Protein
Tyrosine-protein kinase sid-3
Organism
Caenorhabditis elegans
Function
Tyrosine-protein kinase which plays a role in RNA-mediated gene silencing by mediating import of double-stranded RNA (dsRNA) into cells. Not required for import of ingested dsRNA into intestinal cells but involved in subsequent export from intestinal cells to internal tissues.
Similarity
Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily.
Sequence
MASTSGALVDDNVLEVLRKAQLDAFISQFVFLFNVRRFDHFSHVRDKDMLEIGMQQVQIRQLREQILKMSREMWNRSDPKQVYIQADQSMPAQNSIDEKALIPNEQIKLYELIGEGSFAVVKRGTWTQSNGTHVNVAVKILRDISPNIMDDLRVEASHLLKLQHPSLIRLYGIVRQPAMMVFELCEGGSLLDRLRDDKKAILLVSRLHDYCMQIAKALQFLESKHCVHRDVAARNILLARDERTVKICDFGLMRALKENEQMYTMAPQKKVPFAWCPPEALRHRKFSHASDVWSYGVTIWEVFTFGEEPWVGCRAIDVLKNIDAGERLEKPKYCSERIYQIMKNCWKFNPAERCKFGAIREDLVAAMFLDAVARETYNSIQPGALQLTKGDEVVVVENTGQDWFGQNKKNQKFGTFPRSVVFAQTNNAVAAATAVTPQKVPTAPTIRIPPSHPPPAPLKPLNNNTKTSLNDRTSKISMPVAGSFIHTGHGDPLGGQSWGNPATIADMYLKNPVNGAPLSSMSSGAEIIASKELLTNGGRSTHQPAAPSPAVMSKIRGLSLDLPEYDDFDRAFDDGFSPSKIELPREFCGNDSVISGGSNSIGLANTYVMEPPKQAFDIRGNRVLPPTNKAPVLIPTNPAPSVISSTASAGITLSTNSSQMFTSQDRHSNMPANLFPELQHRLNQGSSTGNGVRPRPASSIGIQNNDLSMLNPQVNRPFSVVNVPIVQQPANIPCLVPTPAPPAPAHFSQPVSSQRVAQQQQNTLQKALNDELKGNLNKRPTGTTAPPSNGFNAPRADVAPVQQRPISSASIPALQPQPIQHIQKPIQPQQVRIPPSTAPVQKPVQVSAPTHSNVAPTTSSQASADARNPLPPKTSPPVSNTPITVAPVHAAPTTSAPSTSVVTRRPTSTTAQMSDEERRSRIAMDISSALPAPSALLYGSNSTSSLPSAAVSTASSVPSTARDNPVETRPSQPHVTMPPKKSSEPILSSEVLQPTRLPSATTSQAKPVTQPIRHPSPPVATVIPTAVVDKKPVSQNQGSNVPLFNITNSSNGYPQLNGYPNYGNGFQAYGYGMNYHQGYPGYQGYNSYGNGMGQLALTHNAVTSLPPLVPSENRFSGTAQPLGESDIMEFLGTQQRQAGSSSRAVPPASASTSAASGITDLSMADKMEVLYREADFTHKGNCDTMVSQCNGNTEQALKLLKQQHLVDMELAMSTETARQALEARQYDLPAAANMLLG