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slc5a8

Gene
slc5a8
Protein
Sodium-coupled monocarboxylate transporter 1
Organism
Xenopus laevis
Length
622 amino acids
Function
Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane (By similarity).
Similarity
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
Mass
67.556 kDa
Sequence
MVTPGNIGSFTVWDYLVFALMLLISAVIGIYYAFAGGGQKTSKDFLMGGRSMTAVPVALSLTASFMSAVTVLGTPAEVYRFGAMFIIFAFSYTIVVIISSEVFLPVFYRLGITSTYEYLELRFNKFVRLLGTILFIIQTVLYTGIVIYAPALALNQVTGFDLWGAVVATGVVCTFYCTMGGLKAVVWTDVFQVGIMVAGFTSVIIRAVVVQGGIGPILNDSYYGDRLNFWDFDPNPLKRHTFWTIVVGGTFTWTGIYGVNQAQVQRYIACKTRFQAKMSLYVNLIGLWAILACAVLSGLAMYSIYKDCDPWTAKFVSAPDQLMPYLALDILRDYPGLPGLFVSCAYSGTLSTVSSSINALAAVTVEDLIKPYIRSLSEKKMSWISKGTSLLYGAICIGMAGIASLMGGLLQAALSIFGMVGGPLLGLFSLGILFPFVNSLGAVIGLLSGFAISLWVGIGSQIYAPSPSSSLPKPLSLEGCNFTSIESNWTSTVMPMMTTLIPETQVSSRPELADSWYSLSYLYFSTIGTIVAVLVGVIVSLLSGGLKQNVNREFLLTSEDFSYLNVLFSPCKEKGQEEKVEVLNWKARRTDNDMEQGTDNPAFNNMEMTSTEKGEKTNGITA

Gene
slc5a8
Protein
Sodium-coupled monocarboxylate transporter 1
Organism
Xenopus tropicalis
Length
620 amino acids
Function
Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane (By similarity).
Similarity
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
Mass
67.371 kDa
Sequence
MVTPGNIGSFTVWDYVVFALMLLISAVIGIYYAFAGGGQKTSKDFLMGGRSMTAVPVALSLTASFMSAVTVLGTPAEVYRFGSMFSIFAFTYAIVVVISSEVFLPVFYRLGITSTYEYLELRFNKFVRLLGTILFIIQTVLYTGIVIYAPALALNQVTGFDLWGAVVATGVVCTFYCTMGGLKAVVWTDVFQVGIMVAGFSSVIIRAVVVQGGIGPILNDSYYGDRLNFWDFTPNPLQRHSFWTIVVGGTFTWTGIYGVNQSQVQRYIACKTRFQAKLSLYINLLGLWAILACAVLSGLAMYSIYKDCDPWTAQFVSAPDQLMPYLSLDILRDYPGLPGLFVSCAYSGTLSTVSSSINALAAVTVEDLIKPYFRSLSETKMSWISKGTSLIYGAICIAMAGLASLMGGLLQAALSIFGMVGGPLLGLFALGIIFPFVNSLGAVIGLLSGFAISLWVGIGSQIYPPTASSSLPKPLSLEGCNFTSFESNWTTTVMPMMTTLIPEVSSRPELADSWYSLSYLYFSTLGTIVAVVVGVIASLLSGGLKQNVNRDFLLTSQDFSYLNVLFSNCKKKGQEEKVEVLNWKMRSTDTDMDQGTDNPAFNHMEMSSTEKKEKMNGIIA

