Protein
Serine palmitoyltransferase 2
Organism
Caenorhabditis elegans
Function
Component of the serine palmitoyltransferase (SPT) that catalyzes the first committed step in sphingolipid biosynthesis, which is the condensation of an acyl-CoA species and L-serine. The catalytic core is composed of a heterodimer of sptl-1 and sptl-2 or sptl-1 and sptl-3 (By similarity). Required for the specification of abicobasal polarity and development of the gut lumen.
Similarity
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
Sequence
MSRRTDSLCLDEYLSSELKKRTHILECAWNQEHDDDEEEEEVKVDQGSEETTSSHDIYGDVGKRAPNEFEKIDRLTTIKVYIAWLALFVFAHIREYVTRFGFVKDLSSKENAKMKDFVPLFSDFEAFYQRNCYIKVRDVFERPICSVPGATVDLVDRVSHDGNWTYEYPGTRTNVINVGSYNYLGFAQSAGPCAEQSASSIDREGLSCCTTVHERGRSVSQAKLEKLVAEFLGVEDAICFSMGFATNSMNAPCLVDKHSLIISDKYNHASLILGCRLSGASTKVFEHNDMESLERILRDAIAYGNPKTHRPYKKILIIVEGIYSMEGSICNLPGIIALKKKYQAYLYLDEAHSIGAMGKTGKGVVEYWGCDPKDVDILMGTFTKSFGAAGGYIAGSKRTVDHLRAASPTGYYSSPMSPPIAQQIYTSMSIIMGKDGTKDGAQRIERLARNSHYFRMKLKQNGFIVYGSNDSPVVPMLIYFPTMCGFYGREMLARNIGCVVVSFPATHMTEGRVRFCISAAHTKEQLDEVLETVNLLGSMSRSKFSKRSHLYKNQKIEW