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spas

Gene
spas
Protein
Spastin
Organism
Anopheles gambiae
Length
827 amino acids
Function
ATP-dependent microtubule severing protein. Microtubule severing may promote reorganization of cellular microtubule arrays and the release of microtubules from the microtubule organizing center following nucleation.
Similarity
Belongs to the AAA ATPase family. Spastin subfamily.
Mass
90.536 kDa
Sequence
MVRNKYTLTTAGKSPSKKSRTGSLSKQHDATGDDDGETGTLDGSGSAAGSPVGGGTDAAAKRCDGGSVHKQNLYIISFPVIFVFNVLRSLLYQLFIVFRYVYNFTTKVVYRPVRKECGLEIVINTDQHGHHHHHHHRHSSHSIHSTAAAHQLQQHQQQQQHQYSLLQQEQHGVTEPQQQQQQQHQAAHPLQCSQSGILVNGEGREMSIQRSASGSQVGPGDPLLAKQKHHHRRAFEYISKALKIDEDNEDQKELAIELYRKGILELERGIAVECWGGRGEVWERAQRLHDKMQTNLSMARDRLQFLGMLCVCVSVQRKHLHPTRTTLPYRDVKSKLHTTPTENRMVSFNENCTITTNHHPARGTAASSRPTTAATAPATPSLPIKQTASEASGRKLTVGYKRPGNLGVMNKSQTLPRSMGGTRTTPTGTGGAGGIAGGLGNGGTYGGSIVGGGAGMPKIVPKPAATPPAIRRQFSVSIPIPGSSPVRKASNGYGSKNTPPPRSKTPLAGQQPQQPQQQQQQQPQISVKGVEPKLVQIIMDEIVEGGAKVQWQDIAGQEVAKQALQEMVILPSVRPELFTGLRTPAKGLLLFGPPGNGKTLLARAVATECSATFFSISAATLTSKYVGDGEKLVRALFAVARELQPSIIFIDEVDSVLSERSSNEHEATRRLKTEFLVQFDGLPANSEADRIVVMAATNRPQELDEAALRRFPKRVYVTLPDRDTRELLLRRLLQKQGSPLSDADLAHLAQLTEGYSGSDLTALARDAALEPIRELNVEEVKNMDPTKLRSIRESDFHNSLKRIRRSVAPQSLAAYEKWLQDFGDVTL

Gene
spas
Protein
Spastin
Organism
Drosophila persimilis
Length
788 amino acids
Function
ATP-dependent microtubule severing protein. Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle. Regulates microtubule stability in the neuromuscular junction synapse. Involved in lipid metabolism by regulating the size and distribution of lipid droplets. Involved in axon regeneration by regulating microtubule severing.
Similarity
Belongs to the AAA ATPase family. Spastin subfamily.
Mass
86.107 kDa
Sequence
MVRTKNQSSSSSASSSSHKSPIKSHGGSGSAAAGTAGHPVSRSSSSHRTSIDDRKSATNVSSSSNRRTTPGSSPDGDGDDDTTTTDDLTPTSTSAPRSAGGPSSVHKQNLYVVSFPIIFLFNVLRSLIYQLFCIFRYLYGASTKVIYRPHRRDCNIEIVVQNNSNNKDQKHQQLTSSQSLNYPLEVTSGEAASEQQVQQPLPQQRYRALQPLEMAGANRSGSGYSPGPGDPLLAKQKHHHRRAFEYISKALKIDEENEGHKELAIELYRKGIKELEDGIAVDCWSGRGDVWDRAQRLHDKMQTNLSMARDRLHFLALREEDFQMHRLSLKEKQKANESREQQQKPQKAREAADKPMLTNLTNDPAKLKTRSSGYGPKNGLTTPRIFATATTPTSSSSLASGRKLTIGTKRPGNLAVAANKSQTLPRNLGSKTSVGAVRQPGKTAATPPAVRRQFSSGRNTPPQRSRTPINNNGASGSGSGASTPVVTVKGVEQKLVQLILDEIVEGGAKVEWTDIAGQEVAKQALQEMVILPSVRPELFTGLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDGEKLVRALFAVARHLQPSIIFIDEVDSLLSERSSGEHEASRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALRRFTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTDALRRLSKITDGYSGSDLTALAKDAALEPIRELNVEQVKCLDINAMRHITEKDFHNSLKRIRRSVAPQSLSLYEKWSSDYGDITI

