Protein
Folate-biopterin transporter
Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Function
Mediates folate monoglutamate transport involved in tetrahydrofolate biosynthesis. It also mediates transport of antifolates, such as methotrexate and aminopterin.
Similarity
Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.
Sequence
MLVAMSMTPIAILFSTPLKRFLREKVLLGNAPSWELLAILSIYFVQGVLGLSRLAVSFFLKDELGLSPAAMGALIGLGAAPWILKPVLGLMSDTVPLFGYRRRSYLWLSGLMGSAGWLLFAAWVSSGTQAGLVLLFTSLSVAIGDVIVDSLVVERAQRESLAQVGSLQSLTWGAAAVGGIITAYASGALLEWFSTRTVFAITAIFPLLTVGAAFLISEVSTAEEEEKPQPKAQIKLVWQAVRQKTILLPTLFIFFWQATPSAESAFFYFTTNELGFEPKFLGRVRLVTSVAGLIGVGLYQRFLKTLPFRVIMGWSTVISSLLGLTTLILITHANRAMGIDDHWFSLGDSIILTVTGQIAFMPVLVLAARLCPPGIEATLFALLMSVMNLAGVLSFEVGSLLTHWLGVTETQFDNLALLVIITNLSTLLPLPFLGLLPAGDPQVKDKTEKEDNPDDPGDRLVLPPAEVFEHHTVGSLSDQNFLPEFFPEKSSSRP