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spc2

Gene
SPC2
Protein
Signal peptidase complex subunit SPC2
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
178 amino acids
Function
Nonessential component of the signal peptidase complex (SPC), which catalyzes the cleavage of N-terminal signal sequences of proteins targeted to the endoplasmic reticulum. Signal peptide cleavage occurs during the translocation (cotranslationally or post-translationally) through the translocon pore into the endoplasmic reticulum. SPC2 enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.
Similarity
Belongs to the SPCS2 family.
Mass
20.802 kDa
Sequence
MSSAKPINVYSIPELNQALDEALPSVFARLNYERSYALLDAKLYIGYSIAVVAGLSFFLDKKFERDQIVTYQKLLVGAYFVLSLLFWYFSRFIEKGTVYVGKRRGTKEEIYVKTKFEKNEPLYLVELVQKKKGENSKKELKAKLEVNKVFNESGYLQNDAYFKWFSEQHNVLDTKKNE

Gene
spc2
Protein
Signal peptidase complex subunit spc2
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
167 amino acids
Function
Nonessential component of the signal peptidase complex (SPC), which catalyzes the cleavage of N-terminal signal sequences of proteins targeted to the endoplasmic reticulum. Signal peptide cleavage occurs during the translocation (cotranslationally or post-translationally) through the translocon pore into the endoplasmic reticulum. Spc2 enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site (By similarity).
Similarity
Belongs to the SPCS2 family.
Mass
19.051 kDa
Sequence
MPKYNVSDFKSKFDKELTNHFNKNGYKQSFVFEDIRLLIAIACIIPAGLAFGIEYVYGFGVLKSYLKYLLPLYFLASCLLTFWSSVVKGSTVYVATKKERHIKISADTFLPLKNKPLITTKFTVLKNRNAVQLEWSVPVAHIFEEDGQISSATFEAEISKYLSQIEN