smc6

Structural maintenance of chromosomes protein 6

1185 amino acids

Core component of the smc5-smc6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the smc1-smc3 cohesin complex to double-strand breaks (By similarity).

Belongs to the SMC family. SMC6 subfamily.

136.329 kDa

MSKRKLGHDGNSHELDEEEEEEEEDDDDELIHSTQDQDRPHKQQRVENGKQMTPTKQHQQQQQQQPISNGRLKKLKAQSSDEESGSSEDDDEDVEDVDSSGSDSGSSDDDDDDDDDDDDDDGNSEDEREAVRREQQLKSGVTEPEAGIIESITLENFMCHRHFKLDFCSNVNFIAGENGSGKSAVLIALIVCLGAKAGFTNRGSKLSDLVKAETNTAVITVKLRNQGQEAFKPEKYGKSVIIERRISRTGSSGYKVKDYNGKTVSDKFNDVSLILEQFNIQIDNPMSILTQDTSRQFLNSAGPQDKYKSFLMATQLDKMTKDYTTIREHIDKIKDMLSQKVVVIQELEKKVREYNKEYKDLQQMVGLERKISEFKNQLAWSFVVESEREAKRKEKQVAEAEERSFDNDIRKVDETIETYNKSIEDIKKDIKEFTDQIKIQEQKKETNNREILTIEREEAKIQTQIEANNKKRQQRKQRRHLQLQSINEIKERNAQLANNQSKLDEIKKKGQQKLQLEARKEELIKEKEDLMRDRENLKRDHQNQRTITQQMNREYEGLRVQLNNLRSTQKGENQAYGKGMTDFLHKIEASRRNFSKLPIGPIGLSLKIKNESWAFAIESAISKATLRNFLVFSIPDGITLQKLGHQFGIKVDYTKIPETTEVYKTVEHDELDPSLATVLRVLDSPSHFIINFLIDTKKVEQIGLGNDRKEIDSVLYTDRCPRGLSQFFDPQGNNYSKTKSGNPFYQAAKNSGEATMLRVNSDAAIQRTQRDMESKLPALNQQKKIEQELSSDVQAIEHKISQNDQDQNQCSRKILQITNEIKSIEDTLVQQTDDYSELEIGLASLDEEIKSMDEEINIQKAQRTEVAAQKGPFAENNRALDDQIDVLSNQLGNIENNLRKFNEGLRKLNNNKQALLQQQGRSAQERDQFKAEYQRILEIVKEKTDKATQICERIEIPTNETNTTLTNKIIQYTKQLEKESRGKRSRTEALKLFQDANNSLKEISEQRDNIEELATILERNLNERYKKWQRFRLSISRRSDQYFNIFLSKKGYTGSLTFDHQNGKLDINVELQKALPSNQNGTAKGDTKGLSGGERSFSTVSLLLAFWENMECPFRAMDEFDVFMDEVNRSISINLLMSKAEENRSKQYIFVTPLALNHIKTSEYVKVFRVRAPVRTGGDVTVETD

smc6

Structural maintenance of chromosomes protein 6

1140 amino acids

Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks. Plays a critical role in meiosis.

Belongs to the SMC family. SMC6 subfamily.

130.929 kDa

MTTELTNVSLEEAITEKTSENRRKRDSDVLQTEEVDLSNVKRIRASRNQDNRPERQSRLQRSSSLIEQVRGNEDGENDVLNQTRETNSNFDNRVGVIECIHLVNFMCHDSLKINFGPRINFVIGHNGSGKSAILTGLTICLGAKASNTNRAPNMKSLVKQGKNYARISVTISNRGFEAYQPEIYGKSITIERTIRREGSSEYRLRSFNGTVISTKRDELDNICDHMGLQIDNPMNILTQDTARQFLGNSSPKEKYQLFMKGIQLKQLEENYSLIEQSLINTKNVLGNKKTGVSYLAKKEEEYKLLWEQSRETENLHNLLEQKKGEMVWAQVVEVEKELLLAEKEFQHAEVKLSEAKENLESIVTNQSDIDGKISSKEEVIGRAKGETDTTKSKFEDIVKTFDGYRSEMNDVDIQKRDIQNSINAAKSCLDVYREQLNTERARENNLGGSQIEKRANESNNLQREIADLSEQIVELESKRNDLHSALLEMGGNLTSLLTKKDSIANKISDQSEHLKVLEDVQRDKVSAFGKNMPQLLKLITRETRFQHPPKGPMGKYMTVKEQKWHLIIERILGNVINGFIVRSHHDQLILKELMRQSNCHATVVVGKYDPFDYSSGEPDSQYPTVLKIIKFDDDEVLHTLINHLGIEKMLLIEDRREAEAYMKRGIANVTQCYALDPRNRGYGFRIVSTQRSSGISKVTPWNRPPRIGFSSSTSIEAEKKILDDLKKQYNFASNQLNEAKIEQAKFKRDEQLLVEKIEGIKKRILLKRREVNSLESQELSVLDTEKIQTLERRISETEKELESYAGQLQDAKNEEHRIRDNQRPVIEEIRIYREKIQTETQRLSSLQTELSRLRDEKRNSEVDIERHRQTVESCTNILREKEAKKVQCAQVVADYTAKANTRCERVPVQLSPAELDNEIERLQMQIAEWRNRTGVSVEQAAEDYLNAKEKHDQAKVLVARLTQLLQALEETLRRRNEMWTKFRKLITLRTKELFELYLSQRNFTGKLVIKHQEEFLEPRVYPANRNLATAHNRHEKSKVSVQGLSGGEKSFATICMLLSIWEAMSCPLRCLDEFDVFMDAVNRLVSIKMMVDSAKDSSDKQFIFITPQDMGQIGLDKDVVVFRLSDPVVSSSALPPSTAP

