Protein
Nonribosomal peptide synthase sidC
Organism
Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371)
Function
Nonribosomal peptide synthase; part of the siderophore biosynthetic pathway (PubMed:26960149). Arthroderma benhamiae produces 2 types of extracellular siderophores, ferrichrome C and ferricrocin (PubMed:26960149). The biosynthesis of these siderophores depends on the hydroxylation of ornithine to N(5)-hydroxyornithine, catalyzed by the monooxygenase sidA (PubMed:26960149). The structure of ferricrocin differs from ferrichrome C only by a serine for alanine substitution and the assembly of both siderophores is suggested to be performed by the nonribosomal peptide synthase (NRPS) sidC (PubMed:26960149).
Similarity
Belongs to the NRP synthase family.
Sequence
MDSFLCDRYTQFPSLNYGAEDVPSQASATWELDNVTDLNRLILAWASILSRLSEEESPVIQIDGAAARIHLESGRIESVQIEKSGNSGSRTAILTSDTPITSERCQLEIRYTPHQLHGSITSRGCTSVRYLDQLARNLESLLREPLPLSIVNPTPLILPGPRLFHEMVRHTGNEPAISFLNESGEVEDLSYEMLHSLSEQLASHLVHILASLPPPGQHGKIIPVLLPQSLDLYVAWLAILKAGAAVCPLNLDTPSERLNFIVGDVDARVVVTNEGLTSAFQNIETSITIVKMEEIKTFAPGCLSSVDVCNEDLAYVMYTSGSTGLPKGVGISHQAAVQALLAHDEIIPGFRRFLQFAAPTFDVSVFEIFFPLFRGVTLVGCNRRLMLNDLPGIINQLNIDAAELTPTVCGELLQSRDAVPCLKLLLTIGEMLTRHVVDEFGSSKDRPGLLHGMYGPTEATIHCTAVSSVRAGSLVGNIGTPFKTVSAFIISMDHIVGQEPVILPVGHVGELVVGGPQLARYYLNRPTENRNAFIDSKTYGRLYRTGDKARLHPNGELQCMGRISTGQVKLRGQRIELGEIENVLLKNQYVRNVAACVIQGALVAFLSADVAHCTSRDLQLTCRRSLPKFMIPGNFVILNKLPRLPSGKIDRKGLEAEYILSKGVDQTDLAEPAGDIEQKISVSLNLLLESSLTPTASLASAGLDSLRAIHLASSLRKEGVFLNALDILEADSIRKMAALVLKSQPEVTVIPTESEPLKMWNTIIQQGHEMLKLTENLQQPTDIIPCSPIQTGMLLETKLNPKAYFNSVELQFDRGISLEDVKSAFLSTALQNEVLRSGFIEIDFPGFPYAQVVWESLHPDQIIESKIFDHNLELQNQWDILHPLRVQLCVIDGQPKALVHIHHSLYDGWSWDQIMRDLVSALENKQLTQRPQYRLFTLFHINNHSSEIREQALNYWRSHLQGSTPCLWPNFQDRSDLPKVTQVVERQFNVDIDQLDSFVRDFRISRQTIFQAAIGYLLSAYNGTSDIILGNVSAGRTLPIDGIESIVGPCISTLPLRLNLQKARTVRDLLAILHGLNRKSLVHGFVPLRDVKQVSGINTADQLFDTLFVWQDNFTTVCGPIAQVTSRDFLEFTLTTELGIQDGKIWAKATFEESILPESHVVIFLKQIESIAMTFLESADRLLEDIPFHLPESLLSMENNFPPPLKSVPGLSDSVEELAKTDSERIAVEFLDSLDPETGDRAIKTLTYSELDAQSNKLAGQLRNLGVVEGNLVAICLEKSLELYISILAVIKAGAGYVPITPQTPIMRMKHIIQQASCRICIADSEIQAELSDVPNTTAMLAKPQILVENALYEFPKAPGSCPAYAVFTSGTTGTPKGVLISRFNLESNIAVLSALYPDFPESRLLQACSHAFDVSVFEIFFAWSRGMTLCSAKNDVLFRDIELAIRKMRITHLSMTPTVAALVRANNVPLVKFLVTAGEALTPKVRMDWAGKGLWQGYGPSETTNICTVKPNICMSHFISNIGRPLPNTSVFVLAEGERFSLVPRGAVGELCFGGDQVGIGYLNMEDLTRQKFLIHEAYGRIYKSGDYGRLLPDGSIAFVGRRDDLVKIRGQRIELGEITSVLMTHENVKDCATIVCDSNNGDSGDSKQLISFWVPDNINIDGLGQHENSHIFQQLFDYIGDHLPSYMIPSFLIPISHIPMTTIGRKIDKEALKYMYLSANPTLLDVYSRGKEEEHTQENLTDNEAKVAGLVAQVTGVSTKEIGRHTSFYRLGFDSVIAIALSRELKLAGFGQIDISVIMKNDSIARLTRKISQSIEAQMPSLESIPTFDHLFSRELIRKIKDEASSHGVNVTKILPCTSLQEGMLSGISTGNDASYYNHLVFEINRNIELLKTAWMKMVARHDILRTWFRQTDDARFPFVQVVLERLDIAWQSIECPIADAPSTLEKSKLAVAVKEGPHSLYSFTVLQCVDSPKVFLLLSIHHALYDGEAMEVLLQEVQECLLEHQLPPVVPFDLYLHEMIKVNSDSTDQFWSNYLKDFTPTLFTSPSSLVKGSPKMSRSTSHIPSSSFTEVCNACKSSSVTTLSLLQAAWSRLICLLSGSPDICFGDVVNCRSIPIDGAQRIVGPCFNTLPVRTSLNGNMTNIDLMRNLQSNRAATLPYQLSSMRRIQSRFSQRGQRIFDSLLLLQGRPLQLNESLWRMVSENGVMDFPIIFEIIPHPESDSLQFIFHFDEGLVPTTDIDTITACYHAILNHTLRFPEARVMDFSLVESDGQVSGGLSVFRKLGEANGDHKSNGYGKSEEWSAESLEIRNLLSAMSKIDKKRINMDTTIFELGLDSINAIQIAGHFRKVGYEISAADILEGPSIREIASVLQGSKSSPCVGLALHNFDFDSFQSLHLPSICDKLGLLESSVEAIRPCTTPQAGMLASFINSEGLLYFNSFTLKSPTPLNLIALRFVWESVMERNEMLRTGFCEVKDDIFPFAMVTYRPGIIELPWNECLSPSKRMSDARHEQHLNGKSILNQLHRPPWFLTVKPCSDSTLMQLSAHHALYDAHSMNLILSEVINVYNGSTLPPAIPVSSVLGFIVEKFQSPESESYWSEVGPSFSATKFPDMNPLHAKVNDTRFLSRDCSFTMEKLQKGCRELGVTLQAVGQAAWSRILSSYVGESNVTYGLVLSGRDISEQAQDTAFPCLTTVPAHQNVEATNRELLQQIMKSNAMAVKYQFTSLTKIQRLSKADSPLFDTLFVFQKLASTDKQQPLWDVVEESSQTEYSVSLELIPSSDTLKLALTYQNHILPDGQASLLLDELDWLLTHILQYPDSTSSSLDTASRSIVSVLPRKDSKIDCPTQLLHEFVEVGATRHPSRVALEFAERINGKLITQSWTYKDLDEQGNRYANLLHHLGVKQGTLVGVSFQKCPEAYFSILGVLKVGCAFLAIDPSAPIARKQFILDDSKADILMCGMEQQDELKSLTGIRLVPVNEEGLLDGVNSTPPTLSFPLHGDATCYCLYTSGSTGTPKGCEITHDNAVQAMLSFQRLFGGHWDESSRWFQFASFHFDVSVLEQYWTWSVGICLTSCPRDTLFEDFAGTLRDLSITHIDLTPSLAQLIQPEDVPSLCRGVFITGGEKLKQEILEQWGPHEVIYNGYGPTEVTIGCTMLPRVTSSDKPTNIGPQFDNVSGYVFKQGTNTPVLRGGIGELCVSGPLVGKGYLNRPQLTAEKFQYIETYGERVYRTGDLVRMMHDESFCFLGRIDDQVKLRGQRLEINEINHVIKNSTEEVGDVVTMVLKHPTATKEQIVSFTTVVTSASTAACPEVDFSPEAGRVLEAIRSECRSHLPGYMIPTHIIPLTRFPLSSNNKIDNGQLRGIFASMLLSEMQALSSHEQESPTEDTDTIRKIIPILSRFTKVEEKTISSSSNIFELGLDSILVISFSRALREAGCPAAHPSVVMKCSTLSLLAKAVESPDNNVEGERRQYEDAKQKIAAFAHMHMSHLANELEVAPQDIEAITPCTSLQDGMLYQCLRNESHPYLTSFTFQLAPHTDIPMLKEAWKRAQVSFQLLRTKFPLTDDGYALVVLKEAALPWFEFAISKDDELESTAESYFKEWNLGFNNFMGRVWEIGIISSPKRRWMCLNIFHGLYDGISLPIILDAVKHVYNGGQMPRSMPFTEVLPLGPLRTVPAAKSFWAKHLENLSQTTIPRRSLPEPGSRTSTIRIEGFHCIEETRRSLNVTEKAMFHACWVYTFERYFNYIPTMGIVVSGRSFDSEDADVAVGPLFNTIPCNIPKFSFSTFSELIQACHDYSVSALPFQHTPLRSIMKWIGRSSQRPLFDVLFVFQKQENITSQSGESLWEPVASFTEADYPLALEVQSQGSGSFQVTAACQGDILTSDGISDLLEQFRLSLRSLVEEPFSNLSFSGNSTSLEASSKQIANKVIGGPSPNVTTSFQWSQAASLLRQEIAKLANLDVSEINEDSSVLEVGLDSIDAIKLSSRLKRDHIDLSVGNIMRNRTIRTMMAEVTVNGSATKADLTYLKSLESQLRRSLEEDGKDLGDIEHIYPATPLQEGMINEMLSSDGLHYFNHDILQISEDVDVTMLKNAWETIAKRHPILRTSFATVSDPNLPFSYAQLIHKSSIKIDWDIVDIAENSIESILQEERARALSLVMSKPLFNLRLIRDGAKLLLILSLPHAMYDGWSLTLLHQDVASAYSGQFSARPSYQHVLEDIISSSRDEGLQFWKGVLSDAEPSIFPPQPGAGDQGALVHRDETASDIPLSHVLNFCKAHGVTAQALGLTCWTIVLASYLGQLDVLFGTVMLGRDTEEASKVAFPTMNTVAVRGILHGSVSEMLEYVQRNLGNMLAHQHYPLRKIKSMMGVGNKDLFDTLFIYQKSPSSQEGQDKPLYKSINSSSSVEYSICVELEAIDDSAVWRVACKDTILGKKDTSQLVLQLLQVFKTIIQSPEIPTAGFVEVRERPTLDSVTQNGGSLPDGPGGIAIEPVVWSLLEERIRDTLSLVAAVPKEEITRNTTIFHFGIDSISAIKVSSLLRRQSVLISVRDILRAETVGKMAEIVNSAREKKPTTATSREKLLSLQTLKNSNIDLQLRKYGMKREDVEVFLPATAGQVYMLETWKNSHGKLFFPDFFYRVTGRITQSQLDNAWKVMTAKLPILRTTILSIGDTGMPYVLAELKQVSNPIIWRSDLRVKSNRRHVAARQGSGLVYLYASQTETETLLMLHIHHALYDAVALQHLINILESLFQDVSTPVNTPVDIAEFIQYGKAMSSEAQQEAFWKGYLGNDITPVAKKGSGPVMDVQAGAGKYQPGLLDNTDWLNKICQAEGLSVQAVFLAAYSKVHVREFHVRGADLTVGVYLANRSHDLVGLPELVAPTLNIVPLRIQDPGSRSVFELARIIQSDLHEIGSAENCTVSLAQIAEWTGIRLDTTVNFIKLPEVAAQVSTATSGAPQLVQVTEEEVLEWLSKESCNSNGSEQVDAAAKGSSSKLWLEEMLGIESGVGLENAGDVYKVSPPGSQLSQDSPEKQEANNKPSPQPSVDIEAAVRNNTLDVGVFGPSSDKALGVLDGVRRELLALQTSSAR