Gene
spas
Protein
Spastin
Organism
Drosophila pseudoobscura pseudoobscura
Length
788 amino acids
Function
ATP-dependent microtubule severing protein. Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle. Regulates microtubule stability in the neuromuscular junction synapse. Involved in lipid metabolism by regulating the size and distribution of lipid droplets. Involved in axon regeneration by regulating microtubule severing.
Similarity
Belongs to the AAA ATPase family. Spastin subfamily.
Mass
86.084 kDa
Sequence
MVRTKNQSSSSSASSSSHKSPIKSHGGSGSAAAGTAGHPVSRSSSSHRTSIDDRKSATNVSSSSNRRTTPGSSPDGDGDDDTTTTDDLTPTSTSAPRSAGGPSSVHKQNLYVVSFPIIFLFNVLRSLIYQLFCIFRYLYGASTKVIYRPHRRDCNIEIVVQNNSNNKDQKHQQLTSSQSLNYPLEVTSGEAASEQQVQQPLPQQRYRALQPLEMAGANRSGSGYSPGPGDPLLAKQKHHHRRAFEYISKALKIDEENEGHKELAIELYRKGIKELEDGIAVDCWSGRGDVWDRAQRLHDKMQTNLSMARDRLHFLALREEDFQMHRLSLKEEQKPNPSREQHQKPQKAREAADKPMLTNLTNDPVKLKTRSSGYGPKNGLTTPRISATATTPTSSSSLASGRKLTIGTKRPGNLAVAANKSQTLPRNLGSKTSVGAVRQPGKTAATPPAVRRQFSSGRNTPPQRSRTPINNNGASGSGSGASTPVVTVKGVEQKLVQLILDEIVEGGAKVEWTDIAGQEVAKQALQEMVILPSVRPELFTGLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDGEKLVRALFAVARHLQPSIIFIDEVDSLLSERSSGEHEASRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALRRFTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTDALRRLSKITDGYSGSDLTALAKDAALEPIRELNVEQVKCLDINAMRHITEKDFHNSLKRIRRSVAQQSLSSYEKWSSDYGDITI

Gene
spas
Protein
Spastin
Organism
Drosophila grimshawi
Length
782 amino acids
Function
ATP-dependent microtubule severing protein. Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle. Regulates microtubule stability in the neuromuscular junction synapse. Involved in lipid metabolism by regulating the size and distribution of lipid droplets. Involved in axon regeneration by regulating microtubule severing.
Similarity
Belongs to the AAA ATPase family. Spastin subfamily.
Mass
85.732 kDa
Sequence
MVRTKNQSSSSSASSSTKSPVKISGGTTNRSRSCSDALIDDGNSKSSSKPTSNNRQRTTTNNNTTAITTTPGSSPDNDDDDTTTTDADLTPTSGNAPRGGNSSVHKQNLYVVSFPIIFLFNVLRSLIYQLFCIFRYLYGASTKVIYRSPNRRDCNIEIVVQNSKEQQQQHQHQQAIIHCPLERRGNISGIEQTLAQALPQRQRAIQPLEMAGNRAGGNYSPGPGDPLLAKQKHHHRRAFEYISKALKIDEENEGHKELAIELYRKGIKELEDGIAVDCWSGRGDVWDRAQRLHDKMQTNLSMARDRLHFLALREEDLQLQRLSLKEQQQKKKSPQQQPQQQQQHTFKQPMLVGQTNSSGGSGSTKVPLRSSGYGLKPSATNISRAMPAASGRKLTIGNKRPGNLPVVNKSQTLPRNLGSKTSSTSVGAALQRQPGKTAATPPAVRRQFSSGRNTPPQRSRTPINNNAAGGSGSGASTPMVSVKGVEQKLVQLILDEIVEGGAKVEWTDIAGQDVAKQALQEMVILPSVRPELFTGLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSERSSNEHEASRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALRRFTKRVYVSLPDVQTRELLLNRLLQKQGSPLDSDALGRLAKITEGYSGSDLTALAKDAALEPIRELNVEQVKCLDISAMRQITEKDFHNSLKRIRRSVAPQSLNSYEKWSQDYGDITI