smc6

Structural maintenance of chromosomes protein 6

1128 amino acids

Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components (By similarity).

Belongs to the SMC family. SMC6 subfamily.

130.513 kDa

MGKRKDGSPIAPSSQRKKQRQEVDDPYDEEDYGQAGPSVSNDYGQRKKQRKEADNSHTDSDYENSVSCASSQRVSASQSGTGDVGIIESIFLRNFMCHSMLGPFRFGPNVNFVIGNNGSGKSAVLTALIVGLGGKAAITNRGSSIKGFVKEGQTFAEISITLRNRGQDAYKPDVFGNSITVQQRLTTDGSRTYKLKSATGAVVSNKKEELTAILDHFNIQVDNPVSVLTQEMSKHFLQSKNESDKYKFFMKATQLEQMKEDYSYIMETKSRTHDQVENGGERLRDLRQECIQKEERFKSIASLGEMKEKLEDLKNKMAWALVTESEKQIKPFIEQISTEEGRTVKYEQKIEECQGKVINAEEKFRAKQEELDKITQEAVALKPQGIGLKEDVQKKRKSYNESEVLYNRHRMELKRLERDAEQLHKRIEELKKSADNDSESEKMARQKEINQIRERMKALHDKDITTNQQIHQFQQAIEKYKEERARIGNEERNIKQRLEQHKRQLKELHESKTDRLKRFGQNMPALLAAIDEADKLGRFRKKPVGPLGACIHLKDQELALAVESCLKGLMFAFCCDNHQDERMLQNIMSREYPRGRRPQIIVNEFIDHVYDVRQRATFHPDHPTVLTALEIDHPVVTNCLIDMRGIETILIIKGKDEAREIMQKRAPPRNCREAFTGEGDQVYTNRYYSSDSRRATLLSRDVEAEISHLEKELRNFGSQMATFQQRAQSVDKDIKENEGILRQYHNSKKQIQIDLRPLLERISELENVEEQPSIDIATLEGEAEENLNKIELVKQEVELAKEKMGNLKSFLTTAEINYEEIKKKISSVAEVAEPVKEDLHRVDQEVENCKRHRKHYEEKLKEHLDRIQKRKEEVAAKEQELEVKISQAKCICPERIEVSRTARSLDTEINRLREKINSEEVLHGNREEIIKQYHEAKERYQDVEGKVKHLKRFIKLLDEIMAQRYKSYQQFRRCLTFRCKIYFDSLLSQRAYSGKINFDHKNETLSITVQPGEGNKAALSDMKCLSGGERSFSTVCFILSLWSIAESPFRCLDEFDVYMDMVNRRISMDMMLSMADSQRFRQFILLTPQNMSSLPSTSLVRILRMKDPERGQTTLPFQPLNQEAEDEE

SMC6

Structural maintenance of chromosomes protein 6

1114 amino acids

Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks. Probably plays a role in structure.

Belongs to the SMC family. SMC6 subfamily.

