Protein
Transcription elongation factor SPT5
Organism
Caenorhabditis elegans
Function
May function as a component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. DSIF may enhance transcriptional pausing at sites proximal to the promoter, which may in turn facilitate the assembly of an elongation competent RNA polymerase II complex.
Similarity
Belongs to the SPT5 family.
Sequence
MSSDESDAASNKEEDTTLSDDDGSDVEIKNSKKDRKRKLASESEKSGSDDDDDDDDDEDENVTSKKSKKQKRKNKAPSGRDFLAWDVEVDDEDEDDDNDYDDEDDPSMNAMNEREEAERAMKEMELSQRNRDRYKFQNMTEDEVQKYFENKYKGDKNDSQYDDEDSAMDDISKNSHLPSTKDPNLWIVKCRMGEEKLVAMHLMRKCLAVEHTNEPFQIKSVVVKEGLKGMIYIEAFKQSHVMSAIEGFSALNQFTITMVPIKDMVDVLRVVKDIPQLKLGSYVRLKRTMYKDDLAVVDLVDIAQNRVNLKLIPRVDYQKRRGAMRTDADKNYKLKRRPMPKLFDQDTIKEVGGEIVTDGDFLVFEGNHFRRGFLYKYFPINAIQADGVKPTLGELEKFQESSDDLKRELETASLKDTENPFVPGDIVEVKAGELVNLRGKVMTVDGTKVVMMPDQEDLKEAITLNAHELRKYFKEGDHAKVISGRYEGHTGLIVRVKDSTAIVLSDLGMEELKVRVRDLQLCADVTTGVDSLGQFQYHDLVQLDHTGNVGVIVRLEKEHLEVLNMHGVVNRIKPQAIIAKKDVRFAKVLDSQNNSIEAKDLVKVIGGPNAKERETDEDPVGEVLYAFRGTVFVYSRKVTKNGGVLVCKPKQLILQGAKKTTSTPMVSRMASPNPMASPRHSSGGMTPRSPQDGMSSRGSSGGQTPRQGGGGGRGGHFGTANQQKVRRDLTLIGKNVRIIKGPMKGHFGIVRDATEDTVRVELHTQCRTISVDRARVMVVGDTGITAGSGGGSSFYSSSKTPMRDSGKTPMYGSKTPMYGAQTPMYGSMTPAYDGGRTPAYGEGGRTPAYGSKTPAYGDLDEHSSSRTPAYGNDSSRTPAYGSADGARTPAYGSTEGGRTPAYGSMDNSRTPAYDDSGRTPGYESMPSRTPNYDSSSKTPAYPESEHSARTPAYNNDYDIPLSPAYEPDAPEAYDNAPARTPAFVSRTPGYDTYENSSPTYEPDAATKVEEDIGDTSSPTYDSPPHSYVVPTPGAMLNPATPGAYHVDTPGFAAPMTPGSGGAYDQYVAPSPFAGYDSNNYNNADGAIEQIPDHFLAQGVWIVQNLCVQIKDHEGRFNGREAIIKDVTDGKVDVYMPDHKCNLEVDFDQLTPMKPQPGDDARVIFGQDAGHSGQLVSMDGFEAVIRSQEDMSDMRVINIGLCCKMHSET