Gene
spas
Protein
Spastin
Organism
Drosophila willistoni
Length
777 amino acids
Function
ATP-dependent microtubule severing protein. Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle. Regulates microtubule stability in the neuromuscular junction synapse. Involved in lipid metabolism by regulating the size and distribution of lipid droplets. Involved in axon regeneration by regulating microtubule severing.
Similarity
Belongs to the AAA ATPase family. Spastin subfamily.
Mass
85.093 kDa
Sequence
MVRTKSSSSSASSSSQKSPIKSNNGAGGGGSSSSHRQSHRTSIDERKSSSHAHSNNSNVSSSSRRAATATSGSSSPEGDDDTTTDDLTPTGSSPRSCNGRGHSSVHKQNLYVVSFPIIFLFNVLRSLIYQLFCIFRYLYGASTKVLYRPHRRDCNIEIVVQNSKEQQLQLQQHQHNQTLSYSLETGGVSGGSGGEQQVQVQPQRIRALQPLEMATNRPGGGYSPGPGDPLLAKQKHHHRRAFEYISKALKIDEENEGHKELAIELYRKGIKELEDGIAVDCWNGRGDVWDRAQRLHDKMQTNLSMARDRLHFLALREEDLQMQRLSLKEKQPAPKQPQRSQTKDPVKQPMLTSLNADPVKMKVRSSGYGPKQNGTSSSRPAPSGQTATGASGRKLTVGTKRPGNLPVTNKSQTLPRNLGSKTTVGAVQRQPAKTAATPPAVRRQFSSGRNTPPQRSRTPINNNASSGSGASTPMVSVKGVEQKLVQLILDEIVEGGAKVEWTDIAGQDVAKQALQEMVILPSVRPELFTGLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSERSSNEHEASRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALRRFTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTEALRRLAKITEGYSGSDLTALAKDAALEPIRELNVEQVKCLDISAMRPITEKDFHNSLKRIRRSVAPQSLNSYEKWSQDYGDITI

Gene
spas
Protein
Spastin
Organism
Drosophila ananassae
Length
770 amino acids
Function
ATP-dependent microtubule severing protein. Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle. Regulates microtubule stability in the neuromuscular junction synapse. Involved in lipid metabolism by regulating the size and distribution of lipid droplets. Involved in axon regeneration by regulating microtubule severing.
Similarity
Belongs to the AAA ATPase family. Spastin subfamily.
Mass
83.796 kDa
Sequence
MVRTKNQSSSSSASSSTKSPIKSGSAGSGSAAGGNSASGSRQSTHRSSSASNVASAAAAAVASSNRTRTSPGSSPDGDDDTTTTDDLTPTSCSPRSGHHHHGHPYGGSSVHKQNLYVVSFPIIFLFNVLRSLIYQLFCIFRYLYGASTKVIYRPHRRDCNIEIVVQNSKDQQQQHQSQPLSYPLELSEGGNPEQQLPSQTQRYRAIQPLEMASNRPGGGYSPGPGDPLLAKQKHHHRRAFEYISKALKIDEENEGHKELAIELYRKGIKELEDGIAVDCWSGRGDVWDRAQRLHDKMQTNLSMARDRLHFLALREEDLRMQRLSLKEKQQKTLPQSDYKALKSREPMLAGMTNDPLKPRVRSSGYGPKASTSAQAAAATAASGRKLTIGTKRPGNLAVANKSQTLPRNLGSKTSVGAVQRQPAKTAATPPAVRRQFSSGRNTPPLRSRTPINNNGPSTSGSGASTPVVSVKGVEPKLVQLILDEIVEGGAKVEWSDIAGQEVAKQALQEMVILPSVRPELFTGLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSERSSNEHEASRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALRRFTKRVYVSLPDEQTRELLLSRLLQKQGSPLDTEALRRLAKTTDGYSGSDLTALAKDAALEPIRELNVEQVKCLDISAMRAITESDFHSSLKRIRRSVAPQSLNSYEKWSQDYGDITI

