNDETGNKFDLASPVLENDTDILVNRLFLGVDDRRNWTMQISDIPIAGKNQACSAQTIYESTLVHHHTKVMDKEKVQSDVSNESNMDIDDKDEDKKENIKKEESGEEVKGSGEEVKGSGEEVKGSGEEAKKSGEEAKEHSEGNASQTVKELVVLNRRDSFLQFLEDLGYDVINQFWMKGVRFFHGDIVIEIFKVFVRDDEKDAEKDKIRLKLLDPSNTFQIRTYINVPKSTDVELINQGTKDLLKLQEFLKNLIKLEIPDRMFMDSRVTYK

Gene
SRB5
Protein
Mediator of RNA polymerase II transcription subunit 18
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
307 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins.
Similarity
Belongs to the Mediator complex subunit 18 family.
Mass
34.289 kDa
Sequence
MVQQLSLFGSIGDDGYDLLISTLTTISGNPPLLYNSLCTVWKPNPSYDVENVNSRNQLVEPNRIKLSKEVPFSYLIDETMMDKPLNFRILKSFTNDKIPLNYAMTRNILHNTVPQVTNFNSTNEDQNNSKHTEDTVNESRNSDDIIDVDMDASPAPSNESCSPWSLQISDIPAAGNNRSVSMQTIAETIILSSAGKNSSVSSLMNGLGYVFEFQYLTIGVKFFMKHGLILELQKIWQIEEAGNSQITSGGFLLKAYINVSRGTDIDRINYTETALMNLKKELQGYIELSVPDRQSMDSRVAHGNILI

Gene
srb5
Protein
Mediator of RNA polymerase II transcription subunit 18
Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Length
278 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 18 family.
Mass
30.905 kDa
Sequence
MHELLLFASVPAHQHHELLQQLAGLTAMQPQHRFERRLIFKAYRKPGLVNVRVGASQDVQGAEMQRLNKMLNGGMFYTQVVGPVAAADFGAPAPTVSVGDQDAQMSGMGVGVSAGVDEKPSTRPHRYDYDDQPWKLEFRDIPEAGTRSAVTARLMASASLPRGDIMVPMNAWGYNFVTEYAVEGDIFILHDIVIFLHRVLHYPTESQEPRRQLPALPEMTPLERSGSYVLQAAITVQDGASQETMKIASQHLFGLREQLKSAVRLEMADRLSLDTRAK

Gene
srb5
Protein
Mediator of RNA polymerase II transcription subunit 18
Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40)
Length
273 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 18 family.
Mass
30.477 kDa
Sequence
MHELLLFASVPAHQHHELLQQLAGLTAMQPRHRLERRLIFKAYRKPGLINTRVGASQDLQGNEMQRLNKMLNGGMFYTQVVGPVSEADFGAQSSAASSGDPDAPMSGTDTGTNFEYHPYSYENQPWKLEFRDIPEAGTRSAVTTRLMASASLPKGDITTPMNAWGYSFVTEYVVEGDVFILNDIVIYLHRVLHYPAESSGSHEPRRQLPPFQQMSPLEKTGSYVLQASIAVQDGGNQEMMKTASQHLFGLREQLKSAVRLEQADRLSLDTRAK

Gene
srb5
Protein
Mediator of RNA polymerase II transcription subunit 18
Organism
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Length
271 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 18 family.
Mass
30.045 kDa
Sequence
MHELLLFASVPAHQHHELLQQLAGLTAMQPRHRLERRLVFKAYRKPGLTNTRVGASQDLQGVELQRLNKMLNGGMFYTQVVGPVAKADFGGNPSSSGDPDVSMSGLEEKPSSSSSSYSYEDQPWKLEFRDIPEAGTRSAVTARLMASATLPKGDITAPMNAWGYSFVTEYVVEGDVFVLNDIVIFLHRVLLYPTGAQESHGPRRQLPAYQELSPLERTGSYVLQAAITVQDGGNQEMMRTASQHLFGLREQLKSAVRLEMADRLSLDTRAK

Gene
srb5
Protein
Mediator of RNA polymerase II transcription subunit 18
Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)
Length
268 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 18 family.
Mass
30.087 kDa
Sequence
MHELLLFASVPAHQHHELLQQLAGLTAMQPQHRLERRLVFKAYRKPGLVNVRVGASQDLQGAELQRLNKMLNGGMFYTQVVGPVSEADFGAPASPVADQDAHMSGTDEKLSVRTHYYDYENQPWKLEFRDIPEAATRSAVTARLMSSASLPKGDITVPMNAWGYNFVTEYAVEGDIFIHNDIVIFLHRVLHYPTESQEPRRQLPALNEMTPLDRSGGYVLQAAITVQDGGNQETMKIASQHLFGLREQLKSAVRLEQADRLSLDTRAK

