smg-8

Gene

smg-8

Protein

Protein smg-8

Organism

Caenorhabditis elegans

Length

873 amino acids

Function

Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Probable component of kinase complex containing smg-1 and recruited to stalled ribosomes.

Similarity

Belongs to the SMG8 family.

Mass

99.97 kDa

Sequence

MDIAKWVEHARTCYSTQLDTKIKVIGVIGKDYPDHGKGDNINCYLRENVFPVAATEDETCTIRGHFSEDDQILFLVMNGVDDVANIRKCLKSNPKSNYFDAMAESECQQIRMLHFLFISCHFIIIFEQTSRIDLELMRFLKKVNSARIQLRKKINQRLVASDLRDVSFNNRILSSAESEGRMVVPRLLIAFQRNNIRPDVNPGKKLQRELYEKLEKNLDNQFSDILKLYDLIDCGASSLCQLNETIPVVHLLNPKIVKRDIIGEMFEILMADAENTKISGNAGTLPSNNSFVKFLEDNFRSEKNEISLENVIELMNCLQCVLDGDLEEKHEKTAIQTFIKRIQNDHMEEARRLYTNAQRPGERRGADRFKDSEKPVKIRSKEEHLMRFNEATHYIDSVVGVNSREALSQLQAQCNEMWQSDMRACESVSMMGRSCVRKIHPTFGDQTAPEHRWTAHDASNTMISTCVCGRKQLIRPEPFSVKEANSDFYDHPDFKCCRRLWRYQFQLYQEDSEEKDDIMWADRESNSLRAAKKMAQREDELAEEDTDLDIPESLLDPDSTSPSDEDDVRVRTMSSSESSSQESDAYLRPTSRRDESMASKTERELTIDHVKRMQKLELAGKSEDFLITVPNSMTTGKLPIFPSWHLTSLGDSSIYSHGAGLKNQPNFKIGGDYLSPVVVLLDVNFDVWNRDLNKIRSEDFSRKCGKDNKDDSARVKLFVGFEYECSRGHRFFVDYNGEPLIYSKGSNVIRESAHRSSLGNVLQADLPIRRPCTCRKLPLQSAQLQKVHVVTPKAPVHITIDPKVLIPTHEGVYGTGQEPLELHHSKYYILHLPTVYSGPSGAWMPGEFNPEKQGVWMGGALKVAYKPVMSFKW

Protein

Protein smg-8: smg-8

Gene

smg-8

Protein

Protein smg-8

Organism

Caenorhabditis briggsae

Length

871 amino acids

Function

Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Probable component of kinase complex containing smg-1 and recruited to stalled ribosomes (By similarity).

Similarity

Belongs to the SMG8 family.

Mass

100.054 kDa

Sequence

MNISEWIEQSRSVFKAQLDTKIKIIGIIGKDYPDHGKGDNINCYLRENVFPVATSDNETCTIFAHFSEDEQLLFLVLNGVDDVANLRKCMESESKNYFEAMAESESQQMRLLHFLFISCHFIVIFEQTSRIDLEFIRFLKKVNTLRSLNRRKVSQRLRDVDFDFDSDGRLTVPYVLMAFQRNNIRTDTNITKKRELYEKLEKNLDHQLTDILKLYDLTGSGNSALCQLSESLQVVHLLNPDSVKRDIITEMFDIFMAEAENGNVARVAANHKLTSNNAFVRFLEDRFRAEKNEISLNIAIDMLEALQFVLDGSLEEKPESLRSQTQTFIKRIQSDHMEEARRLYTNETRPVSGERRGGGFRITEQETMDPSVKIRSKQEHLIRFNEATCYIETVVGINQQEILSQVQTQCNDMWQSDLRACESISMMGHPCVKKVHPTYGDQTVPEARWTAHDASNTLVSTCVCGNKQLVRQEPFTLKEANFDFYEHPDFNCCKGLWRYQFQLYQEDTEEKDDIMWADRESNSLRAAKKMAQREDELAVELDDMELPESLQQSYTSSEDSSEDDDDFAIQTASSEDSLSGSDSYARPGSRRDEFESSKTARDMAVYFAKRIQKLEKLEKMDDFLMGVPNTLTIGKLPMFPSFFLTSLGESNLYKHGAGLKNQPNFKLGGEYLTPAVVFLDVDLDVWCRDLVKFRTDDYTRRGTKDLKDDMPRVKLFVGFEYECSRGHRFFVDHNGEPLIYPRNVNVLKESSARASLGNILNADLPLRRPCTCRKPPLKSAQLQKIHVVTPKAPVKITIDPKILVPGHEGTYGTGQEPLELHHSKYYILHLPVVYSGPSGTWMPGEYNSERMGTLKGGSIKVVYKPVMPFRW

Protein

Protein smg-8: smg-8