Gene
spas
Protein
Spastin
Organism
Drosophila virilis
Length
769 amino acids
Function
ATP-dependent microtubule severing protein. Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle. Regulates microtubule stability in the neuromuscular junction synapse. Involved in lipid metabolism by regulating the size and distribution of lipid droplets. Involved in axon regeneration by regulating microtubule severing.
Similarity
Belongs to the AAA ATPase family. Spastin subfamily.
Mass
83.232 kDa
Sequence
MVRTKNQSSSSSASSSTKSPVKISGGGGGGGGSSSSTNRSRSCSEALIDDGKSSSKLSSNRQRTTTTITTTTTTPGSSPDDDTTDADLTPTSGNVPRGGQSVHKQNLYVVSFPIIFLFNVLRSLIYQLFCIFRYLYGASTKVIYRSPHRRDCNIEIVVQNSKEQQAIICPLEGSGVNIEQAQILPQRQRALQTLEMAASRGGTGAGGYSPGPGDPLLAKQKHHHRRAFEYISKALKIDEENEGHKELAIELYRKGIKELEDGIAVDCWSGRGDVWDRAQRLHEKMQTNLSMARDRLHFLALREEDLQMQRLSLKEQPKKQLPHKFKQPMLVGQTTTSSGSSSSSRASAEPPKITLRSSGYGPKTGGATTSKAVPAASGRKLTIGNKRPGNLAVANKSQTLPRNLGSKTTSTSVGAALQRQPGKTAATPPAVRRQFSSGRNTPPQRSRTPINNNAASGSGSGASTPLISVKGVEQKLVQLILDEIVEGGAKVEWSDIAGQDVAKQALQEMVILPSVRPELFTGLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSERSSNEHEASRRLKTEFLVEFDGLPGNPEGDRIVVLAATNRPQELDEAALRRFTKRVYVSLPGVQTRELLLSRLLQKQGSPLDTEALARLAKITDGYSGSDLTALAKDAALEPIRELNVEQVKCLDISAMRPITEKDFHNSLKRIRRSVAPQSLNSYEKWSQDYGDITI

Gene
spas
Protein
Spastin
Organism
Drosophila mojavensis
Length
765 amino acids
Function
ATP-dependent microtubule severing protein. Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle. Regulates microtubule stability in the neuromuscular junction synapse. Involved in lipid metabolism by regulating the size and distribution of lipid droplets. Involved in axon regeneration by regulating microtubule severing.
Similarity
Belongs to the AAA ATPase family. Spastin subfamily.
Mass
83.294 kDa
Sequence
MVRTKNQSSSSSASSSTKSPVKISGGGSSGANRSRSCSEALIDDGKTSSKLSSNRQRATITTTTTSTTPGSSPDDDTTDADLTPTSGYGPRGGTSVHKQNLYVVSFPIIFLFNVLRSLIYQLFCIFRYLYCASTKVIYRSPHRRDCNIEIVVQNSKEQQSIICPLERNTSDGIEKAQQLLPQRQRALLPLEMATNRGGSGGYSPGPGDPLLAKQKHHHRRAFEYISKALKIDEENEGHKELAIELYRKGIKELEDGIAVDCWSGRGDVWDRAQRLHEKMQTNLSMARDRLHFLALREEDLQMQRLSLMDPPKNKQQVTSKFKQPMLVGQTNSKAAAVEPSKITMRSSGYGPKPVSGTGSSAGTSKALQAASGRKLTIGNKRPGNLAVANKSQTLPRNLGSKTTSTSVGAALQRQPGKTAATPPAVRRQFSSGRNTPPQRSRTPINNNAASGSGSGSGASTPMISVKGVEQKLVQLIMDEIVEGGAKVEWTDIAGQDVAKQALQEMVILPSVRPELFTGLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDGEKLVRALFAVARHLQPSIIFIDEVDSLLSERSSNEHEASRRLKTEFLVEFDGLPGNPEGDRIVVLAATNRPQELDEAALRRFTKRVYVSLPEVQTRELLLSRLLQKQGSPLDTEALARLAKITDGYSGSDLTALAKDAALEPIRELNVEQVKCLDISAMRPITEKDFHNSLKRIRRSVAPQSLNSYEKWSQDYGDITI

