Protein
Transcription factor Sp8
Function
Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos.
Similarity
Belongs to the Sp1 C2H2-type zinc-finger protein family.
Sequence
MLAATCNKIGSPSPSPSSISDNSSSFGKGFHPWKRATASSCSLGSSLSSFTRNGGGLSDSFGTNTSTGSSAFSLTSGTSSNSHFGNDYSVFQTSVSNNSQEPSHQPMFISKVHTSVDSLQSIYPRMSVAHPYESWFKSSHPGIPTGDVGTTGASAWWDVGAGWIDVQNPNGAALQTSLHSGGLQTSLHSPLGGYNSDYSSLSHSAFSTSASPHLLTTGQHLMDGFKPVLSSYPDSSPSPLGGAGGSMLTGGPTASLAGSPRSSARRYSGRATCDCPNCQEAERLGPAGASLRRKGLHSCHIPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELQRHLRTHTGEKRFACPVCNKRFMRSDHLSKHVKTHSAGGSSGSGSGASGGKRGSDTDSEHSVPGSPSCHSPDLLQAPESVPTTGMNGRASSLD