Gene
srb5
Protein
Mediator of RNA polymerase II transcription subunit 18
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)
Length
268 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 18 family.
Mass
30.087 kDa
Sequence
MHELLLFASVPAHQHHELLQQLAGLTAMQPQHRLERRLVFKAYRKPGLVNVRVGASQDLQGAELQRLNKMLNGGMFYTQVVGPVSEADFGAPASPVADQDAHMSGTDEKSSVRPHYYDYENQPWKLEFRDIPEAATRSAVTTRLMASASLPKGDVTVPMNAWGYNFVTEYAVEGDIFIHNDIVIFLHRVLHYPTESQEPRRQLPALNEMTPLDRSGGYVLQAAITVQDGSNQETMKIASQHLFGLREQLKSAVRLEQADRLSLDTRAK

Gene
SRB5
Protein
Mediator of RNA polymerase II transcription subunit 18
Organism
Coccidioides immitis (strain RS)
Length
267 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 18 family.
Mass
29.815 kDa
Sequence
MHEHSLFAPVPAAQHHDLLQQLAGVTAMQPNRIYERRLVFKPYRKPGYLKPRPGGSQDVQAPEVQRLNKMLNGGLYHVQVVGEVKLTDFGTHPSTVDATMGGTDFGNQHQNEYDISNQSWRIEFKDIPDAGTGSAVTSRLISTSRVPYGDIVPVMKAWGYDYVSEYVLEGDMFILDDTVILLHRILNFPAKHHLQGLPAFYLPPLQEMVPLDSTGGYLLQASITVQDSGNPDLMKATTQRLLGLKEHLKSAVRLESADRLSLDTRVK

Gene
SRB5
Protein
Mediator of RNA polymerase II transcription subunit 18
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
Length
266 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 18 family.
Mass
29.887 kDa
Sequence
MVQRLSLMATIADDDFPLFKTSINILTGSPAVVYANLMVVWKPNPNYEVDNLNSKNELVEPTRMTTATSIPLELILNDPVSKNNGVDSDEILNTMKEQEFPIKQEQLFDMINNPSNNTINWTLTTADIPAAGSNRKVSMQAIQEATIVHQAGNNPTLANVMAELGYSFDYMYVTVGVRFVHKRDVIIHCHKVWDIAEDNIIQVTKGGYVVHTFVTVNRATDIERLNLAEANLLSLQRDLSGYLDFKVPDRKSMDSRTNLTQKDITL

Gene
srb5
Protein
Mediator of RNA polymerase II transcription subunit 18
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)
Length
265 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 18 family.
Mass
29.717 kDa
Sequence
MHELLLFASVPSHQHHELLQQLTGLTAMQPRHCLERRLIFKATRKPDLANMRSGTGQGPDIVRLNKMLNGQMFYTQVVGPLSEADFDGKPSSSDSQDVSMSGTHEAAGSSYDYDSQPWRLEFRDTPEAGFRSTITARLAASAALPKGDVVPSMNAWGYSFVTEYVVEGDMFIYNDIVIFLHRVLQYPATGQEPHEPRRQLPSFRDLAPLEKTGSYILQAAITVQDGSNQELMRTASQHLFGLREQLKSAVRLEHADRLSLDTRAR

Gene
SRB5
Protein
Mediator of RNA polymerase II transcription subunit 18
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Length
258 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 18 family.
Mass
28.727 kDa
Sequence
MVQQLSLYSVIDEGSFDLLIATISALSGRSPVLFANYNHVAHPNPNYAIEKVNAKNQLVEQTRVQLMQEIPFEKLQTEEYSYKLCTKMTGDGPPIETEYLNSLMRSCGDGTRPWSLSLWDIPSAGKDRKVCTQAVVESVVTSTGGAHSSILSFLAELGYVPGYQFVQLGTQFYLENGIVFQISKLWALHGESGKTSAVTKDGFLIKAYLNVPKATDLESINQGTAHLQQLKRELRDYLELSIPDRKSMDSRVGHLNDF

Gene
SRB5
Protein
Mediator of RNA polymerase II transcription subunit 18
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Length
255 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 18 family.
Mass
29.006 kDa
Sequence
MVQQLALFSAIEDESYPLSVETLTILSSNRPRLFANFNKIYKPNPSLQIEKVNAKNQLVEQTRVKLSTAVPLSKLGNGAELNYHFMEKLSNDDIESFNVKSYIQDIDSNNKTNWAFQISDIPAAGNNRKLSSQTIHESVIQSSSGSVSSFIDELGYVNDFQYINVGVKFQFLSGVVMEIYKVWQVVQKDQEVSMKLITKDGFMIKAMYNVNKSTDIESLNNGSQLLLKLKTDLRDYIELDIPDRKCMDTRLNHLD

Gene
SRB5
Protein
Mediator of RNA polymerase II transcription subunit 18
Organism
Yarrowia lipolytica (strain CLIB 122 / E 150)
Length
231 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 18 family.
Mass
26.75 kDa
Sequence
MQQISLYAKISNSQLKICLHALASLTGMDPITILQHTMVWAPAQKYTPKILPGQGGQLDQYRIHVTNDNKNEDKEKIISYVQSKDSKEDIHNLANRQWHFQIMEMPEAGKQKTTSQSISSWSVKKGDSFQFLQSLAYKFQYEYWQKGFQFVYGNAVIQLTRIHILDQTTKNIKLLDPSKQWLVKVYIDVGHLTDIEALNKAVKELEKVKTELHGLMNLEIPDRNAFDTRIR