Gene
spas
Protein
Spastin
Organism
Drosophila erecta
Length
758 amino acids
Function
ATP-dependent microtubule severing protein. Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle. Regulates microtubule stability in the neuromuscular junction synapse. Involved in lipid metabolism by regulating the size and distribution of lipid droplets. Involved in axon regeneration by regulating microtubule severing.
Similarity
Belongs to the AAA ATPase family. Spastin subfamily.
Mass
82.629 kDa
Sequence
MVRTKNQSSSSSASSSSTKSPIKSSSGAGSSGGGVGGRQSTHRSSSASNVAAVVAGGSSAAGGGSSSNRRSPGSSPDGDDDTTTTDDLTPTTCSPRSGHHHTYGGYSSSVHKQNLYVVSFPIIFLFNVLRSLIYQLFCIFRYLYGASTKVIYRPHRRDCNIEIVVQNSSKEQQQSLNHPSELSREGDGQEQQLSNQPQRFRPIQPLEMAANRPGGGYSPGPGDPLLAKQKHHHRRAFEYISKALKIDEENEGHKELAIELYRKGIKELEDGIAVDCWSGRGDVWDRAQRLHDKMQTNLSMARDRLHFLALREQDLQMQRLSLKEKPKVQAPSKPQKTREPMLAGMTNEPMKLRVRSSGYGPKATTSAQPTASGRKLTIGSKRPVNLAVANKSQTLPRNLGSKTSVGAVQRQPAKTAATPPAVRRQFSSGRNTPPQRSRTPINNNGPSGSGASTPVVSVKGVEQKLVQLILDEIVEGGAKVEWTDIAGQDVAKQALQEMVILPSVRPELFTGLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSERSSSEHEASRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALRRFTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTEALRRLAKITDGYSGSDLTALAKDAALEPIRELNVEQVKCLDISAMRAITEQDFHSSLKRIRRSVAPQSLNSYEKWSQDYGDITI

Gene
spas
Protein
Spastin
Organism
Drosophila melanogaster
Length
758 amino acids
Function
ATP-dependent microtubule severing protein. Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle (PubMed:15242610, PubMed:15562320, PubMed:15823537, PubMed:16276413, PubMed:17452528, PubMed:25875445, PubMed:18202664, PubMed:19341724). Regulates microtubule stability in the neuromuscular junction synapse (PubMed:15242610, PubMed:15562320, PubMed:19341724). Involved in lipid metabolism by regulating the size and distribution of lipid droplets (PubMed:25875445). Involved in axon regeneration by regulating microtubule severing (PubMed:23122959).
Similarity
Belongs to the AAA ATPase family. Spastin subfamily.
Mass
82.749 kDa
Sequence
MVRTKNQSSSSSASSSSTKSPIKSSSGAGSSGGGLGGRQSTHRSSSASNVAAVVAGGSSAAGGGSSSNRRSPGSSPDGDDDTTTTDDLTPTTCSPRSGHHHSYGGYSSSVHKQNLYVVSFPIIFLFNVLRSLIYQLFCIFRYLYGASTKVIYRPHRRDCNIEIVVQNSSKEQQQSLNHPSELNREGDGQEQQLSNQPQRFRPIQPLEMAANRPGGGYSPGPGDPLLAKQKHHHRRAFEYISKALKIDEENEGHKELAIELYRKGIKELEDGIAVDCWSGRGDVWDRAQRLHDKMQTNLSMARDRLHFLALREQDLQMQRLSLKEKQKEEAQSKPQKTREPMLAGMTNEPMKLRVRSSGYGPKATTSAQPTASGRKLTIGSKRPVNLAVANKSQTLPRNLGSKTSVGAVQRQPAKTAATPPAVRRQFSSGRNTPPQRSRTPINNNGPSGSGASTPVVSVKGVEQKLVQLILDEIVEGGAKVEWTDIAGQDVAKQALQEMVILPSVRPELFTGLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSERSSSEHEASRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALRRFTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTEALRRLAKITDGYSGSDLTALAKDAALEPIRELNVEQVKCLDISAMRAITEQDFHSSLKRIRRSVAPQSLNSYEKWSQDYGDITI

