Function
Plays a role in oocyte axis determination and microtubule organization during oogenesis (PubMed:16540510, PubMed:24019068). Also required for polarized organization of the bristle (PubMed:19917727). Required, with jvl, for activation of the kinase IKKepsilon in the germ line (PubMed:24019068). Also required for localization of IKKepsilon to the distal tip of elongating bristles by acting as an adapter linking IKKepsilon and cytoplasmic dynein (PubMed:26092846). Involved in dendrite pruning in larval sensory neurons during metamorphosis (PubMed:26540204).
Sequence
MEASAAKITPMASSMSASGSTNSPSSEKMNYALQVALQTIKERCIQLQRRVASMEEENQQLREASSRSEGAPRANEIGVTGDVLSLKAQVSELQRQKEQLEEHIGMVSNENRRLWSRLSQISKDQQLNALPSSTDSRAQQNQNLVRSKTFTQHSPNPHLRQKMLSDGIKDLSLEEIALDDFGASSEELGYPYNLQKVEETTSEPDANVDAKRCLDGLQELRREAMKQQQELRSVMTLLENRIALKPCPECAQKTIKKPEMADKSLETDDSLTSELKNYESQHNGHNGTPPSQRINIIQEKIKADAADAMEKTCPMCGKQYSSQVSFNAFREHVEMHFIDDALELESENSIERQFEFVSHAVGDF