About Products Protein Database Contact

sls

Gene
sls
Protein
Titin
Organism
Drosophila melanogaster
Length
18141 amino acids
Function
Key component in the assembly and functioning of adult and embryonic striated muscles and muscle tendons. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase.
Similarity
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Mass
2065.766 kDa
Sequence
MQRQNPNPYQQQNQQHQQVQQFSSQEYSHSSQEQHQEQRISRTEQHVQRSQVTTQRQVQQHHGGSIGGAYVPPSLTHVYAQGDISPPVFEQIFKNARFAQGGNALFEGRLRGNPKPFVTWTRKGAPLLESQKFRMSYNEATGDVSLLINQIGPGDEGEYTCTARNQYGEAICSVYIQPEGAPMPALQPIQNLEKNIYSNGYSYTSIEEEFRVDTFEYRLLREVSFREAITRRSGYEQDSQLSQELDRNQGPAQAPQISQKPRSSKLIEGSDAVFTARVGSNPKPRLTWFHNGQRLVASQKYEISYSSGVATLRVKNATARDGGHYTLLAENLQGCVVSSAVLAVEPAAETAYEPKPVDVMAEQLEAGKALPPAFVKAFGDREITEGRMTRFDCRVTGNPYPEVFWLINGRQVRDDASHKILVNESGSHSLMITNVTRLDAGAVQCLARNKAGEVAIEAQLNVLEKEQVVAPQFVQRFSTMTVREGEPITMSANAIGTPQPRITWQKDGVQISSTAERFVGIDGGATCLEIPRVTANDAGWYQCTAQNIAGSTANRARLYVEVPREQPNYEQRRLNLPRPTKVIEPEPIPGPEIIYLRHVERAKPHLRPGEEDRVYPPPQFIIPLQNVQQTEGGRVHMEARIEPVGDPTMVVEWYLNGRPLAASARATSVFKFGFIALDLLSIMGHDSGEYMCRVTNASGVAESRAILSVVQRPSIEQSSQNPNSLQYINQLEDYSRYQRTESIDEQLNQAPQFIRPLRDLGEFEEGKNVHFEAQVTPVNDPSMRVEWYKDGLPITASSRITAIFNFGYVSLNILHLRAEDAGTYTVRAVNRIGEAISQSSIRVHSRSQVTADLGIPEQQRYIEKVEELEDYRKSQQRRHVQEAAEAIAPPQFKTPIQNQLDLREHAHAHFEARLEPVGDSTMRVEWLKDGQPLEASSRITTYHNFGYVALTIKQLTIYDAGTYTCRAYNAMGQDTTVAQLTVISKNEIVSESQHPGGLQKIQHLEDSSRYGRREEEETYITQAPRFLGPLKGTTKILEGQRAHFEARVEPQSDLGLVIEWYHNGRSITAANRIQTYYDFGYVALDISQVRAEDAGVYLVVARNKLGEAQQQATMIVETRSSIDTSSMHRGLYEKTQNLENKPFVEPQYDIEEISKSKPVFVTPLSDPKPIHDGKNIHLECRLEPMGDPTMRVEWFHNGRPVTVGSRFRTYYDFGFVALDIIKATAADSGEYTVRATNHLGTAHTSACVRVIDHTDVVTETQNEQSLEQIQLLEDSRRRHHQEEDITIMQAPQFTRGLHNIETIEGTNVHLECRLQPVGDPSMRIEWFVNGKPVKTGHRFRPAYEFDYVALDLLGCYAIDSGVYTCQARNQLGEAVTSCSVRIIAKNDLILETQNESGLQKIQYLEDSTRHRRSEFVDEVVNIRPRFLTHPKSLTNTREGGHAHFECKIEPVTDPNLKVEWFKNGRPITVGHRFRPIHDFGYVALDIVHLIAEDSGVYTCRAVNLIGSDETQVELQCRSGEQIVTVTQNEAGLEQIHYLEDRSRYTRREEIDESTKQAPVFTTSLKNVEIKENQRAHFECRLIPVSDPSMRVEWYHNNLPLKSGSRFTETNNFGFVALDIMSTLPEDAGTYTCRAYNAVGEAITSAVAVVHTKKSIYLESQHETALPRLQHLEDGSKRQRISVQDEFVSQAPVFTMPVRDVRVAENQAVHFEARLIPVGDPKLTVEWLRNGQPIEASNRTTTMHDFGYVALNMKYVNPEDSGTYTCRAVNELGQAVTSASLIVQSKTSIQLETQHEAAMHKIHQLEDHSRYQRREEEEYTVTTAPVFVTKLIGPSNLVEGQSAHYECRIEPYPDPNLKVEWFHNGKPLSTGHRFRTTYDFGFAALDILTVYAEDSGEYTCRVTNNLGEAINSIVLNVTSRSSIIHETQHEEALTKIQHLEDTSRFQRKTDEEQFHAERPQFGRPLRNAKVNEGAPVHLEATLIPVNDPTMKVEWYCNGRPIQTGHRFKTTYDFGFVALDILYAHAEDTGTYMCKAKNAIGEAVTTCAVNVTANKTLDLDTLDAQRLEKIRQLETYAPPPKPVVEEKGQKPIFLTPLSNLEHLKEGEHAHLECRVEPINDPNLKIEWFCNGKQLPTGHRYRTTHDFGYVALDILYVYGEDTGTYICKATNQLGEAVNTCNVRVLNRRSMILDTQHPDALEKIQKLESKVPNARTEVGDAPISPPHFTAELRGSTEIYEGQTAHFEAQVAPVHDPNLRIEFYHNGKPLPSASRFHITFDFGYVSLDITHAVAEDAGEYSVRAVNALGQAVSSTNLRVIPRGTIISDTQHPEGLEKIRKLESTAPHQRQEPETPGTRQRPVFTQPLQNIDRINEHQTAHFEARLIPVGDPNLKVEWYRNEKIIEDSSRITKQHDFGFVSLDISHIRKEDEGVYMCRAVNPLGEAVTTASMRVVSEASIQMDTQHPDSISRIHQLEKPLAPRPTEPERLFEKPIFTQLLTGPSELWEGTHAHFEARVVPVGDPSLKFEWFINGVELQMGSRLRTTHDFGFVTLDITAVVPEDAGVYMCRAYNAAGEAVSSTAMKVKTKSNIDGQPLIPESWEAIRLKEAAMNRVPEMFVDSTPQQAPVFTTHLQSYDKLHEGQHVLLEAQVEPRADPNLRIEWFKNGISLTTGSRIRSTFDFGLVTLSINGLRADDSAIYTCKATNQVGEAVSTSSLKIEDRHWLQAESLHPDSLPRIGELEAPKEGRPEAPEPTYETPVFITHLNNIECKESDNVRFECNVEPARDPTMSIEWFYNGQPLQAAAKFKSIYDFGYCALDLTNSYAENSGVYTCKATNSKGSATTSGTLKCTGGKTMFLDTQHPQGEAGLEAVQETEEELANRYTSKTTKPETQYPPPVWTKPLQAEFHLSEAQPIHLEANVEPKEDPNLFIEWYFNGKMLNHGSRFKMTSEFGFVTMDMIEVYARDQGIYTCKAYNKAGEAFTSTTIFCSSKENIIESTQHPKGAEGLEQIQDLEDSLRKDGSKPEQPDLGIPPRFTTEFVNIADIGEGELAHFEANLIPVGDQSMVIEWFYNGKVLEASHRVRTIYAFGTVALEVLGTKIEDTGTYTCRATNKHGTAEISCNLECVDKPRGQKPRFTSHIQPLEGLKDGQSAHFECTLIPVNDPDLKVEWYHNGKLMRHSNRIKTVSDFGYVVLDISYLQDHDSGEYVCRAWNKYGEDFTRTTLNCGGRGGVFYDSLQPDSLQRIRELECPQGQQADTSAPLVAEPPKFITQIVDVTKLVEGQSAHFEARLTPITDPDLVVEWYFNGKKLPHGHRFRTFHDFGIVILDILYCYEENSGVYEARARNKYGEDVTRASLKCASKSSLILDSQLPRGMEGGLEKIANLEYSMVRTREETTEETKGKAPVFTVPLENIENLREGENAHFEARITPADDPKLKVEWYWNGRPLKAGSRFRTFCDFGFVILEISPVYPEDSGEYSCRAINEYGEAVTTATMKIQGKRSIIMESQLPKGMEGTIDRIAELEGLGSRSTEFVPDDDTGKPPEFITSPFDMVIGENALAHFECRLQPINDPSMRVDWFHNGKALWAGSRIKTINDFGFVILEIAGCYQRDSGLYTCKATNKHGEATVSCKLQVKGRQGIVMEPQLPSNFRTGTESLQKLEETMHKREELVTEDEQPNPPKFTEEIKDNLDVPEGGPIHFDCRVEPVGDPTMRIEWFYNGHVMATGSRVHQLNDFGFIALDVDYIYARDSGEYTCRATNKWGTATTSAKVTCKGKHNIVYESQLPEGMTSEKLKELERGRIPEAPKVVEEVFGPPKFTTQITSVTVDEAEAVRFECQVEPKTDPSLRVEWYRNGKPLPSGHRYRNIFDMGFVSLDILYVYGEDSGEYVCRAINNYGEDRTRATVSCKKLPTILLQNQVPRGMKRSDALTQMEATIKKYTSEVHLTEDDLFDPDRKQPPRFVTQIKEQLTLTEMAVTKFECQLAPVGDPNMKVEWFFNGKPLLHKNRFQPIYDFGYVAMNFGWVYPEDSGEYVCRATNLYGKDETRAIIKVSGKPGIVYDSQLPAHMQSIDRIREMEASWQVVPDEVDPDAKPRTKPVFVSKLEPQTVEEGDPARFCVRVTGHPRPRVMWLINGHTVVHGSRYKLTNDGMFHLDVPKTRQYDTGKVEVIARNSVGESIATTELKVVARSDDYRNVLKNSPRPWYDYELAAYQKERQENELEKVFDERKQVLSEQSSHTLKGVEHLKPKQYKPPTPDWQQNVKAKKSEDYYNKLQTLETEQLLKETNLRRDTHQYAIPGEKVVSSSQAKGMAQSYEENLQEKTSTTEVQAAPPKGIAQPSESSVHGREVHMNKQQQVQKEIQGDLEITRKITATETTEVEHKGTIQERVVQGPVKPAKAPVFTKKIQPCRVFENEQAKFEVEFEGEPNPTVKWYRESFPIQNSPDLQIHTFSGKSILIIRQVFVEDSAVFSCVAENRGGTAKCSANLVVEERRRAGKGGIQPPSFVTTIQSTTVATGQLARFDAKVTGTRPLDVYWLKNGMKIQPSIKFKMLEEDSVHTLLIIEPFAEDSGRYECVAVNAAGEARCDGDCIVQSPSKPEKPTTPGSEKAPHIVEQLKSQTVEEGSKVIFRCRVDGKPTPTARWMRGENFVKPSRYFQMSRQGEYYQLVISEAFPEDEGTYKCVAENKLGSIQTSAQLKVRPIENLDAPPTITALKDVSVTEGMPAQFKTTVTGKVKATSVQWFREGQLIPETPDFQMIFDGNSAVLLIGTTYEEDSGIFTVRVTSSTGQVESSAKLTVKKRRISAFQLRTIDSAEDESSSSGREDSAPESPHAFQPGQQPGQQFGQFLGVNGQGQHQGRSRQKKPKVRSKSLQPATKVIPWRKSSRPTRGRSLDKGVFLPGFKPEPVKSWTEETINLKATPIEKKKPAPKLEAAKVVLKSIKTERDQGIMSLGATLEQIIAGKTEKEAIPWITMREKLKAVESVQQQLNKFDLDEVYLQPLEGQIETEGQLPQQAQVEQVQRTKEIQRLKSMESVEIMEMTDQIDKLITQQQNAKDLIPWKEMRQQLKSVQRVTKQIDKFKIEEVELRHLQAQQAITEEYQTGTAEETVVMIDESSKGSISKVLRRDEQLQYEDQSNIYKQKFITTEDVNIMHVSEREKLEAQRLIREQQAVNWRQQQQRPQLQPLTSVEDTVISQTSERQKLVQQQSFIEEAQRQQFVQVEDSQMMSLEEYEHQKIINQRTQQEAFSWRQPREPQKFIQVEDSTLLHLQERHDTQEQQLLQQQPVMWDRGRKKPDQPQYVQPQEQRVKEEFVEKPKTYEEMHDELVEPTPIEQPQPVPVMWERGKKKPQPQEKTFEEAHDELVEPTPVQQPEPVPVMWERGKKKVAQQETVLSQEVVQTSQVVEQQIVEETKKTAVRRVIPPREPEQKVEQVTLKPTPRPRPKEAVKAEEIQLKPLRSTRPVPQPVEAEQKAYEEATDELTEEPIPQPQPVMWERGKKKPQKPQEEVTEIPKTLEIAVDTLEEEVPKPTEPQPQPVLWARGQKKPQKPDEQKQELPKSLEIAVDTIEEDLIKPVQPEPQPVLWERKKKKPQPQDVIEEKLDVAPTKTYEKAVDVLPDEPKVEEKPEPVLWQRGKKKIPKSEPTEEVHPDEVDAQIETVVKEDEMIVEEKRRIKKTKRPKSTKEVTEELFEEQPEEEISPEEEVPQKEVIEEIEEIVEEKRRLKKTKKPKLTQQVTEEETPHEEIIKESEEVVQEQEEIVEEKKKVKKVKKPKTVAEKQLKEEEIPTEETVEEEETAEDQQLVVEESKKVKKVKKPTGTVEKTDVEELPGEEVPVEEVPVEEVPEDVAPEEELIEEQEEIVDQDEIQEQKRKVKKAKKPKKTIEKTEIEIEEDQPEEEVLQEEIIGEQEEITERQRKVKSIKKPKKVVTEKTVDQTEQPEKPEESQAEEVKETVTEEPKKPKPAPEEAKVEQVEKISLKPAPRKQRLLPEKEQVEEVLLKPVKKIVAVSEAEQPETPETEFEVKEFAITTTEDILDVTKKRVKKKKPKTKVAAEESTEEPAEETEEFEEEATQPEEVQPVEEIPEEPQVKEVADERKTAPKPKPRKEEIIEKVEEVALKRVTRPKKELPQEATIEEVRLKPTQRTSIKPEEVKLEEVDLQHVEKKEDEIVQEEKRKTRKVKKPKHEDLPEIPDAEPTQLEEAEHIELEKQPKPEEDQPQVPWKRGEKKQPVEEVLEEKKWPSGKRRPLPEQQPEEVQLKPIPSKPIEEQQKPEKAIPGPQLVPEEKPESEEEELELEPLKLPEDKKPKEPKAKKEKKKKPKLKKATPSVDEVSEEVAEPFDEPIAEEDEVEEMPVDDVKVVAVSEDVLPEEEVVPTEETPEAKQKAHKKRTKRLKEASVEGQPQLLEAAIAEIEKVDEISQEISQKTITLLKKTEDTRPQFITTEQLIELDVEDVRRDLEMKVTSNIIKKEKRRVVLDDSQPLPELELITQKRIQEGIDKVADEELIEDQQLIQNQQETTTSEVIGQERKLVKKKKKEIKPPRITEKLRPRQCVPEEPTVLECKVEGVPFPEIKWYFNDILLFASEKYEITVMEQVAKLKIAKVTPSDVGVYTCEAKNEAGVATSRTNIILEKEQGVPPQFTKPLKIEFIEEKQPERLKVTVTCQVTGKPNPEVKWYRGIEEVIPSETVQMFYDEKTGDVALEVINPTPNEAVVYSVQAQNQFGRAIGNANILSRVDEVPREILKAPTVTPLSAVVVPTGGTLFFEAKYDGLPRPEVKWMRNGREIIENEETIIETTETTTTIKVVNMTRKRTGKYEVWAKNKVGEAKSSGSVVVSDQKPDEQIKPPRFIQPLEPKYFGEHEVAIIEAIVESEPLSSFQWFVHNEPIKSSNEVRIVSQANKSTLLIENFQSKFVGPFTCRAENVGGSVTSTATVNLIPQEEAEEFESPRFVEELVQPVEVMDGEALLLTCQVTGKPTPKVEWYHNAEKITENKETTISQDLQGVCQLQITEVFPENEGQYECVATNKIGKSVSKTNVKIQAFEYIPDSEITGLTGSEEDLLDRTLSIDEQAPKIIKKLPEKIEPKEGEQAKLEVKVVGKPKPKVKWLRDDEQIFASEEYQIENFEDGTSVLVINHVYPDDLGTISFEAYNPLGVAVTTALFAVEGIVGSKDYRKPEWVSQMEEMQVALKAAKCSPSLLNEMRDCRAALGETAKFSIQFAGNPIPDIQWYFNNVQLRASEKYRMVVQEQEATLEIMKITSEDCGYYNCKLINEIGMTMTRAKFDISSTSTIVEETKAKTTVKKKSGKKTMVKRSGASESQNVQKTEIRIIPTSAVETSMNVIKVKQPVSVLVEKSEISEVLVVKDREVADAEERSSQLIEEIEEEEEIEEKVQHDEEDEVEVQVEQKETYTSSKKIEITKTVELIRTKISEKIITIEDVQVLSHHEEVQWLLESIEAESFGQIGESALRDLATIGLLLRYGCEHYEITYMYEQNIFISLKKPESQSALVQLVEREGHEELISQILSESSNEDETILAATVGFKAFIRMIQTYEITIEIVIRKFVREDFISQDWKICGKERIVETSQIIESHEAITHVKIETATTKVEKLFKKQEQEHVQNLEQQEQVKIQVQTKQIAQMNTKIKKHKKHKQQEQEVSETTIQCEQKETLAHETSAELPQSETLEQIEESLSTYETLPIQNLSKDTLQTVAVSVTTELSTPSPTASRVQEEILPQKVLAINEEVLPLDEFGLRKESPRPKENKLTENIEVRLKHALNVSHAKTAESSKELPSKIPKSVKAQRKMKESRSLVVEAPNAEEAIEDLKPLKAVSQEVQSDILFSHEITEEQHQALETIEKLKPTSAIEDTVQQKLLSQEELIIAEVLPSETVGRDVTDVRPPGETISPRLTPNMSLCITECQPEDSIGEMQQAAKERMETPSMSVTESKAVGGQELEVLENVDHMPLITQPTKGLADYTIKAEEVPVQVQEIITFDSLERETVAKTQTAKSNALELFELSEGLVSSTADSHSPIAEDLPIFEKDVKEATIDMQMQHHVTTSETVSNENAVKDLKAVDTPKMAEGTLGQSSALTIGETQQMNLVETTVELIEPNVESTKPAKGALTEAYGTAESNEETLLESLGLVPDDNRKIEQGKVNISEGEYVAKVQTTTVTDTEGEFVSVAPKLVNPKFDFVEQSALQIKQDTTVEKEEILSSNIELAPQLATSNMFPAELKVTSIYEVQPGLTSSDIITEQTKSVSANQVFETMSIGVTSKPDMLESTSHIDAFQHPEFKTGDTILDENQQPLEVTNVQITESSTDIIDVLPNQKLTKAETVTDGFKYAEGLVVLPMESTIDKTEDTKPTAVNADISMHQQFGTDVREQEPLESTLTRTEDLKPQTQTTESQFGLLQSLETSSCVTLEGESVLSVKERHPEQSAAIGTSSALQVANITRPQHMESLDRLDEQKVPYYQANVNIGEITLPNVEKIDSFDVLSDLNTPDYNKSSKGRVQLIESTTSLKTTTAVVSESTEELKDLNITQPVHIKPKPYESDQKISISEQTNVLEHVSSLNPVLPALETIQSSIKSLHEINVRETDILEKEESLKDVDHISGRLAKIILDCTTGIAQVRQEETLEHEEDLKAPLIPLEKAIPASSELHRLPLTEYVQEQQGTSDMTDFKVSNKCASPNIDHLYETKSSEMIVYDSSINSVDSEFPAGIVPQKSLVPFRHTMVTENVAFNASENFEILSADQQIATNVQDSLSQSIIAEDQIAFETEQNLGLETTPTHKPKLLKDDQNLHAKLVDEATVYEAMGQEQKVDKYNIQQAEITHDLPQVYATDLQQTFEAEKEITTREQSYVAATTDIIPSRLGLAMTTKTHPVEGIDVLLSSPPKPSLAQTNYEETQHEVRVRETQAIEESEELTDGRLLPVSAVESIDSTFKVTSDSQQPPVFDKELSIPTVSPLEARAKPSLNLLQGTTTFDVIPLESSVLLKDTHVAVQKAQQEYVAQVESNKVHVQMDNLVMHKEDIFENAEIENFCKPITEGTQLETVVIEVVPIDNVGGIHLAPQPSTLLATLTSTDIVNQSHVIDTQVPLEMESEAQAPLDNIAQARIKSAEDHVHTNVSEVNVYEQTKAIQDQNKHGLFVKVSKNSDTSKAYLTTIQSTFLKEDILPKPNILQDTAQAAADELQSLVTEEVVSVSSIQETYELKIPLQKTANLTQQTPQNSVNVCQQLAYEETPDIAFEPHALTRATTSSVPTFLKPAENATVNIYENIEGHGDFKPGTVNLTSNSNLNSELVVSVVQEVTSVPSLGSLATVEPQELKAMPVTKSSTNLAYSEEVKGNKQEFTKIETVEEDDKQPETTVTVEELPYEEEKPEEIQELPEEVCVVETVTEDGKPKKKKIRTRVIKKVKGDKQEVTKIETVEEDDKQPETTVTVEEVPYEEEKPEEIQELPEEVRVVETVTEDGKPKKKKIRTRVIKKVKGDKQEVTKIETVEEDDKQPETTVTVEEVPYEEEKPEEIQELPEEVRVVETVTEDGKPKKKKIRTRFIKKVKGDKQEVTKIETVEEDDKQPETTVTVEEVPYEEEKPEEIQELPEEVRVVETVTEDGKPKKKKIRTRVIKKVKGDKQEVTKIETVEEDDKQPETTVTVEEVPYEEEKPEEIQELPEEVRVVETVTEDGKPKKKKIRTRVIKKVKGDKQEVTKIETVEEDDKQPETTVTVEEVPYEEEKPEEIQELPEEVRVVETVTEDGKPKKKKIRTRVIKKVKGDKQEVTKIETVEEDDKQPETTVTVEEVPYEEEKPEEIQELPEEVRVVETVTEDGKPKKKKIRTRVIKKVKGDKQEVTKIETAEEDDKQPETTVTVEEVPYEEEKPEEIQELPEEVRVVETVTEDGKPKKKKIRTRVIKKVKGDKQEVTKIETVEEDDKQPETTVTVEEVPYEEEKPEEIQELPEEVRVVETVTEDGKPKKKKIRTRVIKKVKGDKQEVTKIETVEEDDKQPETTVTVEEVPYEEEKPEEIQELPEEVRVVETVTEDGKPKKKKIRTRVIKKVKGDKQEVTKIETVEEDDKQPETTVTVEEVPYEEEKPEEIQELPEEVRVVETVTEDGKPKKKKIRTRVIKKVKGDKQEVTKIETVEENDKQPETTVTVEEVPYEEEKPEEIQELPEEVRVVETVTEDGKPKKKKIRTRVIKKVKGDKQEVTKIETVEEDDKQPKTTVTVEEVPYEEEKPEEIQELPEEVRVVETVTEDGKPKKKKIRTRVIKKVKGDNQEVTKIETVEEDDKQPETTVTVEEVPYEEEKPEEIQELPEEVRVVETVTEDGKPKKKKIRTRVIKKVKGDKQEVTKIETVEEDDKQPETTVTVEEVPYEEEKPEEIQELPEEVRVVETVTEDGKPKKKKIRTRVIKKVKGDMQEVTKIETVEEDDKQPETTVTVEEVPYEEEKPEEIQELPEEVRVVETVTEDGKPKKKKIRTRVIKKVKGDKQEVTKIETVEEDDKQPETTVTVEEVPYEEEKPEEIQELPEEVRVVETVTEDGKPKKKKIRTRVIKKVKGDKQEVTKIETVEEDDKQPETTVTVEEVPYEEEKPEEIQELPEEVRVVETVTEDGKPKKKKIRTRVIKKVKGDKQEVTKIETVEEDDKQPETTVTVEEVPYEEEKPEEIQELPEEVRVVETVTEDGKPKKKKIRTRVIKKVKGDKQEVTKIETVEEDDKQPETTVTVEEVPYEEEKPEEIQELPEEVRVVETVTEDGKPKKKKIRTRVIKKVKGDKQEVTKIETVEEDDKQPETTVTVEEVPYEEEKPEEIQELPEEVRVVETVTEDGKPKKKKIRTRVIKKVKGDKQEVTKIETVEEDDKQPETTVTVEEVPYEEEKPEEIQELPEEVRVVETVTEDGKPKKKKIRTRVIKKVKGDKQEVTKIETVEEDDKQPETTVTVEEVPYEEEKPEEIQELPEEVRVVETVTEDGKPKKKKIRTRVIKKVKGDKQEVTKIETVEEDDKQPETTVTVEEVPYEVEKPDEIQELPEEVRVVETVTEDGKPKKKKIRTRVIKKVKGDKQEVTKIETVEEDDKQPETTVTVEEVPYEEEKPEEIQELPEEVRVVETVTEDGKPKKKKIRTRVIKKVKGDKQEVTKIETVEEDDKQPETTVTVEEVPYEEEKPEEIQELPEEVRVVETVTEDGKPKKKKIRTRVIKKVKGDKQEVTKIETVEEDDKQPETTVTVEEVPYEEEKPEEIQELPEEVRVVETVTEDGKPKKKKIRTRVIKKVKGDKQEVTKIETVEEDDKQPETTVTVEEVPYEEEKPEEIQELPEEVRVVETVTEDGKPKKKKIRTRVIKKVKGDKQEVTKIETVEEDDKQPETTVTVEEVPYEEEKLEEIQELPEEVRVVETVTEDGKPKKKKIRTRVIKKVKGDKQEVTTIETVEEDDKKAETTVTVEETELSAPSVGKVQLKKRVIVQKPEDAVTVFELPERKSVILSEKEDGTPTKTVIKTRIIKKIQGPNMEVTKVQTVEEYEKAPQTIVSVEKFNTPFPELPEERLSEVVMLPDEVFESEAVDEEGRLKMIKTKKRIIRKPALDNTEEVTEIGIIEQDNVEPIYSVKIQERPLTESKPEDSKLIELPEHVTELNVILPDGKKKRRTVKSRAFKKSLDDDLDEVTTIHIIEEEDKEPLTKVNIEVVPSDEISITPIPIEELPEETVFTEELDENKKPKKKTTKTRTFKKRGPDDDEYFQIQTIDEEGKEPISLIRVVSDENIADIIDISKLDDEKVLKHKQKPHKHKDQYYKEYTITEPEEASADALQKPTKDKTPKQKKTLETPIEEVDETVIIDEGTGEQTDQIAIKRKPRKVQGNVQVEAVDEKPIEKKEKAKKKKVVKTKRDEMDDYIQFLIHQEIPKTVLQPYQRTEMELPQRARRDSSFKQPVKLTPMKIEKVEFKKPKMVEISSVVEFPQMLKLKAPKQRPQEEKKKKNEASFKNKKLKSWIRFVPYAPYCFPYVVTELETNREVGELSRNVDEAEEVLKLRPKKFKHSKPEKAELEEADLGAYESDHSDKSNKELLHPKYKRGKKEKIETPDESRKLKFGKGKVPQNEEASEEVNLKPVKLDIAEIEDAEMPVRTQEEEVVKKKKPKKSSKPEEGLQFEPIEFEEMERTSDIREESDTSVSVDTSTQEKPIYKKKKKVTPSPQKNQYKILPGQPREFEETPEDDLNLRKRQGERPDDDKADTKLKPFYKFEVLDLEPEGVQAETVPLSETIAKEPKKKRKIKVKTEQEDNTIEIVPLSPEDNDEQIFEITVTSSEIPQGDAKAKTIGKKKVKRMNKQELDDFVTELQEEPNQEVYETRMSDFYEVKLTELPSEMDSDKPTKRILRHEKGDEVQVLEIVESVVAPGEEPFYEINVISSANTEGDSEEITTDKIKKKSRKIKKDDLDAYIQQLINAEIPVTELEKYEKIDVDGKAKKPKKLKAKTKKPIIDEGETLQVGVTEHEPTKKLKTKKPEEKKNVIEKELAEHEAVPEYDEFLINKTESERPQEKRVEETEKDIVPIVDKVLADLNDCLPFVVVEEDLKDMPLATDVIALEDEKIIRKRKVRAKKDSKQYEIEIIETEKPGDIPDEARVIVITTEVSGDTIDGPAPSTTEAPKKSVRKVKKEKLKEFIVNIVEEAPLDHVSEIYEDVLRTPFRESSEKEDIPSFTTTVVEDEIVNPVLPEKIKTVDDVRVPKDKKKKIDNQKKIKISEFEPTPTSEDSTIEEYTPKLSEHDEDLQTDEYSVDVKDSLPKSKKKSTKKQKKESLPGPISLYTIRIEETTPEPITEKIYEDGKEVVRVINKRRIKKKAGPKEYLIEVIETYEDNNPEADVVIRTIETTPSIDSKPQEDHKIQVVQEKKPKTESLDNYIQKLIDQEIPQVDHKEFKATVLETSPESKKAKKIKKHHKKTTEVIDGIPITVIEVTIQETETDDEDFKPDEVTLKEIDHENAEEAPKVLKSKVSEEKPKSKKEKSLEFKIAEEDKPKPVLEDISEDVQVVQIIEEDGTPKQVEIKKKKVSRKHGPKEQVFEITETKAIDEPLSEVTVVEITDEQPQEEVLPAQEKKPIKKQKKLKPEDVNTYVVKVLEELTEPTQFETIPEDADDKPQPVIEDISENVQVVQIIEEDGTPKQVEIKKKKVSPKHGPKEQVFEITETRPSDEPLAEVTIVELTEEGLNKDIVIPQEKKTVKKPKKLKPEDIQSYVIRVLEEFNEPQWPASTEKPIIEDIAESIEIVPVTEEDGITKEVEVKKKKVSRKQGTKNQVFEIIETKTSDEPLAEVTILELSGDKSQEVTILPKEKKPIKKTIKLKPEDVESYVVNVLEEFCEPQSFESPEPTEGEAHETKTKTKKPKKPIVKAPENVILIEEMAPETVIENIVNEIGEEVKQVKTTKKLKKKEGPKEYLIEIKETYEENKPEGDIEITTTELVPEGSPDASDDQPVIVVQKIKKKKPVKDDLDKYIQQLIEQEITKTPLEEYEPTEMDSKKKPKKKVKSHNKKTIEVIDGLPVTIHEFNVEDIVSEPEDMETPKTLLDEIKEIPQLPDDSSKYLVNISDEFGEADKPIKQPTQDQPIKKEKPLKKKKDVEYPVSLEAFDHTVKVVSEPTLEGTVKEVTVKKRKVSRRKGSKDHIFEITETTSEDRPTAEVTVVELSSDEVLDSEEKPKHERKIVKKPKQLKKDDVEEYIINIIEEFIQPIPVGLVEDEVEKVQKEETKKPKKSPITYIATEQEDNDNNYDALVKEDLDQPIERALEKPSSPLEYTISVEEDSVGEEQKQPKPKKISKPKSIKQPSVDKSPDYLVNVISEESIIDEPIPEDYVVTEAAEEKPSEEPTFKVEELETEAVEKEVTDDDKGETTKQSVTKRKIKKLVGPKEEIIEIVETKTGDTPEYEVIVTTEEVQEKSKEAPEEKKAKTVRKAKKIPKDDLQDYIQKLIEQDIPKTELEKYEKIDLDEPVKMKRKPIKKVKQSEEQPKEETEEPIEDKPVEKISEYSEVDSDEPKLTVAVKEFIPEKPEEKPFEIVVLEETVESKREPDEEGKVREKVVKTKKIKQNRGSVEVVHDIVEEIDTDTNESVITVTTTVPTETPDQDQPSVKQKRTKKIKKDEVEDFVKRVIEEEAPQPEGSVDLVVIEDFVPKPSSEKRKKKPIKDKHTSVEEETPHEDEVLLIESVPEDSPLSDDLITVVDSVPIEEEPENKVNQIEDTKKPEKKKKPKPSAKILEENVPEDTVEKPLEALHTDSDLEKPDVQEFSISIKEEEQKHTHPEKKKSSKISSEQPKQPSTEQYEISVTEHDLKPEEEKPFTVQVIQSETNVEETKDDTGKVHKQVTTKRMLRRPAGEGEIEIIEVVRDDQPEAEITIVEYEPEPVNQDEKPKEPKKKTRKVKKDDIHDYIQKLIELETPKTELEKYEKIEFEPIVKDKPLDSPIDVLDESPKEVQKKDKKSRSTKVPNEETPVQEQYAKVNVVEEEAPEQPEIPVQILEVKPVEVDVKEVITEDGKPVQEKTTKRVLKKIGPEEQTTFKITMIESEDNDSVTVIVDEEPEIASPQSIEEHPEQSKEKLAPKPKKTVRKVKKDDLSDYVKKLIEEEIPKVDLEKYEKVEMPEKPVKLTVSDSIPEEPKPDKSQPISVLPDTTKPKKTKTPKTPKTEDTDQQVPDEPTETTVDTTDIPELTPTQTAQPEDTATAQITPSAQEEKSTQDDTKDTIQKTVKHKKTKPDTQKSVETSELPEVHKDYQISIIHEELVEEEQPEKILEVRVIDEVAEVEESQPIVEEVEDEEPQPATEETVEDVTKPKSKKKKVVKKKTDDHDELIKKMLEQEIEKTELEKYEKIEFDVPKKLKPEFAALEPIKIERKEQKPTKVTILDATDVPKTVKLKPSKRKEKPAEELTVQLPKFRLKARMVLVEYPPAPLIPKTTDIGAIKDNGELSRNIEEAEEILKFKPHKTKKIKKIKDDLEKVELEKYEKYISSEEEPEEKTPYKKPEKAPKPEEKQEDVKLKLGKGKKKPKEEEAPENVTLKNIPQKPQEVEEEVELKQKPKEVEIVEEQTKKPKDGEFVVEPFEPSEFDRPEYVPDELEQIEHPEIPEKVKKPSKTKYKPKDKSKSEPETIVSEIVAGVPKEEEAIPEQDVKFRKPERDAPEETDSEIKLRPVPQASKDENPDEQALVTPKAEEPIPQEIEDKAIDDEKKPKKSKPKKVQPKEQEIAKEEPEEFEVSVKEEEALVDKPIEIEKPKDVKVKEKKPKEAPVSEVVVIEEEPKPEEVPEEIPVEYKITTTVLEPEDAPKEHQVKVIDFDERQETTEEVIEEKVVTRKKKPKPQQPEEFEVTLKEPKEEQIQPDVVSAEISLPIEEPEQKPEQYEVELKITQTTPEEPNDVQIAVKEKVKTKPVKKVKEDKIVVVEAEEEKQPVEETIVEVEKQEEKKKSEKPKSYEFKISETQSIEEKPIEVAEEAPEETPKVVEKKVAEKFDSYEFTLKETDEEKVITVDDQPEEEAPVEVVFKKKPKEPEAVEAEFVMTEPKIVEETSVETAIKQKKTKKPKKDEEEAQLAIKVVESEAPVAEEVFSEAPESKIVEEEVIAEEKPKEFTIRVSESEPKPEEPSVEQFTVKKRKPSVTFADEPATEIVIKESKPAEVVTEDAHIKTKKPKKKVTDVEAEELKIKITEEVPQEIPILEEVSEEEVITETKKTAPVVEEKTYKIGIKETEPEKPAEAIVEEEEPVVTEPIEEAPKPEVFEEHKVRVIEETPRELVEEVIEEEVKVIRRKKPKPEIKEEPEAEVTVSTPKPVEEVEATSSIAVIPEQPTEEEAADLKITIIEEETPPQELVQEIEEIEIVEEPKAPEEQPTDFTFATKDSEKKPTVEELPEEQVTIQKKKKKAPVPEVVEEPEAEFLVKPKTPVQEVTEEAKITKSKKPVKEEEAAAELKVTITEEIPTEPEVQEIIEEIEEIEEEKPAEYVIEVKESQPEAVEDKEVSLPKKKPKAPIVEEPEAEITLKPKVKSEEVQEEAKIVKKKPKKIDEVAVADELTVKVEEEVVPEPIVEEEVIEEFEIKKKPKEPEPEDIVDAAIVKLKKPEPVDADEVVAEVTLKPKAKTEVTEEEFSVDVKLPKEKKERPVEIEEEEIIEEAVVIRKKPKKPFEPTVEDLEETEFSLSFKKPHTINEGVEEAATVLKKRPVKPTTLDEAAAELSIKRQEEEYEEGEDIEEFVVSQQRKPKPLQITEEDEEAYTVKKLKRRKQVDIPEYADVENVTFRARSTKTKEDVDQEFNIALDSYAEEEISMSGKVKLKKPIKKTFSEAADEAKIKIIQDFDDGEEPIIEEIRDDEDTIDEVEEPEEYFVEELPPDEVDFKLKPKKHPKPAYSVQDEEEEQFLIGIRHPKRDSVTYDEDSLTFKKKRKVVQQLFNEDGASLNITREMNVEESENLNIMYSICNYIADNNEAINLVEGEKVTVVGRHSSEWWYVKKSTTEEEGWVPAQYLMEPEEYAQYVQNKLHEKIDKLPVFERPGPEDKPIAPRFIEKLQPIHTPDGYTVQFECKVEGNPRPQIAWFRETAIIKPSQDFQMFYDDDNVATLIIREVFPEDAGQFTVVAKNAAGFTSSTTELIVESPLSDHGSDATALSRRSMSRESSLADILEGIPPTFSKKPKAQYVDENTNVILECRLVAVPEPDIVWTFNGEDIDEEEIKNVRIVTESDMHMYCSVVHISKVKKSQEGTYEVIATNREGEARLPITLKVRTTDKEAPQILEPLRNMVIREGESVVLSTQIVGNPPPKVTWYKDGKPVKNAKSDKDLHTLTLITPQKSEKGEYTVKAVNPLGSVETTANLTIEEPAGGNAEPPLFVERFEEQNVPQKGEIRLPAKVSGNPVPEVQWLFNNTPLFPSERIQQVYDGENIELIIKDANPETDSGDYKCIASNPIGKTSHGARVIVEVDEVTFTKKLKKTITIEEVQSLTLECETSHVVTTKWFFNGKELSGMDHRVVVEDGKTHKLVIRNTNLRDSGTYTCKVKKQETQSTVEVLQRKPDFIKVLEDYEVTEKDTAILDVELTTEATEVTWYKDGEKITPENKNVEFIKDGKARRLVIRDVTIHDEGQYTCKIEGQECSCELVVIELPPEIVEPLNDVAVTKGENAVFEVELSKGDALVKWFKNGKEIVFNERIQLAIDGKKQSLRIVKAKPEDVGEYSVQVGEQTSKAKLTVEEPLVDFVIRLPDITLATKTTDAEFTVQLSQPDVEVTWCKKGKPIKPNQKHEVFVEGTVRRLVIHDASDEDAGEISCVAENVTSSTKLCVEELKLPPVITSDKDQTIKVKENDDVTFTVKYTGVPTPEACWTTRKVVIPKSKRTIPTIDEQSAKLTIKKVVDDDEGEYTVKLVNPVGEAEASLHLVIMRKPTAPGTPQPLEIMHDSITLYWKAPEDDGKSEIIEYILEYQDVKEEKWTEIRKIKDTTYTISKLKIDTEYVFRSIAVNEVGPSPPSPLSPPIRLVPKVETKAPSVQEPLQDVVSELDKEVTLSCVFGGIPEPKVTWKKNGQVFESRSIRYENRVAKYTIEKTTIETEATYTCVATNEKGSAETSCRLKLQQKPVLEVEDKYLTQKLRTGSILTIPATVRGYPQPTVTWHKETIEQKTTKSVTIETTETTSTYTVKKVTREQSGKYKVTATNESGTTYVECTVQVIDKPSRPQSLEIKDIKKDSIVLEWTPPVDDGGLDIEKYTLEKCDVQNNVWMKVSDFNKDIKSYAVQKLSMNAQYMFRVVAANPIGESEPTESDPVTITKKFEKPSPPRGPTTVSGMNDTSFNLAWEPSETDGGSKIIEYIVEIREETETTYRSVGVTLGTVTNIHVEKVVRNKGYFFRIYARNEVGTSEAFETTEKIVLGRKITPPSPPQNLRAPDVTSRSVTLDWEVPARNGGSEITGYCVEKRSSTSTNWTKVITLDAHQLHYTIDNLKEKCEYWFRVSAENEVGLGAPAVTESISLKTHASEFILVVRNCGSYTEFGFLKAVPSPPTGPLEARVLAANAHIFEWGLPESDGGAPLLGYHIAIRDMKKTMWIEVGRVPAGVLKFQIRDLQENHEYMIRIFAKNEIGLSEPLESEEPYKAMTAGHESLPDEPRTEMSSCNTSSWLRDHHMDADIHSYARGRLLQRDEYFFRLWAELPKSKKKKSSK

Gene
SLS
Protein
Secologanin synthase
Organism
Catharanthus roseus
Length
527 amino acids
Function
Component of the seco-iridoid and derivatives monoterpenoid indole alkaloids (MIAs, e.g. secologanin) biosynthesis pathway. Catalyzes the conversion of loganin into secologanin.
Similarity
Belongs to the cytochrome P450 family.
Mass
61.055 kDa
Sequence
MEMDMDIIRKAIAATIFALVMAWAWRVLDWAWFTPKRIEKRLRQQGFRGNPYRFLVGDVKESGKMHQEALSNPMEFDNDIVPRLMPHINHTIKTYGRNSFTWMGRIPRIHVMEPELIKEVLTHSSKYQKNFDVHNPLVKFLLTGVGSFEGAKWSKHRRIISPAFTLEKLKSMLPAFAICYHDMLTKWEKLAEKEGSHEVDIFPTFDVLTSDVISKVAFGSTYDEGGKIFRLLKELMDLTIDCMRDVYIPGWSYLPTKRNKRMKEINKEITDMLRFIINKRMKALKAGEPGEDDLLGVLLESNIQEIQKQGNRKDGGMTINDVIEECKLFYFAGQETTGVLLTWTTILLSKHPEWQERAREEVLQAFGKNKPEFERLNHLKYVSMILYEVLRLYPPVIDLTKIIHEDTKLGPYTIPAGTQVMLPTVMLHREKSIWGEDAMEFNPMRFADGVANATKNNVTYLPFSWGPRVCLGQNFALLQAKLGLAMILQRFKFDVAPSYVHAPFTILTVQPQFGSHVIYKKLERQNF