Protein
Sphingomyelinase C
Organism
Listeria ivanovii
Function
Virulence factor that promotes intracellular proliferation by mediating the disruption of the phagocytic vacuole and the release of bacteria into the host cell cytosol. May act in concert with the phospholipases PlcA and PlcB and the hemolysin hly to mediate efficient escape from the vacuole.
Similarity
Belongs to the neutral sphingomyelinase family.
Sequence
MEKFKIIKTIPKICGAFIFLLFFTFLFGHYGELKTQASDEYPGNFKITSHNVYLFSRNIYPNWGQMHRADLIAQADYMKNNDVVILNEAFDTSASHRLLNNLREMYPHQTPVIGRSKHGWDKTEGNYSNFALEDGGVAVVSQWPIVEKSQHIFQRGGGADRLSNKGFAYVKIMKNGKPYHIIGTHTPADDSLISKDTSRAIRAEQMQEIQTFIAKKNIPKDEIIFIGGDLNVNYGTDEYHDMFKLLNVSSPANFNGQMATWDPTTNSMLKESYPKAAPEYLDYIFVENGHARPHSWHNKVLHTKSPQWSVKSWFKTYTYQDFSDHYPVVGFTDNN