128.009 kDa

MISTTISGKRPIEQVDDELLSLTAQQENEEQQQQRKRRRHQFAPMTQFNSNTLDEDSGFRSSSDVATADQDNFLEESPSGYIKKVILRNFMCHEHFELELGSRLNFIVGNNGSGKSAILTAITIGLGAKASETNRGSSLKDLIREGCYSAKIILHLDNSKYGAYQQGIFGNEIIVERIIKRDGPASFSLRSENGKEISNKKKDIQTVVDYFSVPVSNPMCFLSQDAARSFLTASTSQDKYSHFMKGTLLQEITENLLYASAIHDSAQENMALHLENLKSLKAEYEDAKKLLRELNQTSDLNERKMLLQAKSLWIDVAHNTDACKNLENEISGIQQKVDEVTEKIRNRQEKIERYTSDGTTIEAQIDAKVIYVNEKDSEHQNARELLRDVKSRFEKEKSNQAEAQSNIDQGRKKVDALNKTIAHLEEELTKEMGGDKDQMRQELEQLEKANEKLREVNNSLVVSLQDVKNEERDIQHERESELRTISRSIQNKKVELQNIAKGNDTFLMNFDRNMDRLLRTIEQRKNEFETPAIGPLGSLVTIRKGFEKWTRSIQRAISSSLNAFVVSNPKDNRLFRDIMRSCGIRSNIPIVTYCLSQFDYSKGRAHGNYPTIVDALEFSKPEIECLFVDLSRIERIVLIEDKNEARNFLQRNPVNVNMALSLRDRRSGFQLSGGYRLDTVTYQDKIRLKVNSSSDNGTQYLKDLIEQETKELQNIRDRYEEKLSEVRSRLKEIDGRLKSTKNEMRKTNFRMTELKMNVGKVVDTGILNSKINERKNQEQAIASYEAAKEELGLKIEQIAQEAQPIKEQYDSTKLALVEAQDELQQLKEDINSRQSKIQKYKDDTIYYEDKKKVYLENIKKIEVNVAALKEGIQRQIQNACAFCSKERIENVDLPDTQEEIKRELDKVSRMIQKAEKSLGLSQEEVIALFEKCRNKYKEGQKKYMEIDEALNRLHNSLKARDQNYKNAEKGTCFDADMDFRASLKVRKFSGNLSFIKDTKSLEIYILTTNDEKARNVDTLSGGEKSFSQMALLLATWKPMRSRIIALDEFDVFMDQVNRKIGTTLIVKKLKDIARTQTIIITPQDIGKIADIDSSGVSIHRMRDPERQNNSNFYN

Smc6

Structural maintenance of chromosomes protein 6

1097 amino acids

Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components (By similarity).

Belongs to the SMC family. SMC6 subfamily.

127.198 kDa

MAKRKEENFCSPENAKRPRQEELEDFDKDGDEDECTISFTNGTSTLTAAEVGIIESIQLRNFMCHSMLGPFKFGSNVNFVVGNNGSGKSAVLTALIVGLGGKAVATNRGSSLKGFVKAGQNSADISITLRNRGDDAFRANVYGDSIVVQQHISVDGSRSYKLKSEKGTVVSTRKEELIAILDHFNIQVDNPVSVLTQEMSKQFLQSKNEGDKYKFFMKATQLEQMKEDYSYIMETKERTKEQINQGEERLTELKRQCLEKEERFQNIAGLSTMKTNLEYLKHEMAWAVVNEIEKQLNAIRDNIKIGEERAAKLDRKMEEQQVRLNDAEKKYKDIQDKLEKISEETNARAPECMALKTDVIARTRAFNDAEVLYNRSLNEYKALKKDGEQLCKRIEELKKSTDQSLEPERLERQKRICWLKEKVKALQDQEHTVNQEAEQFEQAIEKDKQEHGRVRKEDIEVRHALNYNQRQLKELKDSKTDRLKRFGPHVPALLEAIDDAYRRRQFTHKPIGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHADERVLQSLMKKFYPPGTSRPQIIVSEFRDEVYDVRLRAAYHPEFPTVLTALEIDNAVVANSLIDMRSIETVLLIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSESTRPKFLSRDVDSEISDLETEIENKKGHIITLQQRLSALEKDIKRNEELLKRCQLHYKEIKMKIRKNISEIRELENIEEHQSVDIATLEDEAEENKIKMQMVEKNMEQQKENMENLKSLKIEAENKYDTIKLKINQLSELADPLKDELNLADSEVDSQKRGKQHYEDKQKEHLDTLNKKRRELDMKEKELQEKMSQARQICPERIEVKKSASILDKEINRLRQKIQAEHASHGDREEIMKQYQEARETYLDLDNKVRTLRRFIKLLEEIMTHRYKTYQQFRRCLTLRCKLYFDNLLSQRAYCGKMNFDHKNETLSITVQPGEGNKASFNDMRALSGGERSFSTVCFILSLWSIAESPFRCLDEFDVYMDMVNRRIAMDMILKMADSQRFRQFILLTPQSMSSLPSSKLIRILRMSDPERGQTTLPFRPVTQEEDDSAS

SMC6

Structural maintenance of chromosomes protein 6

1091 amino acids

Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541).

Belongs to the SMC family. SMC6 subfamily.

