sh3bp4a

SH3 domain-binding protein 4-A

965 amino acids

Possible role in regulating endocytosis of the transferrin receptor at the plasma membrane. Alternatively, may function as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy (By similarity).

108.453 kDa

MAAHRIRVTNNNNVLPRCKSEGTLIDIDEGVTEASLVDVKVPSPSALRLAPSTSFGTAREVVAIKDYCPSSFTTLKFSKGDHLYVLDTSGGEWWYAHNNREMGYIPSTYVQPINYRNSSLSDSGMIDNLGDCSEEGAKELDLLGEWTGVCLKPSLPYDNNNPFSMLSSTNPFLNGSMDDVLDQNSNEKPNQCNSMDLLFFDLPSAPISTTSNTKGYSISGFDGTSTSADLEALQMLRKDNPFFRSKRSYSLSELSTLQAQSNPPLPSSGFFTGLKAPSPEQFQNREDFRTAWLNHRKLARSCHDLESLGQNPGWGQTQPVETNIVCKLDSCGGAVQLPDTNISIHVPEGHVAVGDTQQISMKALLDPPLELNNDRCSTVSPVVEIKLSNMEIKSFITLEMKVSVMTRTESPMAEIVCVRSDCKEGPYSPVPQAYIYGDTIQVQLDNLEPCMYVAVVVQAKHVSFSSNVWNHMVKKVTLGLYGPKHIHPSFKTVVAIFGHDCAPKTLLVSEVGKQAKSAPPVSLQLWGKHQFVLSRPQDLQIGMYSNMSNYEVKANDQARVVRGFQIKLGKVSRLIYMISSRKADEISDFTLRVQVKDDQDCILAQFCVQTPQPPPKTGMRNNGQRRFLKKKEVDKIILSPLAITTKYPQFQERCITNLKFGKLIKTVIRQTKNQYLLEYKKGDIIALLSEEKIKLKGQLWTKEWYIGYYQGKIGLVHVKNVLVLGKVKPIYFCGPDLTTTMLMEQILKPCKFLTYIYASVRTILMENLGNWRAFADALSYVNLPLTYFCRAELDSEPERVASVLEKLKEDCLNMETKEKKSFQKELMMALLKMDCQGLVARLIMDFVLLTTAVEVAPRWRDLAEKLAHVSKQQMEAYEAPHRDKTGMVDSEAMWKPAYDFLLTWAAQIGDSYRDVIHELHMGLDRMKNPITKRWKHLTGTLILVNCLDLLRSSAFSPAPQDDFAI