Gene
Slc5a8
Protein
Sodium-coupled monocarboxylate transporter 1
Organism
Mus musculus
Length
611 amino acids
Function
Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons.
Similarity
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
Mass
66.766 kDa
Sequence
MDASRDIGSFVVWDYVVFAGMLLISAAIGIYYAFAGGGQQTSKDFLMGGRSMSAVPVALSLTASFMSAVTVLGTPAEVYRFGAIFSIFVITYFFVVVISAEVFLPVFYRLGITSTYEYLELRFNRCIRLCGTILFIVQTILYTGIVIYAPALALNQVTGFDLWGAVVATGVVCTFYCTLGGLKAVVWTDVFQVGIMVAGFASVIIQASITQHGINKILSDAFNGGRLNFWNFDPNPLQRHTFWTIVIGGTFTWTTIYGVNQSQVQRYISCKSRLHAKLSLYVNLVGLWVILTCSIFCGLALYSRYRECDPWTSKKVSAIDQLMPYLVLDILKNYPGVPGLFVACAYSGTLSTVSSSINALAAVTVEDLIKPRFKSLSEKSLSWISQGMSVLYGALCIGMAALASLMGALLQAALSIFGMVGGPLLGLFSLGILVPFANSIGALTGLLAGFAISLWVGIGAQLYPPLPERTLPLPLETYGCNITHNGSDWMSTTEMPFSTSAFQIHNAERTPLMDNWYSLSYLYFSTIGTLTTLFVGILISLSTGGRKQNLDPRFLLTKQDFLSNFDVFKKRNHVLNYKLHPVEVGGTDNPAFNHVELNFTDHSGKINGTRL

Gene
slc5a8
Protein
Sodium-coupled monocarboxylate transporter 1
Organism
Danio rerio
Length
610 amino acids
Function
Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane.
Similarity
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
Mass
66.359 kDa
Sequence
MPGSGGPVATFSVWDYVVFAGLILVAAGIGLFQSFRGRKEASSDEFLLGGRQMTAVPVALSLTASFMSGITVIGTPAEAYLYGTPFWLFFISYAIMSTISAEIFVPLFYRLNITSTYEYLEMRYNKLIRVIGTSMYIIQTALYTGMVIFAPALALNQITGLDLWGVLVATGAVCIIYCTLGGLKAVIWTDVFQMIIMLGGFVAVIARGAVLQGGLGRVWNDSFYGGRLETFSFDPDPLRRHSFWTIVVGGSLMWASMYSINQSQVQRYISCRTMTHAKLSLYVNMVGLWVTVSLAMMSGLTMYSIYKDCDPFTNKDVGATDQLLPYLVMDILADFPGLPGLFVAAAYSGTLSTVSSSINALVAVTVEDFMKPAWPSLTERQLSWINMGMSVFYGAVCIGMAGVASMMGNILQAALSIFGMISGPLLGLYMLGMFFRCANSTGGLAGLASGLAITLWVGIGAQLYPPLPEKTLRLPLSVEGCVALNTSETTTMTPFSTVLQTTTPQPRPALADNWYSLSYLYFSPVGIVVTMIIALIVSAISGGCKQKKVRPELFISKSDLICFRCKKSDSEVSDLIETKPKDNQGLDSPVFYDNEIVLKEKDQQEKITKL

Gene
SLC5A8
Protein
Sodium-coupled monocarboxylate transporter 1
Organism
Homo sapiens
Length
610 amino acids
Function
Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons.
Similarity
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
Mass
66.578 kDa
Sequence
MDTPRGIGTFVVWDYVVFAGMLVISAAIGIYYAFAGGGQQTSKDFLMGGRRMTAVPVALSLTASFMSAVTVLGTPSEVYRFGAIFSIFAFTYFFVVVISAEVFLPVFYKLGITSTYEYLELRFNKCVRLCGTVLFIVQTILYTGIVIYAPALALNQVTGFDLWGAVVATGVVCTFYCTLGGLKAVIWTDVFQVGIMVAGFASVIIQAVVMQGGISTILNDAYDGGRLNFWNFNPNPLQRHTFWTIIIGGTFTWTSIYGVNQSQVQRYISCKSRFQAKLSLYINLVGLWAILTCSVFCGLALYSRYHDCDPWTAKKVSAPDQLMPYLVLDILQDYPGLPGLFVACAYSGTLSTVSSSINALAAVTVEDLIKPYFRSLSERSLSWISQGMSVVYGALCIGMAALASLMGALLQAALSVFGMVGGPLMGLFALGILVPFANSIGALVGLMAGFAISLWVGIGAQIYPPLPERTLPLHLDIQGCNSTYNETNLMTTTEMPFTTSVFQIYNVQRTPLMDNWYSLSYLYFSTVGTLVTLLVGILVSLSTGGRKQNLDPRYILTKEDFLSNFDIFKKKKHVLSYKSHPVEDGGTDNPAFNHIELNSDQSGKSNGTRL