126.326 kDa

MAKRKEENFSSPKNAKRPRQEELEDFDKDGDEDECKGTTLTAAEVGIIESIHLKNFMCHSMLGPFKFGSNVNFVVGNNGSGKSAVLTALIVGLGGRAVATNRGSSLKGFVKDGQNSADISITLRNRGDDAFKASVYGNSILIQQHISIDGSRSYKLKSATGSVVSTRKEELIAILDHFNIQVDNPVSVLTQEMSKQFLQSKNEGDKYKFFMKATQLEQMKEDYSYIMETKERTKEQIHQGEERLTELKRQCVEKEERFQSIAGLSTMKTNLESLKHEMAWAVVNEIEKQLNAIRDNIKIGEDRAARLDRKMEEQQVRLNEAEQKYKDIQDKLEKISEETNARAPECMALKADVVAKKRAYNEAEVLYNRSLNEYKALKKDDEQLCKRIEELKKSTDQSLEPERLERQKKISWLKERVKAFQNQENSVNQEIEQFQQAIEKDKEEHGKIKREELDVKHALSYNQRQLKELKDSKTDRLKRFGPNVPALLEAIDDAYRQGHFTYKPVGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHADERVLQALMKRFYLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDFPTVLTALEIDNAVVANSLIDMRGIETVLLIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSENTRPKFLSRDVDSEISDLENEVENKTAQILNLQQHLSALEKDIKHNEELLKRCQLHYKELKMKIRKNISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEAENKYDAIKFKINQLSELADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKRELDMKEKELEEKMSQARQICPERIEVEKSASILDKEINRLRQKIQAEHASHGDREEIMRQYQEARETYLDLDSKVRTLKKFIKLLGEIMEHRFKTYQQFRRCLTLRCKLYFDNLLSQRAYCGKMNFDHKNETLSISVQPGEGNKAAFNDMRALSGGERSFSTVCFILSLWSIAESPFRCLDEFDVYMDMVNRRIAMDLILKMADSQRFRQFILLTPQSMSSLPSSKLIRILRMSDPERGQTTLPFRPVTQEEDDDQR

smc6

Structural maintenance of chromosomes protein 6

1090 amino acids

Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components (By similarity).

Belongs to the SMC family. SMC6 subfamily.

124.809 kDa

MSKRKSISTHDKSTKRARPVEEEEDSEDADDRDQDVERLSPQVLPSGDVSDVGIVKSITLNNFMCHANLGPFAFGSNVNFIVGKNGSGKSAILTGLIVALGGNAQATNRGSSLKGFVKEGESFAVVSITLNNIGKDAYKPEVYGQAIVIDQKITREGIRTYKLKSQSGHIISTKKEDLVTILDYYNIQVNNPVTILTQEMSKYFLHSKGGAEKYKFFMKATQLEQMKDDFVHIKSTKSVTVDKVEQHSECLKDLKRDYLEKEDRYKSLASVNEMYTKLEELKKQMAWALVGEVEKEFEPMKEKLESDRCATNKFNEKVDEWKKKVEVAEGKQKQSHEQLEEITQQVSELQSKCTEFKTEVQRRNADLKSCEVTVHRHKAILRDLEKDKAQLSSKINDLSLSISQATGAESQARMERIAQIEAALEDLTHHTSTLGQQIEQYQHSYRHAIEGQGKMKRELEGLQKSIDANRRQLQSMESSRSNRLQRFGDQMPALLAAIDEAHKKGQFKHRPRGPLGYLISLKDPELALSIEICLKNLVQAFTCDNYDDERVLKSLMTKVLQHGRRPAIITSRFFPKVHDVSVRAVNHPDYPSVLQALEIEDPVVANCLIDQRAIECILLIKNRTEARRVMQGRNPPQNCTSAFSVEGDQIFTNRSYTADQTRANFLSKDVEEGIRHLKREMETQKVQAAHIQQQIRSTDKNISENQDLLRRTQTEQKTTEVKTMKLQLELTDLKNVEEPQSEDLAELKSAFENAEQEYKQHKQLIDTAAEEADVKKVETKLTPLFTSLSCNILWVHCLFVLLQEELSKTDQEVMKCKHHEKHYEERRNAHLCSIKTLENNVASKEKELQESIAKAKEICPEQLVVRRTARSLDVEITRLKVKIATQREHQGDREEIVREYHEALESYANKAQQIKNLNNFIKCLDRVMDQRLYAYTVLRRFLSARCKYYFDSMLAQRGFTGNMTFDHKNETLSISVQPGQGNKADLNDMRCLSGGERSFSTVCFVLSLWPITEAPFRCLDEFDVYMDMANRRNTQRQSGLKMATSQKIRQLIFLTPQSMSSLPECRRIHIVQLNDPVHGQTQMEQEEEGP