Gene
spas
Protein
Spastin
Organism
Drosophila sechellia
Length
758 amino acids
Function
ATP-dependent microtubule severing protein. Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle. Regulates microtubule stability in the neuromuscular junction synapse. Involved in lipid metabolism by regulating the size and distribution of lipid droplets. Involved in axon regeneration by regulating microtubule severing.
Similarity
Belongs to the AAA ATPase family. Spastin subfamily.
Mass
82.763 kDa
Sequence
MVRTKNQSSSSSASSSSTKSPIKSSSGAGSSGGGVGGRQSTHRSSSASNVAAVVAGGSSAAGGGSSSNRRSPGSSPDGDDDTTTTDDLTPTTCSPRSGHHHSYGGYSSSVHKQNLYVVSFPIIFLFNVLRSLIYQLFCIFRYLYGASTKVIYRPHRRDCNIEIVVQNSSKEQQQSLNHPSELNREGDGQEQQLSNQPQRFRPIQPLEMAANRPGGGYSPGPGDPLLAKQKHHHRRAFEYISKALKIDEENEGHKELAIELYRKGIKELEDGIAVDCWSGRGDVWDRAQRLHDKMQTNLSMARDRLHFLALREQDLQMQRLSLKEKQKEEARSKPQKTREPMLAGMTNEPMKLRVRSSGYGPKATTSAQPTASGRKLTIGSKRPVNLAVANKSQTLPRNLGSKTSVGAVQRQPAKTAATPPAVRRQFSSGRNTPPQRSRTPINNNGPSGSGASTPVVSVKGVEQKLVQLILDEIVEGGAKVEWTDIAGQDVAKQALQEMVILPSVRPELFTGLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSERSSSEHEASRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALRRFTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTEALRRLAKITDGYSGSDLTALAKDAALEPIRELNVEQVKCLDISAMRAITEQDFHSSLKRIRRSVAPQSLNSYEKWSQDYGDITI

Gene
spas
Protein
Spastin
Organism
Drosophila simulans
Length
758 amino acids
Function
ATP-dependent microtubule severing protein. Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle. Regulates microtubule stability in the neuromuscular junction synapse. Involved in lipid metabolism by regulating the size and distribution of lipid droplets. Involved in axon regeneration by regulating microtubule severing.
Similarity
Belongs to the AAA ATPase family. Spastin subfamily.
Mass
82.818 kDa
Sequence
MVRTKNQSSSSSASSSSTKSPIKSSSGAGSSGGGVGGRQSTHRSSSASNVAAVVAGGSSAAGGGSSSNRRSPGSSPDGDDDTTTTDDLTPTTCSPRSGHHHSYGGYSSSVHKQNLYVVSFPIIFLFNVLRSLIYQLFCIFRYLYGASTKVIYRPHRRDCNIEIVVQNSSKEQQQSLNHPSELNREGDGQEQQLSNQPQRFRPIQPLEMAANRPGGGYSPGPGDPLLAKQKHHHRRAFEYISKALKIDEENEGHKELAIELYRKGIKELEDGIAVDCWSGRGDVWDRAQRLHDKMQTNLSMARDRLHFLALREQDLQMQRLSLKEKQKEEARSKPQKSREPMLAGMTNEPMKLRVRSSGYGPKATTSAQPTASGRKLTIGSKRPVNLAVANKSQTLPRNLGSKTSVGAVQRQPAKTAATPPAVRRQFSSGRNTPPQRSRTPINNNGPSGSGASTPVVSVKGVEQKLVQLILDEIVEGGAKVEWTDIAGQDVAKQALQEMVILPSVRPELFTGLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSERSSSEHEASRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALRRFTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTEALRRLAKITDGYSGSDLTARPKDAALEPIRELNVEQVKCLDISAMRAITEQDFHSSLKRIRRSVAPQSLNSYEKWSQDYGDITI

