shkC

Dual specificity protein kinase shkC

506 amino acids

Required for proper chemotaxis and phagocytosis; proper spatiotemporal control of F-actin levels in chemotaxing cells. Negative regulator of the PI3K (phosphatidylinositol 3 kinase) pathway. Predominantly phosphorylates serines and threonines and tyrosines at a lower level (By similarity).

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. SH2 domain-containing protein kinase subfamily.

57.135 kDa

MDSGLGSSYPEERSGPPEIRPEEINFEELIGTGSFGKVYKGRCRQKAVAVKLLHKQNFDAATLSAFRKEVHLMSKIYHPNICLFMGACTIPGRCVIVTELVPKGNLETLLHDQKIQLPLYLRMRMARDAALGINWLHESNPVFVHRDIKSSNLLVDENMRVKICDFGLSALKQKHKMLKDQSSAKGTPLYMAPEVMMFKEFNESSDVYSFGIVLWEILTRKEPFSHHRELEKFREAVCVKHERPPIPNDCLDSLRRLIEKCWDKEPISRPSFKEIISALDHVIIDAAISDLNGRDFWKKSFLTEQEVPWEAFIDALCNWSKAPARNQCDKTSIDYLNIKCLKAVLAESPKSEGTGVETVVNIEKFGKILEFFGPVPEPAPGHSIMDTVREILSQKWFHGDLDTTEAASRLNGQPIGSFLIRFSSTNAGCFTISQVVDGGSIKHQRVSRQGVKFNYQNVIYNSLIEIVSKNGGGANGDVKLDSQLGVPNYKFMSLFCVLNKESEVYQ