Gene
spas
Protein
Spastin
Organism
Drosophila yakuba
Length
758 amino acids
Function
ATP-dependent microtubule severing protein. Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle. Regulates microtubule stability in the neuromuscular junction synapse. Involved in lipid metabolism by regulating the size and distribution of lipid droplets. Involved in axon regeneration by regulating microtubule severing.
Similarity
Belongs to the AAA ATPase family. Spastin subfamily.
Mass
82.761 kDa
Sequence
MVRTKNQSSSSSASSSSTKSPIKSSSATGSSGGGVGGRQSTHRSSSASNVAAVVAGGSSAAGGGSSSNRRSPGSSPDGDDDTTTTDDLTPTTCSPRSGHHHTYGGYSSSVHKQNLYVVSFPIIFLFNVLRSLIYQLFCIFRYLYGASTKVIYRPHRRDCNIEIVVQNSSKEQQQSLNHPSELNRDSDGQEQQLSNQPQRFRPIQPLEMAANRPGGGYSPGPGDPLLAKQKHHHRRAFEYISKALKIDEENEGHKELAIELYRKGIKELEDGIAVDCWSGRGDVWDRAQRLHDKMQTNLSMARDRLHFLALREQDLQMQRLSLKEKQNEQAPSKPQRTREPMLAGMTNEPMKLRVRSSGYGPKATTGAQPTASGRKLTIGSKRPVNLAVANKSQTLPRNLGSKTSVGAVQRQPAKTAATPPAVRRQFSSGRNTPPQRSRTPINNNGPSGSGASTPVVSVKGVEQKLVQLILDEIVEGGAKVEWTDIAGQDVAKQALQEMVILPSVRPELFTGLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSERSSSEHEASRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALRRFTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTEALRRLAKITDGYSGSDLTALAKDAALEPIRELNVEQVKCLDISAMRAITEQDFHSSLKRIRRSVAPQSLNSYEKWSQDYGDITI

Gene
spas
Protein
Spastin
Organism
Ixodes scapularis
Length
648 amino acids
Function
ATP-dependent microtubule severing protein. Microtubule severing may promote reorganization of cellular microtubule arrays and the release of microtubules from the microtubule organizing center following nucleation.
Similarity
Belongs to the AAA ATPase family. Spastin subfamily.
Mass
72.474 kDa
Sequence
MASTVALLRDSSDDRENFDDGETDCVQVGRKRKLTVFFYPLLLVFWLLRWVFYQFFLVLCFVCRGFVPRRHLATAETTTTMATAEEPDANLLIRQKQHHKKAFDFISKALKYDEENEDFKEMSIDLYRKGIEELQKGIAIDFSKGQGTTWERAHRLSDKMKVNLEMARDRLDFLESMVKIEHLGDHLPWHGGVAPAQRGQRRRAWQKAAPSAPSEPGTGPSWLKMAENGPAKGGPCPTSPRLQRSNTGVTLRRQQQQQLGGVSTVSRSQTLPRNSVPCPRMSARSPSRKAGNNEAVPTPNTARRRASQPQVPPVHPRGRQPTTRGGAAHRGGPPTVSQRSLLSSRVPPLKGVDSRLAHLILDEVVDGAPPVLFSDIAGQEVAKQALSEMVILPTDRPELFTGLRAPPKGLLLFGPPGNGKTMLAKAVAHESNSTFLNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLSERKDNEHEATRRLKTEFLVEFDGLHTGSEERVLVMGATNRPQELDDAALRRFTKRVYVTLPDHNTRVILLEKLLKKHNNPLSADKLKYLARLTEGYSGSDLTALAKDAALGPIRELNPEQVRCVDPKKMRNISLQDFLDSLKKVRRSVTPQSLDFFDRWNREFGDITV

Gene
spaS
Protein
Surface presentation of antigens protein SpaS
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Length
356 amino acids
Function
Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells.
Similarity
Belongs to the type III secretion exporter family.
Mass
40.093 kDa
Sequence
MSSNKTEKPTKKRLEDSAKKGQSFKSKDLIIACLTLGGIAYLVSYGSFNEFMGIIKIIIADNFDQSMADYSLAVFGIGLKYLIPFMLLCLVCSALPALLQAGFVLATEALKPNLSALNPVEGAKKLFSMRTVKDTVKTLLYLSSFVVAAIICWKKYKVEIFSQLNGNIVGIAVIWRELLLALVLTCLACALIVLLLDAIAEYFLTMKDMKMDKEEVKREMKEQEGNPEVKSKRREVHMEILSEQVKSDIENSRLIVANPTHITIGIYFKPELMPIPMISVYETNQRALAVRAYAEKVGVPVIVDIKLARSLFKTHRRYDLVSLEEIDEVLRLLVWLEEVENAGKDVIQPQENEVRH

Gene
spaS
Protein
Surface presentation of antigens protein SpaS
Organism
Shigella flexneri
Length
342 amino acids
Function
Required for surface presentation of invasion plasmid antigens. Could play a role in preserving the translocation competence of the ipa antigens. Required for invasion and for secretion of the three ipa proteins.
Similarity
Belongs to the type III secretion exporter family.
Mass
39.852 kDa
Sequence
MANKTEKPTPKKLKDAAKKGQSFKFKDLTTVVIILVGTFTIISFFSLSDVMLLYRYVIINDFEINEGKYFFAVVIVFFKIIGFPLFFCVLSAVLPTLVQTKFVLATKAIKIDFSVLNPVKGLKKIFSIKTIKEFFKSILLLIILALTTYFFWINDRKIIFSQVFSSVDGLYLIWGRLFKDIILFFLAFSILVIILDFVIEFILYMKDMMMDKQEIKREYIEQEGHFETKSRRRELHIEILSEQTKSDIRNSKLVVMNPTHIAIGIYFNPEIAPAPFISLIETNQCALAVRKYANEVGIPTVRDVKLARKLYKTHTKYSFVDFEHLDEVLRLIVWLEQVENTH

Gene
spaS
Protein
Surface presentation of antigens protein SpaS
Organism
Shigella sonnei
Length
342 amino acids
Function
Required for surface presentation of invasion plasmid antigens. Could play a role in preserving the translocation competence of the ipa antigens. Required for invasion and for secretion of the three ipa proteins (By similarity).
Similarity
Belongs to the type III secretion exporter family.
Mass
39.852 kDa
Sequence
MANKTEKPTPKKLKDAAKKGQSFKFKDLTTVVIILVGTFTIISFFSLSDVMLLYRYVIINDFEINEGKYFFAVVIVFFKIIGFPLFFCVLSAVLPTLVQTKFVLATKAIKIDFSVLNPVKGLKKIFSIKTIKEFFKSILLLIILALTTYFFWINDRKIIFSQVFSSVDGLYLIWGRLFKDIILFFLAFSILVIILDFVIEFILYMKDMMMDKQEIKREYIEQEGHFETKSRRRELHIEILSEQTKSDIRNSKLVVMNPTHIAIGIYFNPEIAPAPFISLIETNQCALAVRKYANEVGIPTVRDVKLARKLYKTHTKYSFVDFEHLDEVLRLIVWLEQVENTH

Gene
spaS
Protein
Lantibiotic subtilin
Organism
Bacillus subtilis
Length
56 amino acids
Function
Lanthionine-containing peptide antibiotic (lantibiotic) active on Gram-positive bacteria. The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores.
Similarity
Belongs to the type A lantibiotic family.
Mass
6.218 kDa
Sequence
MSKFDDFDLDVVKVSKQDSKITPQWKSESLCTPGCVTGALQTCFLQTLTCNCKISK